Comprehensive N-Methyl Scanning of a Potent Peptide Inhibitor of Malaria Invasion into Erythrocytes Leads to Pharmacokinetic Optimization of the Molecule

[1]  Horst Kessler,et al.  Improving oral bioavailability of peptides by multiple N-methylation: somatostatin analogues. , 2008, Angewandte Chemie.

[2]  A. Doig,et al.  N-Methylated peptide inhibitors of beta-amyloid aggregation and toxicity. Optimization of the inhibitor structure. , 2006, Biochemistry.

[3]  Erinna F. Lee,et al.  Binding Hot Spot for Invasion Inhibitory Molecules on Plasmodium falciparum Apical Membrane Antigen 1 , 2005, Infection and Immunity.

[4]  A. Thomas,et al.  Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells , 2004, Infection and Immunity.

[5]  R. Brownlee,et al.  An efficient synthesis of N-methyl amino acids by way of intermediate 5-oxazolidinones. , 2003, The Journal of organic chemistry.

[6]  P. Schubiger,et al.  Stabilization of neurotensin analogues: effect on peptide catabolism, biodistribution and tumor binding. , 2002, Nuclear medicine and biology.

[7]  Robert G. Ridley,et al.  Medical need, scientific opportunity and the drive for antimalarial drugs , 2002, Nature.

[8]  R. Anders,et al.  Specificity of the Protective Antibody Response to Apical Membrane Antigen 1 , 2001, Infection and Immunity.

[9]  J. Taylor,et al.  Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist. , 2001, Journal of medicinal chemistry.

[10]  P. S. Kim,et al.  Inhibiting HIV-1 Entry Discovery of D-Peptide Inhibitors that Target the gp41 Coiled-Coil Pocket , 1999, Cell.

[11]  R. Coppel,et al.  An alternative to serum for cultivation of Plasmodium falciparum in vitro. , 1997, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[12]  T. Scanlan,et al.  Site-Selective N-Methylation of Peptides on Solid Support , 1997 .

[13]  T. Vojkovský,et al.  Detection of secondary amines on solid phase. , 1995, Peptide research.

[14]  J. Le bras,et al.  Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay. , 1995, Experimental parasitology.

[15]  C. Lambros,et al.  Synchronization of Plasmodium falciparum erythrocytic stages in culture. , 1979, The Journal of parasitology.

[16]  W. Hancock,et al.  A new micro-test for the detection of incomplete coupling reactions in solid-phase peptide synthesis using 2,4,6-trinitrobenzenesulphonic acid. , 1976, Analytical biochemistry.

[17]  R. Anders,et al.  Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi. , 1998, Vaccine.

[18]  E. Giralt,et al.  Diketopiperazine Formation in Solid Phase Peptide Synthesis Using p‐Alkoxybenzyl Ester Resins and FMOC‐Amino Acids. , 1986 .