Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia

Background : Iron deficiency anemia (IDA) and thalassemia trait (TT) are the most common forms of microcytic anemia. Some discrimination indices calculated from red blood cell indices are defined and used for rapid discrimination between TT and IDA. However, there has been no study carried out in which the validity of all of the defined indices are compared in the same patient groups. Youden's index is the most reliable method by which to measure the validity of a particular technique, because it takes into account both sensitivity and specificity.

[1]  S. Mcclure,et al.  Distinction of microcytic disorders: comparison of expert, numerical-discriminant, and microcomputer analysis. , 1989, Blood cells.

[2]  T J Hamblin,et al.  Differentiation of iron deficiency from thalassaemia trait. , 1973, Lancet.

[3]  P. Fraser,et al.  DISCRIMINATION BETWEEN IRON-DEFICIENCY AND HETEROZYGOUS-THALASSÆMIA SYNDROMES IN DIFFERENTIAL DIAGNOSIS OF MICROCYTOSIS , 1979, The Lancet.

[4]  G. Roberts,et al.  Red blood cell distribution width index in some hematologic diseases. , 1985, American journal of clinical pathology.

[5]  N. Pearce,et al.  Defining asthma in epidemiological studies. , 1999, The European respiratory journal.

[6]  D. Killer,et al.  Can automated haematology analysers discriminate thalassaemia from iron deficiency? , 1987, Acta Haematologica.

[7]  N. Olivieri.  The beta-thalassemias. , 1999, The New England journal of medicine.

[8]  Watts Gt.  Letter: Breast prostheses. , 1975 .

[9]  G. Klee,et al.  Routine erythrocyte measurements in diagnosis of iron-deficiency anemia and thalassemia minor. , 1976, American journal of clinical pathology.

[10]  R. Novak.  Red blood cell distribution width in pediatric microcytic anemias. , 1987, Pediatrics.

[11]  C. Chiu,et al.  Comparison of hemoglobin and red blood cell distribution width in the differential diagnosis of microcytic anemia. , 1992, Archives of pathology & laboratory medicine.

[12]  P. Visintainer,et al.  #262 Differentiating iron deficiency anemia from thalassemia minor by using an RDW-based index , 1999 .

[13]  J. M. Bevington,et al.  Iron deficiency and-or thalassaemia trait. , 1973, Lancet.

[14]  J. Bessman,et al.  Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor. , 1979, Blood.

[15]  S. Lal,et al.  A STRATEGY TO DETECT β-THALASSÆMIA MINOR , 1977, The Lancet.

[16]  P. Burney,et al.  What symptoms predict the bronchial response to histamine? Evaluation in a community survey of the bronchial symptoms questionnaire (1984) of the International Union Against Tuberculosis and Lung Disease. , 1989, International journal of epidemiology.

[17]  J. Bessman,et al.  Quantitative anisocytosis as a discriminant between iron deficiency and thalassemia minor , 1979 .

[18]  S. Bentley,et al.  The clinical utility of discriminant functions for the differential diagnosis of microcytic anemias. , 1989, Blood cells.

[19]  B. Wharton.  IRON DEFICIENCY IN CHILDREN: DETECTION AND PREVENTION , 1999, British journal of haematology.

[20]  M. Abrahamson.  Pulmonocardiac failure associated with deformity of the chest. , 1959, Lancet.

[21]  J. Hermans,et al.  Evaluation of microcytosis using serum ferritin and red blood cell distribution width , 1990, European journal of haematology.

[22]  M. Flynn,et al.  Limitations of red blood cell distribution width (RDW) in evaluation of microcytosis. , 1986, American journal of clinical pathology.

[23]  G. E. Simon,et al.  The measurement of free erythrocyte porphyrin (FEP) as a simple means of distinguishing iron deficiency from beta-thalassemia trait in subjects with microcytosis. , 1975, The Journal of laboratory and clinical medicine.

[24]  S. Lal,et al.  A strategy to detect beta-thalassaemia minor. , 1977, Lancet.

[25]  F. Gardner,et al.  Improved classification of anemias by MCV and RDW. , 1983, American journal of clinical pathology.

[26]  P. Dallman,et al.  Iron deficiency in infancy and childhood. , 1980, The American journal of clinical nutrition.

[27]  N. Olivieri.  The β-Thalassemias , 1999 .

[28]  F. Mastaglia,et al.  ABSENCE OF ACETYLCHOLINE RECEPTOR ANTIBODY IN RELATIVES OF MYASTHENIC PATIENTS , 1980, The Lancet.

[29]  R. Green,et al.  A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. , 1989, Blood cells.

[30]  P. Fraser,et al.  Differentiation of iron deficiency from thalassaemia trait by routine blood-count. , 1973, Lancet.