Influence of oryzanol on platelet aggregation in rats.

Platelet aggregation was measured using platelet rich plasma prepared from rats fed oryzanol in the control diet and those fed oryzanol in a 1 per cent cholesterol diet (HCD). Oryzanol with the control diet did not alter platelet aggregation induced by ADP and collagen. On the other hand, oryzanol fed along with HCD significantly inhibited platelet aggregation induced by ADP and totally inhibited aggregation induced by collagen.

[1]  T. Tabata,et al.  Effects of gamma-oryzanol and cycloartenol ferulic acid ester on cholesterol diet induced hyperlipidemia in rats. , 1987, Japanese journal of pharmacology.

[2]  L. Machlin,et al.  Influence of Vitamin E on Platelet Aggregation and Thrombocythemia in the Rat , 1975, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[3]  G. S. Seetharamaiah,et al.  Hypocholesterolemic activity of oryzanol in rats , 1988 .

[4]  R D Sharma,et al.  Hypocholesterolemic activity of unsaponifiable matter of rice bran oil. , 1987, The Indian journal of medical research.

[5]  D. Cornwell,et al.  Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase. , 1977, Prostaglandins.

[6]  G. FitzGerald,et al.  In vivo indexes of platelet and vascular function during fish-oil administration in patients with atherosclerosis. , 1986, The New England journal of medicine.

[7]  J. Suzuki,et al.  Comparative effects of two forms of gamma-oryzanol in different sterol compositions on hyperlipidemia induced by cholesterol diet in rats. , 1987, Japanese journal of pharmacology.

[8]  M. Ishihara,et al.  [Clinical effect of gamma-oryzanol on climacteric disturbance -on serum lipid peroxides (author's transl)]. , 1982, Nihon Sanka Fujinka Gakkai zasshi.

[9]  Haruo Nakamura,et al.  Effect of γ-oryzanol on Hepatic Cholesterol Biosynthesis and Fecal Excretion of Cholesterol Metablites , 1966 .

[10]  C. Rukmini,et al.  Studies on hypolipidemic effects of dietary rice bran oil in human subjects , 1989 .

[11]  M. Shinomiya,et al.  Effects of gamma-oryzanol on lipid metabolism in rats fed high-cholesterol diet. , 1983, The Tohoku journal of experimental medicine.

[12]  J. White.  Platelets in perspective. , 1981, The Western journal of medicine.

[13]  R. Colman,et al.  Platelet function in hyperlipoproteinemia. , 1974, The New England journal of medicine.

[14]  J. V. Prabhakar,et al.  Oryzanol content of Indian rice bran oil and its extraction from soap stock , 1986 .

[15]  A. B. Hanley,et al.  The genus Allium--Part 3. , 1985, Critical reviews in food science and nutrition.

[16]  R. Gryglewski,et al.  Prostaglandins, platelets, and atherosclerosis. , 1980, CRC critical reviews in biochemistry.