Protective effects of IRG1/itaconate on acute colitis through the inhibition of gasdermins-mediated pyroptosis and inflammation response

[1]  Hwan-Woo Park,et al.  Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate , 2022, International journal of molecular sciences.

[2]  K. Tao,et al.  Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways. , 2022, Free radical biology & medicine.

[3]  Yi He,et al.  Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis , 2022, Arthritis & Rheumatology (Hoboken, N.j.).

[4]  K. Tao,et al.  Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response. , 2021, Biochemical pharmacology.

[5]  Yikun Yao,et al.  Dysregulated Microbiota-Driven Gasdermin D Activation Promotes Colitis Development by Mediating IL-18 Release , 2021, Frontiers in Immunology.

[6]  Jinmin Zhao,et al.  Oroxylin A reduces osteoclast formation and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation. , 2021, Biochemical pharmacology.

[7]  K. Tao,et al.  4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response , 2021, Frontiers in Pharmacology.

[8]  S. Gong,et al.  Monocarboxylate Transporter 4 Triggered Cell Pyroptosis to Aggravate Intestinal Inflammation in Inflammatory Bowel Disease , 2021, Frontiers in Immunology.

[9]  Xiao-Zhong Yang,et al.  Itaconate aggravates experimental colitis. , 2021, Clinics and research in hepatology and gastroenterology.

[10]  A. Ahmadiani,et al.  LPS Preconditioning Attenuates Apoptosis Mechanism by Inhibiting NF-κB and Caspase-3 Activity: TLR4 Pre-activation in the Signaling Pathway of LPS-Induced Neuroprotection , 2021, Molecular Neurobiology.

[11]  S. Ng,et al.  Selecting Endpoints for Disease-Modification Trials in Inflammatory Bowel Disease: the SPIRIT consensus from the IOIBD. , 2021, Gastroenterology.

[12]  B. Nielsen,et al.  MicroRNA Biomarkers in IBD—Differential Diagnosis and Prediction of Colitis-Associated Cancer , 2020, International journal of molecular sciences.

[13]  G. Wahbeh,et al.  Ulcerative Colitis: Making the Diagnosis. , 2020, Gastroenterology clinics of North America.

[14]  Yazhou Lin,et al.  Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury , 2020, Cell Death & Disease.

[15]  M. Zeng,et al.  The anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer , 2020, Journal of Molecular Medicine.

[16]  R. Fischer,et al.  The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation , 2020, Cell Metabolism.

[17]  A. Zorzano,et al.  Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity. , 2020, Cell reports.

[18]  Shi Feng,et al.  Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4 , 2020, Genes & diseases.

[19]  G. Dubyak,et al.  Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. , 2020, The Journal of clinical investigation.

[20]  Bowen Zhou,et al.  Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. , 2020, Immunity.

[21]  Wei-Jie Lv,et al.  Shen-Ling-Bai-Zhu-San Improves Dextran Sodium Sulfate-Induced Colitis by Inhibiting Caspase-1/Caspase-11-Mediated Pyroptosis , 2020, Frontiers in Pharmacology.

[22]  S. Vermeire,et al.  Etrolizumab for the Treatment of Ulcerative Colitis and Crohn’s Disease: An Overview of the Phase 3 Clinical Program , 2020, Advances in Therapy.

[23]  G. Dubyak,et al.  N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis , 2020, Nature Communications.

[24]  P. von der Weid,et al.  Lipopolysaccharides modulate intestinal epithelial permeability and inflammation in a species-specific manner , 2020, Gut microbes.

[25]  K. Lassen,et al.  Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation , 2020, Science Advances.

[26]  D. M. Simons,et al.  Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages , 2020, Nature metabolism.

[27]  Zilin Li,et al.  Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis , 2020, Cell.

[28]  T. Billiar,et al.  Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury , 2020, Hepatology (Baltimore, Md.).

[29]  E. Quigley,et al.  The microbiome and inflammatory bowel disease. , 2020, The Journal of allergy and clinical immunology.

[30]  Chunchun Wang,et al.  Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway. , 2019, Free radical biology & medicine.

[31]  Q. Guan.  A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease , 2019, Journal of immunology research.

[32]  K. Tao,et al.  Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling. , 2019, Free radical biology & medicine.

[33]  Yu-hong Yuan,et al.  NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-κB signaling , 2019, Cell Death & Disease.

[34]  W. Liang,et al.  Saponins regulate intestinal inflammation in colon cancer and IBD. , 2019, Pharmacological research.

[35]  N. Ashley,et al.  Colonic epithelial cell diversity in health and inflammatory bowel disease , 2019, Nature.

[36]  Darren J. Fitzpatrick,et al.  Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2 , 2018, Proceedings of the National Academy of Sciences.

[37]  Edward T Chouchani,et al.  Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 , 2018, Nature.

[38]  B. Kuster,et al.  The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity , 2017, Cell reports.

[39]  K. Maloy,et al.  Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation , 2017, Front. Immunol..

[40]  K. Park,et al.  Fermented herbal formula KIOM-MA-128 protects against acute colitis induced by dextran sodium sulfate in mice , 2017, BMC Complementary and Alternative Medicine.

[41]  Wenqing Gao,et al.  Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin , 2017, Nature.

[42]  Maxim N. Artyomov,et al.  Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. , 2016, Cell metabolism.

[43]  Jun Sun,et al.  Exploring gut microbes in human health and disease: Pushing the envelope , 2014, Genes & diseases.

[44]  J. Tschopp,et al.  Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome , 2010, Gut.

[45]  R. Chapman,et al.  Effect of oral dioctyl sodium sulfosuccinate on intake-output studies of human small and large intestine. , 1985, Gastroenterology.

[46]  V. L. da Silva,et al.  Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation , 2019, Free radical biology & medicine.

[47]  E. Szigethy,et al.  Inflammatory bowel disease. , 2011, Pediatric clinics of North America.

[48]  A. Maldonado-Contreras,et al.  Intestinal epithelial cells and their role in innate mucosal immunity , 2010, Cell and Tissue Research.

[49]  G PLACITELLI,et al.  [Ulcerative colitis]. , 1958, La Riforma medica.