Multiple roles of Adenomatous Polyposis Coli gene in Wnt Signalling - a Computational Model
暂无分享,去创建一个
[1] Mariann Bienz,et al. β-Catenin: A Pivot between Cell Adhesion and Wnt Signalling , 2005, Current Biology.
[2] Vivian S. W. Li,et al. Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. , 2015, American journal of physiology. Cell physiology.
[3] Uwe Benary,et al. Supporting Material : Paracrine and Autocrine Regulation of Gene Expression by Wnt-Inhibitor Dickkopf in Wild-type and Mutant Hepatocytes , 2017 .
[4] Andreas Hecht,et al. Mathematical modelling suggests a differential impact of β‐transducin repeat‐containing protein paralogues on Wnt/β‐catenin signalling dynamics , 2015, The FEBS journal.
[5] Paul Polakis,et al. Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β , 1998, Current Biology.
[6] Roland Krüger,et al. Model reduction and analysis of robustness for the Wnt/beta-catenin signal transduction pathway. , 2004, Genome informatics. International Conference on Genome Informatics.
[7] Reinhart Heinrich,et al. The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway , 2003, PLoS biology.
[8] W F Bodmer,et al. The ABC of APC. , 2001, Human molecular genetics.
[9] A. Chenn,et al. Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion , 2009, The Journal of cell biology.
[10] Jörg Stappert,et al. β‐catenin is a target for the ubiquitin–proteasome pathway , 1997 .
[11] Xi He,et al. Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism , 2002, Cell.
[12] T. Deroo,et al. A Positive Role of Cadherin in Wnt/β-Catenin Signalling during Epithelial-Mesenchymal Transition , 2011, PloS one.
[13] M. Taketo,et al. Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene , 2007, Journal of Cell Science.
[14] D. Kim,et al. A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK Pathways , 2007, Oncogene.
[15] V. Quaranta,et al. Cadherin-Bound β-Catenin Feeds into the Wnt Pathway upon Adherens Junctions Dissociation: Evidence for an Intersection between β-Catenin Pools , 2009, PloS one.
[16] Michael Kühl,et al. Extended analyses of the Wnt/β‐catenin pathway: Robustness and oscillatory behaviour , 2007, FEBS letters.
[17] Lea Goentoro,et al. Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. , 2009, Molecular cell.
[18] Kwang-Hyun Cho,et al. The APC network regulates the removal of mutated cells from colonic crypts. , 2014, Cell reports.
[19] D. Kimelman,et al. Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. , 2003, Genes & development.
[20] Mariann Bienz,et al. The APC tumour suppressor has a nuclear export function , 2000, Nature.
[21] Mariann Bienz,et al. The subcellular destinations of apc proteins , 2002, Nature Reviews Molecular Cell Biology.
[22] Mariann Bienz,et al. Adenomatous polyposis coli proteins and cell adhesion. , 2004, Current opinion in cell biology.
[23] B. Henderson,et al. APC shuttling to the membrane, nucleus and beyond. , 2008, Trends in cell biology.
[24] Olaf Wolkenhauer,et al. Analysing the impact of nucleo-cytoplasmic shuttling of β-catenin and its antagonists APC, Axin and GSK3 on Wnt/β-catenin signalling. , 2013, Cellular signalling.
[25] R. Nusse,et al. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities , 2017, Cell.
[26] Olaf Wolkenhauer,et al. Nucleo-cytoplasmic shuttling of APC can maximize β-catenin/TCF concentration. , 2011, Journal of theoretical biology.
[27] Raymond L. White,et al. APC‐mediated downregulation of β‐catenin activity involves nuclear sequestration and nuclear export , 2000, EMBO reports.
[28] F. Brembeck,et al. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. , 2004, Genes & development.
[29] F. Fagotto,et al. The ins and outs of APC and β‐catenin nuclear transport , 2002 .
[30] Emma M Schatoff,et al. WNT Signaling and Colorectal Cancer , 2017, Current Colorectal Cancer Reports.
[31] C. Gottardi,et al. β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling , 2010, PloS one.
[32] Kwang-Hyun Cho,et al. Wnt pathway mutations selected by optimal β‐catenin signaling for tumorigenesis , 2006 .
[33] Yinghao Wu,et al. Computational Modeling of the Interplay between Cadherin-Mediated Cell Adhesion and Wnt Signaling Pathway , 2014, PloS one.
[34] Hans Clevers,et al. Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex , 2012, Cell.
[35] Mariann Bienz,et al. Nuclear export of the APC tumour suppressor controls β‐catenin function in transcription , 2003, The EMBO journal.
[36] B. Henderson. Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover , 2000, Nature Cell Biology.
[37] Allon M Klein,et al. Kinetic Responses of β-Catenin Specify the Sites of Wnt Control , 2012, Science.
[38] Gary R. Mirams,et al. A multiple timescale analysis of a mathematical model of the Wnt/β-catenin signalling pathway , 2010, Journal of mathematical biology.
[39] S. Gallinger,et al. Familial adenomatous polyposis. , 2000, Seminars in surgical oncology.
[40] Xi He,et al. Adenomatous Polyposis Coli (APC) Differentially Regulates β-Catenin Phosphorylation and Ubiquitination in Colon Cancer Cells* , 2006, Journal of Biological Chemistry.
[41] J. Behrens,et al. Nucleo-cytoplasmic distribution of β-catenin is regulated by retention , 2006, Journal of Cell Science.
[42] M. Pignatelli,et al. β-catenin - A linchpin in colorectal carcinogenesis? , 2002 .
[43] Helen M Byrne,et al. Toward a quantitative understanding of the Wnt/β‐catenin pathway through simulation and experiment , 2013, Wiley interdisciplinary reviews. Systems biology and medicine.
[44] Nam-Chul Ha,et al. Mechanism of Phosphorylation-Dependent Binding of APC to β-Catenin and Its Role in β-Catenin Degradation , 2004 .
[45] C. Gottardi,et al. Phospho-regulation of β-Catenin Adhesion and Signaling Functions , 2007 .
[46] Daniel T Gillespie,et al. Stochastic simulation of chemical kinetics. , 2007, Annual review of physical chemistry.