Akt is required for Stat5 activation and mammary differentiation

[1]  L. Hennighausen,et al.  Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. , 2009, Genes & development.

[2]  S. Naber,et al.  Distinct roles of the three Akt isoforms in lactogenic differentiation and involution , 2008, Journal of cellular physiology.

[3]  Marie-Liesse Asselin-Labat,et al.  The Ets transcription factor Elf5 specifies mammary alveolar cell fate. , 2008, Genes & development.

[4]  L. Hennighausen,et al.  Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration , 2007, Hepatology.

[5]  Lewis C. Cantley,et al.  AKT/PKB Signaling: Navigating Downstream , 2007, Cell.

[6]  M. C. Rudolph,et al.  Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! , 2007, Breast Cancer Research.

[7]  M. C. Rudolph,et al.  Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. , 2007, Physiological genomics.

[8]  Katherine D Dugan,et al.  Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. , 2006, Cell metabolism.

[9]  B. Hemmings,et al.  Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies , 2006, Molecular and Cellular Biology.

[10]  L. Hennighausen,et al.  Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. , 2006, Blood.

[11]  J. Visvader,et al.  Socs2 and elf5 mediate prolactin-induced mammary gland development. , 2006, Molecular endocrinology.

[12]  L. Hennighausen,et al.  Stat5a/b are essential for normal lymphoid development and differentiation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[13]  W. Wahli,et al.  Dosage-Dependent Effects of Akt1/Protein Kinase Bα (PKBα) and Akt3/PKBγ on Thymus, Skin, and Cardiovascular and Nervous System Development in Mice , 2005, Molecular and Cellular Biology.

[14]  J. Testa,et al.  Perturbations of the AKT signaling pathway in human cancer , 2005, Oncogene.

[15]  Lothar Hennighausen,et al.  Information networks in the mammary gland , 2005, Nature Reviews Molecular Cell Biology.

[16]  J. Frahm,et al.  Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis , 2005, Development.

[17]  T. Ludwig,et al.  Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size , 2005, Molecular and Cellular Biology.

[18]  I. Kola,et al.  Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation , 2005, The EMBO journal.

[19]  C. Clevenger.  Roles and regulation of stat family transcription factors in human breast cancer. , 2004, The American journal of pathology.

[20]  C. Deng,et al.  Inactivation of Stat5 in Mouse Mammary Epithelium during Pregnancy Reveals Distinct Functions in Cell Proliferation, Survival, and Differentiation , 2004, Molecular and Cellular Biology.

[21]  H. Rui,et al.  Impaired Alveologenesis and Maintenance of Secretory Mammary Epithelial Cells in Jak2 Conditional Knockout Mice , 2004, Molecular and Cellular Biology.

[22]  Jennifer Skeen,et al.  Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. , 2003, Genes & development.

[23]  Lothar Hennighausen,et al.  Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[24]  S. Hankinson,et al.  The role of prolactin in mammary carcinoma. , 2003, Endocrine reviews.

[25]  L. Hennighausen,et al.  Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. , 2002, Molecular Endocrinology.

[26]  David S. Park,et al.  Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. , 2002, Molecular biology of the cell.

[27]  L. Hennighausen,et al.  PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. , 2002, The Journal of clinical investigation.

[28]  L. Hennighausen,et al.  Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. , 2002, Development.

[29]  L. Hennighausen,et al.  Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. , 2002, Molecular endocrinology.

[30]  R. Glazer,et al.  Delayed mammary gland involution in MMTV-AKT1 transgenic mice , 2002, Oncogene.

[31]  L. Hennighausen,et al.  Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium , 2001, The Journal of cell biology.

[32]  M. Birnbaum,et al.  Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice* , 2001, The Journal of Biological Chemistry.

[33]  I. Roninson,et al.  Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. , 2001, Genes & development.

[34]  S. Anderson,et al.  Mammary gland involution is delayed by activated Akt in transgenic mice. , 2001, Molecular endocrinology.

[35]  K. Kaestner,et al.  Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ) , 2001 .

[36]  R. Cardiff,et al.  Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression , 2001, Molecular and Cellular Biology.

[37]  S. Nishikawa,et al.  Lactation defect in mice lacking the helix–loop–helix inhibitor Id2 , 2000, The EMBO journal.

[38]  L. Berliner,et al.  α‐Lactalbumin: structure and function , 2000 .

[39]  Michael P. Brown,et al.  Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.

[40]  R. Snell,et al.  Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[41]  L. Hennighausen,et al.  Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.

[42]  B. Vonderhaar,et al.  Role of growth hormone and insulin-like growth factor-I in mammary development. , 1993, Endocrinology.

[43]  J. Testa,et al.  Activation of AKT kinases in cancer: implications for therapeutic targeting. , 2005, Advances in cancer research.

[44]  J. Rosen,et al.  Regulation of milk protein gene expression. , 1999, Annual review of nutrition.

[45]  P. Kelly,et al.  Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. , 1997, Genes & development.