Dual role for p16 in the metastasis process of HPV positive head and neck cancers

[1]  J. Kaski,et al.  Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers , 2015, British Journal of Cancer.

[2]  A. Eisbruch,et al.  Patterns of nodal metastasis and prognosis in human papillomavirus–positive oropharyngeal squamous cell carcinoma , 2014, Head & neck.

[3]  D. Klimstra,et al.  p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells , 2013, PloS one.

[4]  Wei Xu,et al.  Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  H. Quon,et al.  Controversies in treatment deintensification of human papillomavirus-associated oropharyngeal carcinomas: should we, how should we, and for whom? , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  A. Eisbruch,et al.  Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status , 2012, Head & neck.

[7]  A. Aboussekhra,et al.  p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition. , 2012, Neoplasia.

[8]  K. Ang,et al.  Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  Wei Xu,et al.  Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation. , 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[10]  A. Mazo,et al.  p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors , 2011, Oncogene.

[11]  R. Fisher,et al.  Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  D. Lowy,et al.  Prognostic implications of HPV in oropharyngeal cancer. , 2010, The New England journal of medicine.

[13]  P. Lassen.  The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[14]  F. Feng,et al.  Tobacco Use in Human Papillomavirus–Positive Advanced Oropharynx Cancer Patients Related to Increased Risk of Distant Metastases and Tumor Recurrence , 2010, Clinical Cancer Research.

[15]  A. Jemal,et al.  Cancer Statistics, 2009 , 2009, CA: a cancer journal for clinicians.

[16]  B. Garmy-Susini,et al.  Integrins in angiogenesis and lymphangiogenesis , 2008, Nature Reviews Cancer.

[17]  A. Forastiere,et al.  Head and neck cancer: changing epidemiology, diagnosis, and treatment. , 2008, Mayo Clinic proceedings.

[18]  A. Cmelak,et al.  Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. , 2008, Journal of the National Cancer Institute.

[19]  Peter Carmeliet,et al.  Angiogenesis in life, disease and medicine , 2005, Nature.

[20]  Satoshi Hirakawa,et al.  VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis , 2005, The Journal of experimental medicine.

[21]  H. Jin,et al.  Integrins: roles in cancer development and as treatment targets , 2004, British Journal of Cancer.

[22]  R. Fåhraeus,et al.  The p16INK4a tumour suppressor protein inhibits αvβ3 integrin‐mediated cell spreading on vitronectin by blocking PKC‐dependent localization of αvβ3 to focal contacts , 1999 .

[23]  Chandra L. Theesfeld,et al.  Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[24]  F. Sarkar,et al.  Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. , 1995, The Journal of clinical investigation.

[25]  J. Stockman.  Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer , 2012 .

[26]  J. Waldron,et al.  Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. , 2012, International journal of radiation oncology, biology, physics.

[27]  Ruud H. Brakenhoff,et al.  The molecular biology of head and neck cancer , 2011, Nature Reviews Cancer.

[28]  M. Makale,et al.  Methods to study lymphatic vessel integrins. , 2007, Methods in enzymology.

[29]  R. Fåhraeus,et al.  The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. , 1999, The EMBO journal.