Differences in nocturnal melatonin secretion between melancholic depressed patients and control subjects.

The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin. They also compared a second, separate group of 14 women and five men suffering from melancholic depression with seven healthy male control subjects and nine depressed women without melancholia. The melancholic patients had a significantly lower concentration of serum melatonin at 11:00 p.m. than either the control subjects or the nonmelancholic depressed patients. These findings support the possibility that the functioning of the pineal gland is altered in these patients.

[1]  L. Wetterberg,et al.  Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects , 1984, Psychoneuroendocrinology.

[2]  E. Robins,et al.  Pretreatment DST and hypothalamic-pituitary-adrenocortical function in depressed patients and comparison groups. A multicenter study. , 1984, Archives of general psychiatry.

[3]  L. Wetterberg.  The relationship between the pineal gland and the pituitary-adrenal axis in health, endocrine and psychiatric conditions , 1983, Psychoneuroendocrinology.

[4]  J. Halter,et al.  High levels of plasma catecholamines in dexamethasone-resistant depressed patients. , 1983, The American journal of psychiatry.

[5]  S. Koslow,et al.  CSF and urinary biogenic amines and metabolites in depression and mania. A controlled, univariate analysis. , 1983, Archives of general psychiatry.

[6]  J. Gillin.  Sleep Studies in Affective Illness: Diagnostic, Therapeutic, and Pathophysiological Implications , 1983 .

[7]  A. Frazer,et al.  Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum. , 1982, The Journal of pharmacology and experimental therapeutics.

[8]  T. Crow,et al.  REDUCED NOCTURNAL MELATONIN SECRETION IN CHRONIC SCHIZOPHRENIA: RELATIONSHIP TO BODY WEIGHT , 1982, Clinical endocrinology.

[9]  A. Schatzberg,et al.  Toward a biochemical classification of depressive disorders, V: Heterogeneity of unipolar depressions. , 1982, The American journal of psychiatry.

[10]  J. Amsterdam,et al.  The dexamethasone suppression test in outpatients with primary affective disorder and healthy control subjects. , 1982, The American journal of psychiatry.

[11]  B. Carroll.  The Dexamethasone Suppression Test for Melancholia , 1982, British Journal of Psychiatry.

[12]  D. Charney,et al.  Receptor sensitivity and the mechanism of action of antidepressant treatment. Implications for the etiology and therapy of depression. , 1981, Archives of general psychiatry.

[13]  D. Charney,et al.  Primary affective disorder criteria and the endogenous-reactive distinction. , 1980, Archives of general psychiatry.

[14]  L. Wetterberg,et al.  MELATONIN/CORTISOL RATIO IN DEPRESSION , 1979, The Lancet.

[15]  S. Markey,et al.  Analysis of melatonin in human plasma by gas chromatography negative chemical ionization mass spectrometry. , 1978, Science.

[16]  L. Wetterberg,et al.  EFFECT OF PROPRANOLOL ON SERUM-MELATONIN , 1977, The Lancet.

[17]  D. Kennaway,et al.  A specific radioimmunoassay for melatonin in biological tissue and fluids and its validation by gas chromatography-mass spectrometry. , 1977, Endocrinology.

[18]  R. Post,et al.  Urinary melatonin rhythms during sleep deprivation in depressed patients and normals. , 1977, Life sciences.

[19]  J J Bartko,et al.  ON THE METHODS AND THEORY OF RELIABILITY , 1976, The Journal of nervous and mental disease.

[20]  J. Schildkraut,et al.  The catecholamine hypothesis of affective disorders: a review of supporting evidence. , 1965, The American journal of psychiatry.

[21]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[22]  P. Linkowski,et al.  Simultaneous study of 24-hour patterns of melatonin and cortisol secretion in depressed patients. , 1982, Neuropsychobiology.

[23]  B. Weiss,et al.  Modulation of the beta-adrenergic receptor-adenylate cyclase system following acute and repeated treatment with antidepressants. , 1982, Advances in biochemical psychopharmacology.

[24]  W. Schloot,et al.  Melatonin Rhythms in Human Serum , 1981 .

[25]  A. Lewy.  Human Plasma Melatonin Studies: Effects of Light and Implications for Biological Rhythm Research , 1981 .

[26]  F. Goodwin,et al.  PLASMA MELATONIN IN MANIC-DEPRESSIVE ILLNESS , 1979 .

[27]  M. Moskowitz,et al.  Cervical spinal cord lesions disrupt the rhythm in human melatonin excretion. , 1978, Journal of neural transmission. Supplementum.

[28]  J. Axelrod.  Introductory remarks on regulation of pineal indoleamine synthesis. (Chairman's introduction). , 1978, Journal of neural transmission. Supplementum.

[29]  R. Moore.  Neural control of pineal function in mammals and birds. , 1978, Journal of neural transmission. Supplementum.

[30]  L. Wetterberg,et al.  Radioimmunoassay of melatonin: human serum and cerebrospinal fluid. , 1977, Hormone research.