Cerebral Aneurysms and Variations in the Circle of Willis

In order to obtain information about the relationship between variations in the circle of Willis and aneurysms, 44 complete circles of Willis with aneurysm were studied macroscopically. The incidence of variations was significantly higher in the aneurysm series than in the control circles without aneurysm. There was a definite correlation between asymmetric proximal segments of the anterior cerebral artery and aneurysms of the anterior communicating artery, and a tendency to correlation was found in the case of asymmetric posterior communicating arteries and aneurysms on the internal carotid artery-posterior communicating artery junction. In the light of these findings it seems likely that through hemodynamic changes variation in the circle of Willis plays some role in the development of cerebral aneurysms. Stroke Vol 15, No 5, 1984

[1]  T. Fukushima,et al.  The horseshoe vortex: a secondary flow generated in arteries with stenosis, bifurcation, and branchings. , 1982, Biorheology.

[2]  L N Sekhar,et al.  Origin, growth, and rupture of saccular aneurysms: a review. , 1981, Neurosurgery.

[3]  H Handa,et al.  Experimentally induced cerebral aneurysms in rats: Part V. Relation of hemodynamics in the circle of Willis to formation of aneurysms. , 1980, Surgical neurology.

[4]  H. Handa,et al.  Anatomical variations of the arterial system of the base of the brain. , 1977, Nihon geka hokan. Archiv fur japanische Chirurgie.

[5]  H. Handa,et al.  [Variation of the circle of Willis related to the pathogenesis of cerebral aneurysm (author's transl)]. , 1976, Neurologia medico-chirurgica.

[6]  U. Slager,et al.  PATHOLOGY OF THE CEREBRAL BLOOD VESSELS. , 1974 .

[7]  G. Ferguson.  Physical factors in the initiation, growth, and rupture of human intracranial saccular aneurysms. , 1972, Journal of neurosurgery.

[8]  R. G. Berry,et al.  Circle of Willis in cerebral vascular disorders. The anatomical structure. , 1963, Archives of neurology.

[9]  W. Stehbens.  ANEURYSMS AND ANATOMICAL VARIATION OF CEREBRAL ARTERIES. , 1963, Archives of pathology.

[10]  H. Riggs,et al.  Variation in form of circle of Willis. The relation of the variations to collateral circulation: anatomic analysis. , 1963, Archives of neurology.

[11]  R. G. Berry,et al.  Anatomical studies of the circle of Willis in normal brain. , 1959, A.M.A. archives of neurology and psychiatry.