The role of hypoxia-induced factors in tumor progression.
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[1] G. Semenza,et al. HIF-1, O2, and the 3 PHDs How Animal Cells Signal Hypoxia to the Nucleus , 2001, Cell.
[2] P. Okunieff,et al. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.
[3] Oliver Thews,et al. Treatment resistance of solid tumors , 2001 .
[4] R. Wenger,et al. Cellular adaptation to hypoxia: O2‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O2‐regulated gene expression , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[5] R. Durand. Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. , 1991, International journal of radiation oncology, biology, physics.
[6] P. Ratcliffe,et al. Oxygen sensors and angiogenesis. , 2002, Seminars in cell & developmental biology.
[7] John E. Moulder,et al. Tumor hypoxia: its impact on cancer therapy , 2004, Cancer and Metastasis Reviews.
[8] N. Petrelli,et al. An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer. , 1995, Cancer research.
[9] P. Jaruga,et al. Oxidative DNA damage: assessment of the role in carcinogenesis, atherosclerosis, and acquired immunodeficiency syndrome. , 2002, Free radical biology & medicine.
[10] A. Koong,et al. Candidate genes for the hypoxic tumor phenotype. , 2000, Cancer research.
[11] M. Dewhirst,et al. Early wound healing exhibits cytokine surge without evidence of hypoxia. , 2000, Annals of surgery.
[12] P Vaupel,et al. Biological consequences of tumor hypoxia. , 2001, Seminars in oncology.
[13] J. Brown,et al. Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. , 2000, Molecular medicine today.
[14] P. Glazer,et al. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. , 2000, Cancer research.
[15] G. Semenza,et al. Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1* , 1996, The Journal of Biological Chemistry.
[16] David E. Housman,et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours , 1996, Nature.
[17] H. Shepard,et al. Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α , 1987, Nature.
[18] P. Carmeliet,et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis , 1998, Nature.
[19] G. Semenza,et al. HIF-1 and tumor progression: pathophysiology and therapeutics. , 2002, Trends in molecular medicine.
[20] G. Semenza,et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.
[21] A. Koong,et al. Hypoxia Causes the Activation of Nuclear Factor κB through the Phosphorylation of IκBα on Tyrosine Residues , 1994 .
[22] G. Semenza,et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. , 2003, Cancer research.
[23] L. Orci,et al. Proteolytic balance and capillary morphogenesis in vitro. , 1992, EXS.
[24] P. Glazer,et al. Mutagenesis induced by the tumor microenvironment. , 1998, Mutation research.
[25] A. Giaccia,et al. Hypoxic Stress Proteins: Survival of the Fittest. , 1996, Seminars in radiation oncology.
[26] L. Orci,et al. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. , 1991, Biochemical and biophysical research communications.
[27] G. Semenza,et al. Purification and Characterization of Hypoxia-inducible Factor 1 (*) , 1995, The Journal of Biological Chemistry.
[28] L. Loeb,et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. , 1992, The Journal of biological chemistry.
[29] G. Semenza,et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. , 1994, The Journal of biological chemistry.
[30] A. Osterborg. Recombinant human erythropoietin (rHuEPO) therapy in patients with cancer-related anaemia: what have we learned? , 1998, Medical oncology.
[31] G. Semenza,et al. Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression , 2000, Critical reviews in biochemistry and molecular biology.
[32] G. Semenza,et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[33] D. Hanahan,et al. Transgenic mouse models of tumour angiogenesis: the angiogenic switch, its molecular controls, and prospects for preclinical therapeutic models. , 1996, European journal of cancer.
[34] X. Leverve,et al. Cellular physiology and molecular events in hypoxia-induced apoptosis. , 1998, Anticancer research.
[35] J. Folkman. What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.
[36] G. Semenza,et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. , 2000, Genes & development.
[37] R. Czekay,et al. Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins , 2003, The Journal of cell biology.
[38] E. Rofstad. Microenvironment-induced cancer metastasis , 2000, International journal of radiation biology.
[39] R. Johnson,et al. Angiogenesis: the role of the microenvironment in flipping the switch. , 2001, Current opinion in genetics & development.
[40] P. Glazer,et al. Genetic instability induced by the tumor microenvironment. , 1996, Cancer research.
[41] P. Vaupel,et al. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. , 2001, Journal of the National Cancer Institute.
[42] G. Semenza. Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease , 2001, Pediatric Research.
[43] G. Semenza,et al. Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance. , 2001, The Journal of clinical investigation.
[44] F. Toledo,et al. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. , 1998, Molecular cell.
[45] P. Vaupel,et al. Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications. , 2002, Wiener medizinische Wochenschrift.
[46] A. Harris,et al. Hypoxia‐induced pathways in breast cancer , 2002, Microscopy research and technique.
[47] G. Semenza,et al. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation , 1992, Molecular and cellular biology.
[48] R. Hill,et al. Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. , 2001, Cancer research.
[49] P. Vaupel,et al. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. , 2004, The oncologist.
[50] Jessica Lo,et al. HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .
[51] A. Harris,et al. Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer , 2000, The Journal of pathology.
[52] P. Ratcliffe,et al. Activation of the HIF pathway in cancer. , 2001, Current opinion in genetics & development.
[53] R. Johnson,et al. The Response of c-Jun/AP-1 to Chronic Hypoxia Is Hypoxia-Inducible Factor 1α Dependent , 2002, Molecular and Cellular Biology.
[54] J. M. Arbeit,et al. Hypoxia-inducible Factor-1α Is a Positive Factor in Solid Tumor Growth , 2000 .