An insight on medicinal attributes of 1,2,4-triazoles

[1]  F. Supek,et al.  Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis , 2020, Tropical medicine and infectious disease.

[2]  Jie Liang,et al.  Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury. , 2020, European journal of medicinal chemistry.

[3]  N. Zaher,et al.  Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors. , 2020, Acta pharmaceutica.

[4]  Shakir Ali,et al.  Synthesis, characterization and anti-inflammatory activity evaluation of 1,2,4-triazole and its derivatives as a potential scaffold for the synthesis of drugs against prostaglandin-endoperoxide synthase , 2020, Journal of biomolecular structure & dynamics.

[5]  C. Supuran,et al.  1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy , 2020, Journal of enzyme inhibition and medicinal chemistry.

[6]  N. Boechat,et al.  The Development of Novel Compounds Against Malaria: Quinolines, Triazolpyridines, Pyrazolopyridines and Pyrazolopyrimidines , 2019, Molecules.

[7]  Haibo Yu,et al.  Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity. , 2019, European journal of medicinal chemistry.

[8]  R. I. Benhamou,et al.  Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles. , 2019, European journal of medicinal chemistry.

[9]  C. Supuran,et al.  An efficient method for the synthesis of novel derivatives 4-{5-[4-(4-amino-5-mercapto-4H-[1,2,4]triazol-3-yl)-phenyl]-3-trifluoromethyl-pyrazol-1-yl}-benzenesulfonamide and their anti-inflammatory potential. , 2019, Bioorganic chemistry.

[10]  Jun Shi,et al.  Synthesis, Crystal Structure, and Agricultural Antimicrobial Evaluation of Novel Quinazoline Thioether Derivatives Incorporating the 1,2,4-Triazolo[4,3-a]pyridine Moiety. , 2019, Journal of agricultural and food chemistry.

[11]  M. Elsohly,et al.  Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors , 2019, Archiv der Pharmazie.

[12]  M. Kariduraganavar,et al.  Click chemistry based regioselective one‐pot synthesis of coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4H)‐ones as newer potent antitubercular agents , 2019, Archiv der Pharmazie.

[13]  P. Pávek,et al.  Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2'-Oxidase. , 2019, Journal of medicinal chemistry.

[14]  Amr A. Kamel,et al.  Design and synthesis of 1,2,4‐triazolo[1,5‐a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity , 2019, Archiv der Pharmazie.

[15]  C. Freire-de-Lima,et al.  Design, Synthesis, Trypanocidal Activity, and Studies on Human Albumin Interaction of Novel S-Alkyl-1,2,4-triazoles , 2019, Journal of the Brazilian Chemical Society.

[16]  Wen-long Huang,et al.  Design, synthesis and biological evaluation of novel 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as potential BRD4 inhibitors. , 2019, Bioorganic & medicinal chemistry.

[17]  D. Sriram,et al.  Ultrasonication-ionic liquid synergy for the synthesis of new potent anti-tuberculosis 1,2,4-triazol-1-yl-pyrazole based spirooxindolopyrrolizidines. , 2019, Bioorganic & medicinal chemistry letters.

[18]  A. Mittal,et al.  Design, synthesis and photoinduced DNA cleavage studies of [1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones. , 2019, Bioorganic chemistry.

[19]  P. Gong,et al.  Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine derivatives as potent antitumor agents , 2019, New Journal of Chemistry.

[20]  R. Al-Salahi,et al.  Synthesis and biological evaluation of 4-(1H-1,2,4-triazol-1-yl)benzoic acid hybrids as anticancer agents , 2019, RSC advances.

[21]  F. Badria,et al.  Synthesis, Biological Evaluation and In Silico Studies of 1,2,4‐Triazole and 1,3,4‐Thiadiazole Derivatives as Antiherpetic Agents , 2019, ChemistrySelect.

[22]  K. Yelekçi,et al.  Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4‐triazole containing hydrazide–hydrazones derived from (S)‐naproxen , 2019, Archiv der Pharmazie.

[23]  Mamta,et al.  Synthesis and bioevaluation of 6-chloropyridazin-3-yl hydrazones and 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines as cytotoxic agents. , 2019, Bioorganic chemistry.

[24]  O. Rabal,et al.  Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors. , 2019, European journal of medicinal chemistry.

[25]  Mohamed M. Abdulla,et al.  Efficient Synthesis of Some New 1,3,4‐Thiadiazoles and 1,2,4‐Triazoles Linked to Pyrazolylcoumarin Ring System as Potent 5α‐Reductase Inhibitors , 2019, Journal of Heterocyclic Chemistry.

[26]  Hong-min Liu,et al.  Synthesis, structure-activity relationship studies and biological characterization of new [1,2,4]triazolo[1,5-a]pyrimidine-based LSD1/KDM1A inhibitors. , 2019, European journal of medicinal chemistry.

[27]  M. Bajda,et al.  Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs. , 2019, Bioorganic chemistry.

[28]  S. Arumugam,et al.  Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies. , 2019, Bioorganic chemistry.

[29]  Weiqi Wang,et al.  Triazole derivatives and their antiplasmodial and antimalarial activities. , 2019, European journal of medicinal chemistry.

[30]  Wei Li,et al.  Design, synthesis and biological evaluation of novel 7-amino-[1,2,4]triazolo[4,3-f]pteridinone, and 7-aminotetrazolo[1,5-f]pteridinone derivative as potent antitumor agents. , 2019, European journal of medicinal chemistry.

[31]  E. De Clercq,et al.  Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs. , 2019, Bioorganic & medicinal chemistry.

[32]  Tamer M. Ibrahim,et al.  Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1,2,4-triazoles , 2019, Medicinal Chemistry Research.

[33]  Pei-liang Zhao,et al.  Discovery and optimization of 3,4,5-trimethoxyphenyl substituted triazolylthioacetamides as potent tubulin polymerization inhibitors. , 2019, Bioorganic & medicinal chemistry letters.

[34]  F. Omar,et al.  Synthesis, antimicrobial activity and molecular modeling study of 3-(5-amino-(2H)-1,2,4-triazol-3-yl]-naphthyridinones as potential DNA-gyrase inhibitors. , 2018, Bioorganic chemistry.

[35]  S. Tariq,et al.  1,2,4-Triazole-based benzothiazole/benzoxazole derivatives: Design, synthesis, p38α MAP kinase inhibition, anti-inflammatory activity and molecular docking studies. , 2018, Bioorganic chemistry.

[36]  A. Brancale,et al.  1 3-Aryl / Heteroaryl-5-Amino-1-( 3 ’ , 4 ’ , 5 ’-Trimethoxybenzoyl )-1 , 2 , 4-Triazoles as Antimicrotubule Agents . Design , Synthesis , Antiproliferative Activity and Inhibition of Tubulin Polymerization , 2018 .

[37]  Y. Asiri,et al.  Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking. , 2018, European journal of medicinal chemistry.

[38]  Sha Zhou,et al.  Design, synthesis, biological activities and DFT calculation of novel 1,2,4-triazole Schiff base derivatives. , 2018, Bioorganic chemistry.

[39]  A. Bender,et al.  Discovery of a non-toxic [1,2,4]triazolo[1,5-a]pyrimidin-7-one (WS-10) that modulates ABCB1-mediated multidrug resistance (MDR). , 2018, Bioorganic & medicinal chemistry.

[40]  J. Adrio,et al.  Antifungals , 2018, Reactions Weekly.

[41]  Chun-ling Xiao,et al.  IMB-SD62, a triazolothiadiazoles derivative with promising action against tuberculosis. , 2018, Tuberculosis.

[42]  Manish P. Patel,et al.  Microwave assisted one-pot synthetic route to imidazo[1,2-a]pyrimidine derivatives of imidazo/triazole clubbed pyrazole and their pharmacological screening , 2018 .

[43]  H. Badwaik,et al.  Analgesic and Anti-inflammatory Potential of Merged Pharmacophore Containing 1,2,4-triazoles and Substituted Benzyl Groups via Thio Linkage , 2018, Journal of Heterocyclic Chemistry.

[44]  W. de Souza,et al.  In vitro antileishmanial activity of ravuconazole, a triazole antifungal drug, as a potential treatment for leishmaniasis , 2018, The Journal of antimicrobial chemotherapy.

[45]  Y. Zhang,et al.  Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi. , 2018, European journal of medicinal chemistry.

[46]  N. El-Deeb,et al.  Design, synthesis, molecular modeling and anti-proliferative evaluation of novel quinoxaline derivatives as potential DNA intercalators and topoisomerase II inhibitors. , 2018, European journal of medicinal chemistry.

[47]  C. Godugu,et al.  Synthesis of 1,2,4-triazole-linked urea/thiourea conjugates as cytotoxic and apoptosis inducing agents. , 2018, Bioorganic & medicinal chemistry letters.

[48]  S. Joshi,et al.  Microwave‐Expedited Green Synthesis, Photophysical, Computational Studies of Coumarin‐3‐yl‐thiazol‐3‐yl‐1,2,4‐triazolin‐3‐ones and Their Anticancer Activity , 2018 .

[49]  Min Liu,et al.  Coumarin–triazole Hybrids and Their Biological Activities , 2018 .

[50]  S. Tariq,et al.  Synthesis, p38α MAP kinase inhibition, anti‐inflammatory activity, and molecular docking studies of 1,2,4‐triazole‐based benzothiazole‐2‐amines , 2018, Archiv der Pharmazie.

[51]  Heba A. Hassan,et al.  Design, synthesis, anticonvulsant activity, and pharmacophore study of new 1,5-diaryl-1H-1,2,4-triazole-3-carboxamide derivatives , 2018, Medicinal Chemistry Research.

[52]  Y. Zhang,et al.  Potential Antimicrobial Isopropanol-Conjugated Carbazole Azoles as Dual Targeting Inhibitors of Enterococcus faecalis. , 2018, ACS medicinal chemistry letters.

[53]  S. N. Bukhari,et al.  Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies. , 2018, Bioorganic chemistry.

[54]  L. Yurttaş,et al.  The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species. , 2018, European journal of medicinal chemistry.

[55]  Hany E. A. Ahmed,et al.  Design, Synthesis and Cytotoxic Evaluation of Novel Chalcone Derivatives Bearing Triazolo[4,3-a]-quinoxaline Moieties as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects , 2017, Molecules.

[56]  Heba A. Hassan,et al.  Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations. , 2017, Bioorganic chemistry.

[57]  A. Gamal-Eldeen,et al.  Synthesis, antiproliferative, anti-tubulin activity, and docking study of new 1,2,4-triazoles as potential combretastatin analogues. , 2017, European journal of medicinal chemistry.

[58]  H. S. Rosenzweig,et al.  The antitubercular activity of various nitro(triazole/imidazole)-based compounds. , 2017, Bioorganic & medicinal chemistry.

[59]  À. Muñoz-Castro,et al.  Coordination Polymers Containing 1,3-Phenylenebis-((1H-1,2,4-triazol-1-yl)methanone) Ligand: Synthesis and ε-Caprolactone Polymerization Behavior , 2017, Molecules.

[60]  Wenda Wang,et al.  Asymmetric synthesis of novel triazole derivatives and their in vitro antiviral activity and mechanism of action. , 2017, European journal of medicinal chemistry.

[61]  H. S. Rosenzweig,et al.  The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines. , 2017, European journal of medicinal chemistry.

[62]  Nevin Süleymanoğlu,et al.  Antileishmanial activity study and theoretical calculations for 4-amino-1,2,4-triazole derivatives , 2017 .

[63]  Xuefeng Wang,et al.  Synthesis and biological evaluation of disulfides bearing 1,2,4-triazole moiety as antiproliferative agents , 2017, Medicinal Chemistry Research.

[64]  B. Jayaram,et al.  Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents. , 2017, European journal of medicinal chemistry.

[65]  J. Sangshetti,et al.  Antileishmanial potential of fused 5-(pyrazin-2-yl)-4H-1,2,4-triazole-3-thiols: Synthesis, biological evaluations and computational studies. , 2017, Bioorganic & medicinal chemistry letters.

[66]  Mamdouh M. Ali,et al.  New Coumarin Derivatives as Anti‐Breast and Anti‐Cervical Cancer Agents Targeting VEGFR‐2 and p38α MAPK , 2017, Archiv der Pharmazie.

[67]  A. Korkegian,et al.  The synthesis and evaluation of triazolopyrimidines as anti-tubercular agents , 2017, Bioorganic & medicinal chemistry.

[68]  A. Ray,et al.  1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. , 2017, Bioorganic & medicinal chemistry.

[69]  Chong-kyo Lee,et al.  Enterovirus inhibitory activity of C-8-tert-butyl substituted 4-aryl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-ones. , 2017, Bioorganic & medicinal chemistry letters.

[70]  S. Samshuddin,et al.  A Review on 1,2,4-Triazole Derivatives as Corrosion Inhibitors , 2017, Journal of Bio- and Tribo-Corrosion.

[71]  Xiaoping Bao,et al.  Synthesis of novel 1,2,4-triazole derivatives containing the quinazolinylpiperidinyl moiety and N-(substituted phenyl)acetamide group as efficient bactericides against the phytopathogenic bacterium Xanthomonas oryzae pv. oryzae , 2017 .

[72]  M. Steinmetz,et al.  Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin. , 2017, Cell chemical biology.

[73]  S. Garneau‐Tsodikova,et al.  Novel alkylated azoles as potent antifungals. , 2017, European journal of medicinal chemistry.

[74]  Inci Kazkayasi,et al.  Design and Synthesis of 1,2,4‐Triazolo[3,2‐b]‐1,3,5‐thiadiazine Derivatives as a Novel Template for Analgesic/Anti‐Inflammatory Activity , 2017, Archiv der Pharmazie.

[75]  Wen-long Huang,et al.  Discovery of novel 2-substituted-4-(2-fluorophenoxy) pyridine derivatives possessing pyrazolone and triazole moieties as dual c-Met/VEGFR-2 receptor tyrosine kinase inhibitors. , 2017, Bioorganic chemistry.

[76]  F. Yılmaz,et al.  Design, Synthesis, and Biological Evaluation of Coumarin–Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents , 2017, Archiv der Pharmazie.

[77]  Jing Zhao,et al.  Design, synthesis, and in vitro evaluation of novel antifungal triazoles. , 2017, Bioorganic & medicinal chemistry letters.

[78]  Heba S. A. Elzahabi Synthesis, Characterization, and Biological Evaluation of Some Novel Quinoxaline Derivatives as Antiviral Agents , 2017, Archiv der Pharmazie.

[79]  S. Botros,et al.  Synthesis, Characterization and Cytotoxicity of Substituted [1]Benzothieno[3,2-e][1,2,4]triazolo [4,3-a]pyrimidines. , 2017, Acta chimica Slovenica.

[80]  B. Wang,et al.  Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors. , 2017, European journal of medicinal chemistry.

[81]  Michelle C. Schaeffer,et al.  Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. , 2017, Journal of medicinal chemistry.

[82]  Qingsong Liu,et al.  Discovery of imidazopyridine derivatives as novel c-Met kinase inhibitors: Synthesis, SAR study, and biological activity. , 2017, Bioorganic chemistry.

[83]  R. Sreenivasulu,et al.  Synthesis, antitumor evaluation, and molecular docking studies of indole–indazolyl hydrazide–hydrazone derivatives , 2017, Monatshefte für Chemie - Chemical Monthly.

[84]  W. Duan,et al.  Synthesis and Antifungal Activity of Novel Myrtenal-Based 4-Methyl-1,2,4-triazole-thioethers , 2017, Molecules.

[85]  Hong-min Liu,et al.  Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors. , 2017, European journal of medicinal chemistry.

[86]  A. Duerkop,et al.  Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents. , 2017, European journal of medicinal chemistry.

[87]  Suat Sarı,et al.  New (arylalkyl)azole derivatives showing anticonvulsant effects could have VGSC and/or GABAAR affinity according to molecular modeling studies. , 2016, European journal of medicinal chemistry.

[88]  Phoebe F. Lamie,et al.  Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study. , 2016, European journal of medicinal chemistry.

[89]  H. S. Rosenzweig,et al.  Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity , 2016, European journal of medicinal chemistry.

[90]  Jinxing Hu,et al.  Design, synthesis and structure-activity relationships of novel 4-phenoxyquinoline derivatives containing 1,2,4-triazolone moiety as c-Met kinase inhibitors. , 2016, European journal of medicinal chemistry.

[91]  David M. Shackleford,et al.  A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. , 2016, ACS infectious diseases.

[92]  E. Ferreira,et al.  Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues. , 2016, European journal of medicinal chemistry.

[93]  E. De Clercq,et al.  Synthesis and antiproliferative evaluation of novel 2-(4H-1,2,4-triazole-3-ylthio)acetamide derivatives as inducers of apoptosis in cancer cells. , 2016, European journal of medicinal chemistry.

[94]  Haibing Li,et al.  Synthesis, antitumor evaluation and 3D-QSAR studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives. , 2016, Bioorganic & medicinal chemistry letters.

[95]  W. Liu,et al.  Synthesis and aromatase inhibitory evaluation of 4-N-nitrophenyl substituted amino-4H-1,2,4-triazole derivatives. , 2016, Bioorganic & medicinal chemistry.

[96]  J. Bhatt,et al.  Microwave Assisted Synthesis of Pyrimidines in Ionic Liquid and Their Potency as Non‐Classical Malarial Antifolates , 2016, Archiv der Pharmazie.

[97]  B. Jayaram,et al.  Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies. , 2016, European journal of medicinal chemistry.

[98]  Glen Spraggon,et al.  Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness , 2016, Nature.

[99]  Zi-Ning Cui,et al.  Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors. , 2016, Bioorganic & medicinal chemistry letters.

[100]  Qiu Li,et al.  Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives. , 2016, Bioorganic & medicinal chemistry letters.

[101]  Jun Jiang,et al.  Synthesis, antitumor evaluation and molecular docking studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives. , 2016, Bioorganic & medicinal chemistry letters.

[102]  Jiayin Yuan,et al.  Poly(1-Vinyl-1,2,4-triazolium) Poly(Ionic Liquid)s: Synthesis and the Unique Behavior in Loading Metal Ions. , 2016, Macromolecular rapid communications.

[103]  A. Saeed,et al.  Unraveling the Alkaline Phosphatase Inhibition, Anticancer, and Antileishmanial Potential of Coumarin–Triazolothiadiazine Hybrids: Design, Synthesis, and Molecular Docking Analysis , 2016, Archiv der Pharmazie.

[104]  Yechun Xu,et al.  Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor. , 2016, European journal of medicinal chemistry.

[105]  M. Lecoeur,et al.  Synthesis of triazoloquinazolinone based compounds as tubulin polymerization inhibitors and vascular disrupting agents. , 2016, European journal of medicinal chemistry.

[106]  Haotian Zhang,et al.  Discovery of novel diaryl urea derivatives bearing a triazole moiety as potential antitumor agents. , 2016, European journal of medicinal chemistry.

[107]  M. Pasca,et al.  Triazolophthalazines: Easily Accessible Compounds with Potent Antitubercular Activity , 2016, ChemMedChem.

[108]  Shiben Wang,et al.  Design, synthesis, and evaluation of the anticonvulsant and antidepressant activities of pyrido[2,3-d]pyrimidine derivatives , 2016, Medicinal Chemistry Research.

[109]  G. Kus,et al.  Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies. , 2016, European journal of medicinal chemistry.

[110]  P. Rathod,et al.  Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity , 2016, Journal of medicinal chemistry.

[111]  Xuejun Jin,et al.  Synthesis and anti-inflammatory activity evaluation of a novel series of 6-phenoxy-[1,2,4]triazolo[3,4-a]phthalazine-3-carboxamide derivatives. , 2016, Bioorganic & medicinal chemistry letters.

[112]  Dachuan Liu,et al.  Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives as Potential Anticonvulsant Agents , 2016, Molecules.

[113]  K. Rex,et al.  Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity. , 2016, Journal of medicinal chemistry.

[114]  J. Xu,et al.  Discovery of novel hybrids of diaryl-1,2,4-triazoles and caffeic acid as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase for cancer therapy. , 2016, European journal of medicinal chemistry.

[115]  M. Hashemzadeh,et al.  Triazole antifungals: a review. , 2015, Drugs of today.

[116]  Guo-Hua Gong,et al.  Synthesis of 4-Phenylthieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidine-5(4H)-one Derivatives and Evaluation of Their Anti-inflammatory Activity , 2015 .

[117]  Guoning Zhang,et al.  SAR studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of Mtb shikimate dehydrogenase for the development of novel antitubercular agents , 2015 .

[118]  Wen-wei You,et al.  Design, synthesis and biological evaluation of novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines bearing furan and thiophene nucleus. , 2015, European journal of medicinal chemistry.

[119]  C. S. Reddy,et al.  Synthesis and Antibacterial Activity of N‐Substituted‐[1,2,4]triazoles and 1,2,4‐Triazole[3,4‐b][1,3,4]thiadiazines. , 2015 .

[120]  E. Chatelain,et al.  Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation. , 2015, Bioorganic & medicinal chemistry.

[121]  Laura M Sanz,et al.  Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials. , 2015, Journal of Medicinal Chemistry.

[122]  Fu-nan Li,et al.  Synthesis and Anticonvulsant Activity Evaluation of 4‐Phenyl‐[1,2,4]triazolo[4,3‐a]quinazolin‐5(4H)‐one and Its Derivatives , 2015, Archiv der Pharmazie.

[123]  M. Wiese,et al.  Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives. , 2015, Bioorganic & medicinal chemistry letters.

[124]  M. Polz-Dacewicz,et al.  Search for factors affecting antibacterial activity and toxicity of 1,2,4-triazole-ciprofloxacin hybrids. , 2015, European journal of medicinal chemistry.

[125]  B. C. Tel,et al.  Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies. , 2015, Bioorganic & medicinal chemistry.

[126]  L. Goracci,et al.  A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits. , 2015, Journal of medicinal chemistry.

[127]  Zheng Xu,et al.  Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group , 2015, Drug design, development and therapy.

[128]  E. De Clercq,et al.  Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches. , 2015, European journal of medicinal chemistry.

[129]  K. Rex,et al.  Discovery of potent and selective 8-fluorotriazolopyridine c-Met inhibitors. , 2015, Journal of medicinal chemistry.

[130]  F. Ahmadi,et al.  Novel agonists of benzodiazepine receptors: design, synthesis, binding assay and pharmacological evaluation of 1,2,4-triazolo[1,5-a]pyrimidinone and 3-amino-1,2,4-triazole derivatives. , 2015, Bioorganic & medicinal chemistry.

[131]  Hanan M. Refaat,et al.  Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives. , 2015, European journal of medicinal chemistry.

[132]  E. Chatelain,et al.  Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents. , 2015, Journal of medicinal chemistry.

[133]  Doaa A E Issa,et al.  Design, synthesis and biological evaluation of novel 1,2,4-triazolo and 1,2,4-triazino[4,3- a ]quinoxalines as potential anticancer and antimicrobial agents , 2015 .

[134]  J. Nicolas,et al.  The Selective Intravenous Inhibitor of the MET Tyrosine Kinase SAR125844 Inhibits Tumor Growth in MET-Amplified Cancer , 2014, Molecular Cancer Therapeutics.

[135]  H. S. Rosenzweig,et al.  Novel nitro(triazole/imidazole)-based heteroarylamides/sulfonamides as potential antitrypanosomal agents. , 2014, European journal of medicinal chemistry.

[136]  A. Mavrova,et al.  Synthesis and antiproliferative activity of some new thieno[2,3-d]pyrimidin-4(3H)-ones containing 1,2,4-triazole and 1,3,4-thiadiazole moiety. , 2014, European journal of medicinal chemistry.

[137]  N. Y. Megally Abdo,et al.  Synthesis of novel 1,2,4-triazoles, triazolothiadiazines and triazolothiadiazoles as potential anticancer agents. , 2014, European journal of medicinal chemistry.

[138]  M. Kołaczkowski,et al.  Studies on the anticonvulsant activity of 4-alkyl-1,2,4-triazole-3-thiones and their effect on GABAergic system. , 2014, European journal of medicinal chemistry.

[139]  S. Alfei,et al.  1,8-Naphthyridines IX. Potent anti-inflammatory and/or analgesic activity of a new group of substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides, of some their Mannich base derivatives and of one novel substituted 5-amino-10-oxo-10H-pyrimido[1,2-a][1,8]naphthyridine-6-carboxami , 2014, European journal of medicinal chemistry.

[140]  Peng Zhan,et al.  Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 2: discovery of novel [1,2,4]Triazolo[1,5-a]pyrimidines using a structure-guided core-refining approach. , 2014, European journal of medicinal chemistry.

[141]  Liying Ma,et al.  Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives. , 2014, European journal of medicinal chemistry.

[142]  Fu-nan Li,et al.  Synthesis and anticonvulsant activity of novel purine derivatives. , 2014, European journal of medicinal chemistry.

[143]  Bharathkumar Inturi,et al.  Design, synthesis and 3D-QSAR studies of new diphenylamine containing 1,2,4-triazoles as potential antitubercular agents. , 2014, European journal of medicinal chemistry.

[144]  H. S. Rosenzweig,et al.  Nitrotriazole- and Imidazole-Based Amides and Sulfonamides as Antitubercular Agents , 2014, Antimicrobial Agents and Chemotherapy.

[145]  T. Kaoud,et al.  Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies. , 2014, European journal of medicinal chemistry.

[146]  Mohamed Fares,et al.  Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest. , 2014, European journal of medicinal chemistry.

[147]  M. Kołaczkowski,et al.  Studies on the Anticonvulsant Activity and Influence on GABA-ergic Neurotransmission of 1,2,4-Triazole-3-thione-Based Compounds , 2014, Molecules.

[148]  X. Zhai,et al.  Design and synthesis of novel 2-(4-(2-(dimethylamino)ethyl)-4H-1,2,4-triazol-3-yl)pyridines as potential antitumor agents. , 2014, European journal of medicinal chemistry.

[149]  Ming-Xia Song,et al.  Synthesis and Anticonvulsant Evaluation of some New 6-(Substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice , 2014, Iranian journal of pharmaceutical research : IJPR.

[150]  Jeremy N. Burrows,et al.  Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors , 2014, Journal of medicinal chemistry.

[151]  Rajeev K. Singla,et al.  Insights on the antioxidant potential of 1, 2, 4-triazoles: synthesis, screening & QSAR studies. , 2014, Current drug metabolism.

[152]  Yan Zou,et al.  Synthesis and evaluation of novel azoles as potent antifungal agents. , 2014, Bioorganic & medicinal chemistry letters.

[153]  Eman A M Beshr,et al.  1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity. , 2014, European journal of medicinal chemistry.

[154]  Yuan-Ying Jiang,et al.  Triazole derivatives with improved in vitro antifungal activity over azole drugs , 2014, Drug design, development and therapy.

[155]  P. Yogeeswari,et al.  Synthesis and antimycobacterial activities of some new thiazolylhydrazone derivatives. , 2014, Bioorganic & medicinal chemistry letters.

[156]  Xu-dong Cao,et al.  Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2,4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models , 2014, Medicinal Chemistry Research.

[157]  C. Supuran,et al.  Benzenesulfonamide bearing 1,2,4-triazole scaffolds as potent inhibitors of tumor associated carbonic anhydrase isoforms hCA IX and hCA XII. , 2014, Bioorganic & medicinal chemistry.

[158]  Ming-Xia Song,et al.  Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4 , 5-dihydrobenzo [ b ] [ 1 , 2 , 4 ] triazolo [ 4 , 3-d ] [ 1 , 4 ] thiazepine derivatives , 2014 .

[159]  Xufeng Cao,et al.  Design , Synthesis , and Structure − Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility , 2014 .

[160]  Xiang Li,et al.  Synthesis, antifungal activities and molecular docking studies of novel 2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl dithiocarbamates. , 2014, European journal of medicinal chemistry.

[161]  Xin Xie,et al.  Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists. , 2014, European journal of medicinal chemistry.

[162]  S. Aaronson,et al.  Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. , 2014, Journal of medicinal chemistry.

[163]  E. Menteşe,et al.  Synthesis of Some New 1,2,4‐Triazole Derivatives Starting from 3‐(4‐Chlorophenyl)‐5‐(4‐methoxybenzyl)‐4H‐1,2,4‐triazol with Anti‐Lipase and Anti‐Urease Activities , 2014, Archiv der Pharmazie.

[164]  Ming-Xia Song,et al.  Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. , 2014, European journal of medicinal chemistry.

[165]  G. Abuo-Rahma,et al.  1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities. , 2014, European journal of medicinal chemistry.

[166]  S. W. Park,et al.  Access to a new class of biologically active quinoline based 1,2,4-triazoles. , 2014, European journal of medicinal chemistry.

[167]  Cheng-He Zhou,et al.  Synthesis and biological evaluation of α-triazolyl chalcones as a new type of potential antimicrobial agents and their interaction with calf thymus DNA and human serum albumin. , 2014, European journal of medicinal chemistry.

[168]  W. de Souza,et al.  In Vitro Activity of the Antifungal Azoles Itraconazole and Posaconazole against Leishmania amazonensis , 2013, PloS one.

[169]  S. Maddila,et al.  Synthesis and Anti-Inflammatory Activity of Fused 1,2,4-triazolo-[3,4-b] [1,3,4]thiadiazole Derivatives of Phenothiazine , 2013 .

[170]  E. Chatelain,et al.  Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents. , 2013, Bioorganic & medicinal chemistry.

[171]  Liqiang Wu,et al.  Regioselective synthesis of 6-aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-7,8-diones as potent antitumoral agents. , 2013, Bioorganic & medicinal chemistry letters.

[172]  Jing Xu,et al.  Synthesis and anticancer activity evaluation of a series of [1,2,4]triazolo[1,5-a]pyridinylpyridines in vitro and in vivo. , 2013, European journal of medicinal chemistry.

[173]  W. Chui,et al.  A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities. , 2013, European journal of medicinal chemistry.

[174]  K. Mohamed,et al.  Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study. , 2013, European journal of medicinal chemistry.

[175]  Shuai Zhang,et al.  Synthesis and antimicrobical evaluation of a novel class of 1,3,4-thiadiazole: derivatives bearing 1,2,4-triazolo[1,5-a]pyrimidine moiety. , 2013, European journal of medicinal chemistry.

[176]  Rongmei Geng,et al.  Synthesis and biological evaluation of a class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA. , 2013, Bioorganic & medicinal chemistry letters.

[177]  Shengzheng Wang,et al.  Discovery of highly potent triazole antifungal derivatives by heterocycle-benzene bioisosteric replacement. , 2013, European journal of medicinal chemistry.

[178]  L. Freire-de-Lima,et al.  Design, Synthesis and Trypanocidal Evaluation of Novel 1,2,4-Triazoles-3-thiones Derived from Natural Piperine , 2013, Molecules.

[179]  A. Isloor,et al.  Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives , 2013 .

[180]  A. Husain,et al.  Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: new anticancer agents. , 2013, European journal of medicinal chemistry.

[181]  I. M. El-Ashmawy,et al.  Synthesis and biological evaluation of thieno [2',3':4,5]pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a]pyrimidines as anti-inflammatory and analgesic agents. , 2013, European journal of medicinal chemistry.

[182]  B. Song,et al.  Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety , 2013, Chemistry Central Journal.

[183]  N. Khalil,et al.  Synthesis and anticonvulsant activity of new phenytoin derivatives. , 2013, European journal of medicinal chemistry.

[184]  J. Luszczki,et al.  Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles. , 2013, European journal of medicinal chemistry.

[185]  M. Polz-Dacewicz,et al.  Synthesis and in vitro activity of 1,2,4-triazole-ciprofloxacin hybrids against drug-susceptible and drug-resistant bacteria. , 2013, European journal of medicinal chemistry.

[186]  Antonio M. Rodríguez,et al.  Optical waveguides from 4-aryl-4H-1,2,4-triazole-based supramolecular structures. , 2013, Chemical communications.

[187]  B. C. Tel,et al.  Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance. , 2012, European journal of medicinal chemistry.

[188]  V. K. Pandey,et al.  Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents , 2012, ISRN organic chemistry.

[189]  Rongmei Geng,et al.  Design, synthesis and evaluation of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents. , 2012, Bioorganic & medicinal chemistry letters.

[190]  I. M. El-Ashmawy,et al.  Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents. , 2012, European journal of medicinal chemistry.

[191]  Morkos A. Henen,et al.  [1,2,4]Triazolo[4,3-a]quinoxaline: synthesis, antiviral, and antimicrobial activities , 2012, Medicinal Chemistry Research.

[192]  Wen-wei You,et al.  One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation. , 2012, European journal of medicinal chemistry.

[193]  B. Poojary,et al.  Facile synthesis, cytotoxic and antimicrobial activity studies of a new group of 6-aryl-3-[4-(methylsulfonyl)benzyl]-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines. , 2012, European journal of medicinal chemistry.

[194]  A. Guirado,et al.  Synthesis and biological evaluation of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines as inhibitors of TNF-α and IL-6. , 2012, European journal of medicinal chemistry.

[195]  F. Bărbuceanu,et al.  New heterocyclic compounds from 1,2,4-triazole and 1,3,4-thiadiazole class bearing diphenylsulfone moieties. Synthesis, characterization and antimicrobial activity evaluation. , 2012, European journal of medicinal chemistry.

[196]  Shengzheng Wang,et al.  Design, synthesis and structure-activity relationships of new triazole derivatives containing N-substituted phenoxypropylamino side chains. , 2012, European journal of medicinal chemistry.

[197]  Hai-Kui Yang,et al.  Synthesis and cytotoxicity of 3,4-disubstituted-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazoles and novel 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives bearing 3,4,5-trimethoxyphenyl moiety. , 2012, Bioorganic & medicinal chemistry letters.

[198]  E. Chatelain,et al.  Novel 3-nitro-1H-1,2,4-triazole-based amides and sulfonamides as potential antitrypanosomal agents. , 2012, Journal of medicinal chemistry.

[199]  B. Poojary,et al.  Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. , 2012, European journal of medicinal chemistry.

[200]  F. Bărbuceanu,et al.  New heterocyclic compounds from 1,2,4-triazole and 1,3,4-thiadiazole class bearing diphenylsulfone moieties. Synthesis, characterization and antimicrobial activity evaluation. , 2012, European journal of medicinal chemistry.

[201]  C. Potamitis,et al.  Synthesis of novel sulfonamide-1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles, as potential antibacterial and antifungal agents. Biological evaluation and conformational analysis studies. , 2012, Bioorganic & medicinal chemistry.

[202]  S. Wilkinson,et al.  Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents. , 2011, Journal of medicinal chemistry.

[203]  Virender Kumar,et al.  Copper(II) chloride mediated synthesis and DNA photocleavage activity of 1-aryl/heteroaryl-4-substituted-1,2,4-triazolo[4,3-a]quinoxalines. , 2011, European journal of medicinal chemistry.

[204]  Shengzheng Wang,et al.  Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism. , 2011, European journal of medicinal chemistry.

[205]  Yankun Hou,et al.  Synthesis and antitumor activity of 1,2,4-triazoles having 1,4-benzodioxan fragment as a novel class of potent methionine aminopeptidase type II inhibitors. , 2011, Bioorganic & medicinal chemistry.

[206]  E. De Clercq,et al.  Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors. , 2011, European journal of medicinal chemistry.

[207]  O. Prakash,et al.  Synthesis and biological evaluation of dihydroindeno and indeno [1,2-e] [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines as antimicrobial agents. , 2011, European journal of medicinal chemistry.

[208]  Simon J F Macdonald,et al.  Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS). , 2011, ACS medicinal chemistry letters.

[209]  A. Shabaraya,et al.  Synthesis, characterization and pharmacological activity of 4-{[1-substituted aminomethyl-4-arylideneamino-5-sulfanyl-4,5-dihydro-1H-1,2,4-triazol-3-yl]methyl}-2H-1,4-benzothiazin-3(4H)-ones. , 2011, European journal of medicinal chemistry.

[210]  R. Kumar,et al.  Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives. , 2011, European journal of medicinal chemistry.

[211]  David M. Shackleford,et al.  Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential. , 2011, Journal of medicinal chemistry.

[212]  Yan Zou,et al.  Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents. , 2011, Bioorganic & medicinal chemistry letters.

[213]  Ming-Xia Song,et al.  Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives. , 2011, European journal of medicinal chemistry.

[214]  Yan Zou,et al.  Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. , 2011, European journal of medicinal chemistry.

[215]  David M. Shackleford,et al.  Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice. , 2011, Journal of medicinal chemistry.

[216]  Cheng‐He Zhou,et al.  Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents. , 2011, Bioorganic & medicinal chemistry letters.

[217]  Honggang Hu,et al.  Synthesis and Antifungal Evaluation of Novel Triazole Derivatives as Inhibitors of Cytochrome P450 14α-Demethylase. , 2011 .

[218]  Shengzheng Wang,et al.  Novel conformationally restricted triazole derivatives with potent antifungal activity. , 2010, European journal of medicinal chemistry.

[219]  Y. Na Synthesis and Activity of Novel Indole Linked Triazole Derivatives as Antifungal Agents , 2010 .

[220]  G. V. Suresh Kumar,et al.  Synthesis and pharmacological evaluation of clubbed isopropylthiazole derived triazolothiadiazoles, triazolothiadiazines and mannich bases as potential antimicrobial and antitubercular agents. , 2010, European journal of medicinal chemistry.

[221]  Honggang Hu,et al.  Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. , 2010, European journal of medicinal chemistry.

[222]  Cheng‐He Zhou,et al.  Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents. , 2010, European journal of medicinal chemistry.

[223]  A. Abu‐Hashem,et al.  Synthesis of 3-((2,4-Dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as Antiinflammatory and Molluscicidal Agents. , 2010 .

[224]  I. Crandall,et al.  Anti-Plasmodium activity of imidazolium and triazolium salts. , 2010, Bioorganic & medicinal chemistry.

[225]  Xianqing Deng,et al.  Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity. , 2010, European journal of medicinal chemistry.

[226]  V. Ballabeni,et al.  1,8-Naphthyridines. Part 8. Novel 5-Aminoimidazo[1,2-a][1,8]naphthyridine-6-carboxamide and 5-Amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamide Derivatives Showing Potent Analgesic or Antiinflammatory Activity, Respectively, and Completely Devoid of Acute Gastrolesivity. , 2010 .

[227]  G. V. Suresh Kumar,et al.  Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents. , 2010, European journal of medicinal chemistry.

[228]  A. Abu‐Hashem,et al.  Synthesis of 3-((2,4-dichlorophenoxy)methyl)-1,2,4-triazolo(thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents. , 2010, European journal of medicinal chemistry.

[229]  Xianqing Deng,et al.  Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine. , 2010, European journal of medicinal chemistry.

[230]  A. Brancale,et al.  Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues. , 2010, Journal of medicinal chemistry.

[231]  N. J. Gaikwad,et al.  Synthesis and Antimycobacterial Activity of Azetidine‐, Quinazoline‐, and Triazolo‐thiadiazole‐containing Pyrazines , 2010, Archiv der Pharmazie.

[232]  P. E. Russell A century of fungicide evolution , 2005, The Journal of Agricultural Science.

[233]  G. Dawson,et al.  3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2, α3, and α5-Subtype Binding Selectivity over α1 , 2004 .

[234]  K. Parang,et al.  Current targets for anticancer drug discovery. , 2003, Current drug targets.

[235]  M. Vincent,et al.  Tautomerism of 1,2,3- and 1,2,4-triazole in the gas phase and in aqueous solution : a combined ab initio quantum mechanics and free energy perturbation study , 1990 .

[236]  D. Sunil,et al.  1,2,3/1,2,4-Triazole containing liquid crystalline materials: An up-to-date review of their synthetic design and mesomorphic behavior , 2020 .

[237]  Yuan-Ying Jiang,et al.  Molecular docking, design, synthesis and antifungal activity study of novel triazole derivatives. , 2018, European journal of medicinal chemistry.

[238]  Guoning Zhang,et al.  Preliminary SAR and biological evaluation of antitubercular triazolothiadiazine derivatives against drug-susceptible and drug-resistant Mtb strains. , 2017, Bioorganic & medicinal chemistry.

[239]  A. Abu‐Hashem,et al.  Synthesis of novel 1, 2, 4-triazolopyrimidines and their evaluation as antimicrobial agents , 2016, Medicinal Chemistry Research.

[240]  B. Wang,et al.  Design, Synthesis and Evaluation of Triazole‐Pyrimidine Analogues as SecA Inhibitors , 2016, ChemMedChem.

[241]  P. Dixit,et al.  Hybrid triazoles: Design and synthesis as potential dual inhibitor of growth and efflux inhibition in tuberculosis. , 2016, European journal of medicinal chemistry.

[242]  K. Bhat,et al.  Some novel Schiff bases of [1,2,4]triazole bearing haloarene moiety—synthesis and evaluation of antituberculosis properties and neutrophil function test , 2015, Medicinal Chemistry Research.

[243]  K. R. Desai,et al.  Synthesis of novel sulfonamides as potential antibacterial, antifungal and antimalarial agents , 2015 .

[244]  Huang Guoqiang,et al.  Synthesis and antibacterial activity of novel[1,2,4]triazolo[3,4-h][1,8]naphthyridine-7-carboxylic acid derivatives , 2015 .

[245]  Eman K. A. Abdelall,et al.  Synthesis of novel chromene derivatives of expected antitumor activity. , 2013, European journal of medicinal chemistry.

[246]  Y Wang,et al.  Recent researches in triazole compounds as medicinal drugs. , 2012, Current medicinal chemistry.

[247]  N. Tawari,et al.  Novel 4H-1,2,4-triazol-3-yl cycloalkanols as potent antitubercular agents , 2012, Medicinal Chemistry Research.

[248]  A. Malm,et al.  Studies on the synthesis and antibacterial activity of 3,6-disubstituted 1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles. , 2012, European journal of medicinal chemistry.

[249]  V. Ballabeni,et al.  1,8-Naphthyridines VIII. Novel 5-aminoimidazo[1,2-a] [1,8]naphthyridine-6-carboxamide and 5-amino[1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamide derivatives showing potent analgesic or anti-inflammatory activity, respectively, and completely devoid of acute gastrolesivity. , 2010, European journal of medicinal chemistry.