Do indoor chemicals promote development of airway allergy?

UNLABELLED Allergic asthma has increased worldwide in the industrialized countries. This review evaluates whether the major groups of indoor chemical exposures possess allergy-promoting (adjuvant) effects; formaldehyde was excluded, because of the size of the literature. Volatile organic compounds (VOCs) are used as an example of gases and vapors. The precipitation of asthmatic symptoms by VOC exposures is probably because of VOC levels considerably above typical indoor levels, or VOCs may be a surrogate for exposure to allergens, combustion products or dampness. Indoor particles possessed adjuvant effects in animal studies and allergy-promoting effects in humans. Quaternary ammonium compounds may possess adjuvant effects in animal studies and promoted sensitization in humans in occupational settings. The use of cleaning agents, anionic and non-ionic surfactants are not considered to possess an important adjuvant effect in the general population. Regarding phthalate exposures, results from animal and epidemiological studies were found to be discordant. There is little evidence that the indoor chemicals evaluated possess important adjuvant effects. If buildings are kept clean, dry and free of combustion products, the important question may be would it be profitable to look for lifestyle factors and non-chemical indoor exposures in order to abate airway allergy? PRACTICAL IMPLICATIONS Indoor chemicals (pollutants) have been accused to promote development of airway allergy by adjuvant effects. In this review, we evaluated the scientific literature and found little support for the supposition that indoor chemicals possess important adjuvant effects. This rises the question: would it be profitable for abatement of airway allergy to look for non-chemical indoor exposures, including lifestyle factors, and exposures to allergens, microorganisms, including vira, and their interactions?

[1]  R. de Marco,et al.  Influence of early life exposures on incidence and remission of asthma throughout life. , 2004, The Journal of allergy and clinical immunology.

[2]  J. Madsen,et al.  Residential exposure to plasticizers and its possible role in the pathogenesis of asthma. , 1997, Environmental health perspectives.

[3]  Martin Braniš,et al.  Fine Particles (PM1) in Four Different Indoor Environments , 2002, Indoor and Built Environment.

[4]  J. Golding,et al.  Frequent use of chemical household products is associated with persistent wheezing in pre-school age children , 2004, Thorax.

[5]  T Schneider,et al.  Risk in cleaning: chemical and physical exposure. , 1998, The Science of the total environment.

[6]  D. Hendrick,et al.  Asthmagenic properties of a newly developed detergent ingredient: sodium iso-nonanoyl oxybenzene sulphonate. , 1990, British journal of industrial medicine.

[7]  Peder Wolkoff,et al.  Linear alkylbenzene sulfonates in indoor floor dust. , 2002, The Science of the total environment.

[8]  B. Granum,et al.  The effect of particles on allergic immune responses. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[9]  S. Lewis,et al.  Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children , 2003, Thorax.

[10]  Cynthia Howard-Reed,et al.  Source strengths of ultrafine and fine particles due to cooking with a gas stove. , 2004, Environmental science & technology.

[11]  Per Axel Clausen,et al.  Application of the Field and Laboratory Emission Cell “FLEC” ‐ Performance Study, Intercomparison Study, and Case Study of Damaged Linoleum in an Office , 1995 .

[12]  W. Cain,et al.  Odor and chemesthesis from brief exposures to TXIB. , 2005, Indoor air.

[13]  L. Davis,et al.  Cleaning Products and Work-Related Asthma , 2003, Journal of occupational and environmental medicine.

[14]  D Norbäck,et al.  Asthma and the indoor environment: the significance of emission of formaldehyde and volatile organic compounds from newly painted indoor surfaces , 1996, International archives of occupational and environmental health.

[15]  T. Platts-Mills,et al.  Asthma and indoor air: contrasts in the dose response to cat and dust-mite. , 2005, Indoor air.

[16]  Curtis W Jarand,et al.  Diisocyanate emission from a paint product: a preliminary analysis. , 2002, Applied occupational and environmental hygiene.

[17]  C. Bornehag,et al.  Quantitative determination of volatile organic compounds in indoor dust using gas chromatography-UV spectrometry. , 2005, Environment international.

[18]  Thomas Schneider,et al.  An Intervention Study of the Effect of Improved Cleaning Methods on the Concentration and Composition of Dust , 1998 .

[19]  Andy H Lee,et al.  Household hygiene practices in relation to dampness at home and current wheezing and rhino‐conjunctivitis among school age children , 2005, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[20]  Pertti Pasanen,et al.  Critical aspects on the significance of microbial volatile metabolites as indoor air pollutants , 1998 .

[21]  Povl Ole Fanger,et al.  European Indoor Air Quality Audit Project in 56 Office Buildings , 1996 .

[22]  D. Brugge,et al.  Comparison of multiple environmental factors for asthmatic children in public housing. , 2003, Indoor air.

[23]  P. Nafstad,et al.  Interior surface materials in the home and the development of bronchial obstruction in young children in Oslo, Norway. , 1999, American journal of public health.

[24]  M. Kogevinas,et al.  Asthma, chronic bronchitis, and exposure to irritant agents in occupational domestic cleaning: a nested case-control study , 2005, Occupational and Environmental Medicine.

[25]  H. Snippe,et al.  DDA as an immunological adjuvant. , 1992, Research in immunology.

[26]  S. Barnhart,et al.  The Respiratory Effects of Volatile Organic Compounds , 2000, International journal of occupational and environmental health.

[27]  Andrea R Ferro,et al.  Elevated personal exposure to particulate matter from human activities in a residence , 2004, Journal of Exposure Analysis and Environmental Epidemiology.

[28]  Peder Wolkoff.  Volatile Organic Compounds Sources, Measurements, Emissions, and the Impact on Indoor Air Quality , 1995 .

[29]  O. Poulsen,et al.  Investigation of the adjuvant and immuno-suppressive effects of benzyl butyl phthalate, phthalic acid and benzyl alcohol in a murine injection model. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[30]  H Rüden,et al.  Occurrence of phthalates and musk fragrances in indoor air and dust from apartments and kindergartens in Berlin (Germany). , 2004, Indoor air.

[31]  P. Horn,et al.  Specific IgE and IgG1 responses to subtilisin Carlsberg (Alcalase) in mice: development of an intratracheal exposure model. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[32]  Peder Wolkoff,et al.  Gas chromatographic analysis of free fatty acids and fatty acid salts extracted with neutral and acidified dichloromethane from office floor dust , 1998 .

[33]  C. Weschler.  Indoor/outdoor connections exemplified by processes that depend on an organic compound's saturation vapor pressure , 2003 .

[34]  K. Kurppa,et al.  Excess incidence of asthma among Finnish cleaners employed in different industries , 2002, European Respiratory Journal.

[35]  H. Kay.  Environmental Health Criteria , 1980 .

[36]  D Norbäck,et al.  Asthmatic symptoms and volatile organic compounds, formaldehyde, and carbon dioxide in dwellings. , 1995, Occupational and environmental medicine.

[37]  P. Thygesen,et al.  Di-(2-ethylhexyl) phthalate possesses an adjuvant effect in a subcutaneous injection model with BALB/c mice. , 2001, Toxicology letters.

[38]  S. Bonini,et al.  Dampness in buildings as a risk factor for health effects, EUROEXPO: a multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. , 2004, Indoor air.

[39]  W. Pierson,et al.  Potential adverse health effects of wood smoke. , 1989, The Western journal of medicine.

[40]  B. Brunekreef,et al.  Early Respiratory Infections, Asthma, and Allergy: 10-Year Follow-up of the Oslo Birth Cohort , 2005, Pediatrics.

[41]  P. Lioy,et al.  Health Effects of a Mixture of Indoor Air Volatile Organics, Their Ozone Oxidation Products, and Stress , 2005, Environmental health perspectives.

[42]  K. L. Carlsen,et al.  The environment and childhood asthma (ECA) study in Oslo: ECA-1 and ECA-2. , 2002 .

[43]  H. Folgering,et al.  Health-based selection for asthma, but not for chronic bronchitis, in pig farmers: an evidence-based hypothesis. , 1999, The European respiratory journal.

[44]  Peder Wolkoff,et al.  Chemical and Biological Evaluation of Building Material Emissions. II. Approaches for Setting Indoor Air Standards or Guidelines for Chemicals , 1997 .

[45]  O. Poulsen,et al.  Adjuvant effect of quaternary ammonium compounds in a murine model. , 2004, Toxicology letters.

[46]  R. Delfino,et al.  Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. , 2001, Environmental health perspectives.

[47]  N. Petrovsky,et al.  Vaccine adjuvants: Current state and future trends , 2004, Immunology and cell biology.

[48]  K. Leong,et al.  Understanding the pathogenesis of allergic asthma using mouse models. , 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[49]  M. Kogevinas,et al.  Asthma characteristics in cleaning workers, workers in other risk jobs and office workers , 2002, European Respiratory Journal.

[50]  William W. Nazaroff,et al.  Cleaning products and air fresheners: exposure to primary and secondary air pollutants , 2004 .

[51]  C. Mccusker.  Use of mouse models of allergic rhinitis to study the upper and lower airway link , 2004, Current opinion in allergy and clinical immunology.

[52]  P. Horn,et al.  Specific antibody responses to subtilisin Carlsberg (Alcalase) in mice: development of an intranasal exposure model. , 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[53]  J. Jaakkola,et al.  Plastic wall materials in the home and respiratory health in young children. , 2000, American journal of public health.

[54]  M G Apte,et al.  Indoor air quality, ventilation and health symptoms in schools: an analysis of existing information. , 2003, Indoor air.

[55]  H. Folgering,et al.  Longitudinal changes in bronchial responsiveness associated with swine confinement dust exposure. , 2000, Chest.

[56]  Roy M Harrison,et al.  Key pollutants--airborne particles. , 2004, The Science of the total environment.

[57]  P Wolkoff,et al.  Chemical and biological evaluation of a reaction mixture of R-(+)-limonene/ozone: formation of strong airway irritants. , 2001, Environment international.

[58]  L. Mølhave,et al.  Assessment of Exposures and Health Risks Related to Formaldehyde Emissions from Furniture: a Case Study , 1995 .

[59]  J. Hongslo,et al.  Environmental chemicals relevant for respiratory hypersensitivity: the indoor environment. , 1996, Toxicology letters.

[60]  M. Flyvholm.  Preservatives in registered chemical products , 2005, Contact dermatitis.

[61]  J. Bonnefoy,et al.  DDA adjuvant induces a mixed Th1/Th2 immune response when associated with BBG2Na, a respiratory syncytial virus potential vaccine. , 2002, Vaccine.

[62]  O. Poulsen,et al.  Study of adjuvant effect of model surfactants from the groups of alkyl sulfates, alkylbenzene sulfonates, alcohol ethoxylates and soaps. , 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[63]  A. Tuomainen,et al.  Indoor air quality and health problems associated with damp floor coverings , 2004, International archives of occupational and environmental health.

[64]  Thomas J. Kelly,et al.  Emission Rates of Formaldehyde from Materials and Consumer Products Found in California Homes , 1999 .

[65]  E. C. Beuvery,et al.  Synergistic effect of detergents and aluminium phosphate on the humoral immune response to bacterial and viral membrane proteins. , 1987, Vaccine.

[66]  K. Tadokoro,et al.  Enhancing effect of suspended particulate matter on the IgE antibody production in mice. , 1989, International archives of allergy and applied immunology.

[67]  Wout Slob,et al.  Probabilistic risk characterization: an example with di(2-ethylhexyl) phthalate. , 2005, Regulatory toxicology and pharmacology : RTP.

[68]  A. Seaton,et al.  Diet as a risk factor for atopy and asthma. , 2005, The Journal of allergy and clinical immunology.

[69]  K. Takagi,et al.  Species differences in the metabolism of di(2-ethylhexyl) phthalate (DEHP) in several organs of mice, rats, and marmosets , 2005, Archives of Toxicology.

[70]  X. Baur,et al.  Occupational airway sensitizers: an overview on the respective literature. , 2000, American journal of industrial medicine.

[71]  P. Cullinan,et al.  Stepwise health surveillance for bronchial irritability syndrome in workers at risk of occupational respiratory disease. , 1998, Occupational and environmental medicine.

[72]  P. Lioy,et al.  Nasal Effects of a Mixture of Volatile Organic Compounds and Their Ozone Oxidation Products , 2005, Journal of occupational and environmental medicine.

[73]  M. Kogevinas,et al.  Asthma symptoms in women employed in domestic cleaning: a community based study , 2003, Thorax.

[74]  A. Gamer,et al.  Di-(2-ethylhexyl) phthalate: a short-term repeated inhalation toxicity study including fertility assessment. , 1992, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[75]  G. Rossi,et al.  The wheezy infant -- immunological and molecular considerations. , 2004, Paediatric respiratory reviews.

[76]  Sidney C. Soderholm,et al.  Proposal for Converting “Total” Dust Limits to Inhalable and Thoracic Dust Limits , 1993 .

[77]  M. Kopferschmitt‐Kubler,et al.  Quaternary ammonium compounds and occupational asthma , 2000, International archives of occupational and environmental health.

[78]  P. Gaarder,et al.  Quantification and characterisation of suspended particulate matter in indoor air. , 1997, The Science of the total environment.

[79]  M. Løvik,et al.  Airborne house dust elicits a local lymph node reaction and has an adjuvant effect on specific IgE production in the mouse. , 1998, Toxicology.

[80]  B. Lundbäck,et al.  Epidemiology of rhinitis and asthma. , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[81]  M. Bulsara,et al.  Association of domestic exposure to volatile organic compounds with asthma in young children , 2004, Thorax.

[82]  P. Koutrakis,et al.  Characterization of Indoor Particle Sources Using Continuous Mass and Size Monitors , 2000, Journal of the Air & Waste Management Association.

[83]  A. Togias.  Rhinitis and asthma: evidence for respiratory system integration. , 2003, The Journal of allergy and clinical immunology.

[84]  M Svartengren,et al.  Building characteristics, indoor air quality and recurrent wheezing in very young children (BAMSE). , 2004, Indoor air.

[85]  C J Weschler,et al.  Ozone in indoor environments: concentration and chemistry. , 2000, Indoor air.

[86]  R. Vermeulen,et al.  Disinfectant use as a risk factor for atopic sensitization and symptoms consistent with asthma: an epidemiological study. , 1996, The European respiratory journal.

[87]  S. Walter,et al.  Calculation of attributable risks from epidemiological data. , 1978, International journal of epidemiology.

[88]  Erik Uhde,et al.  Organic indoor air pollutants , 1999 .

[89]  Kirk R. Smith,et al.  Indoor air pollution: a global health concern. , 2003, British medical bulletin.

[90]  R. Dahl,et al.  Lung function and bronchial reactivity in asthmatics during exposure to volatile organic compounds. , 1991, The American review of respiratory disease.

[91]  E. Ford.  Current reviews of allergy and clinical immunology , 2005 .

[92]  Thomas S. Calzavara,et al.  Air sampling methodology for asphalt fume in asphalt production and asphalt roofing manufacturing facilities: total particulate sampler versus inhalable particulate sampler. , 2003, Applied occupational and environmental hygiene.

[93]  R. Lynch.  Modeling of exposure to carpet-cleaning chemicals preceding irritant-induced asthma in one patient. , 2000, Environmental health perspectives.

[94]  M. Kogevinas,et al.  Asthma risk, cleaning activities and use of specific cleaning products among Spanish indoor cleaners. , 2001, Scandinavian journal of work, environment & health.

[95]  R. G. Lewis,et al.  Distribution of pesticides and polycyclic aromatic hydrocarbons in house dust as a function of particle size. , 1999, Environmental health perspectives.

[96]  O. Poulsen,et al.  Adjuvant effect of benzalkonium chloride on the allergen-specific IgE, IgG1 and IgG2a antibody formation in BALB/cJ mice. , 2004, Basic & clinical pharmacology & toxicology.

[97]  K. Golka,et al.  An integrative approach considering acute symptoms and intensity ratings of chemosensory sensations during experimental exposures. , 2005, Environmental toxicology and pharmacology.

[98]  L. Hersoug,et al.  Viruses as the causative agent related to 'dampness' and the missing link between allergen exposure and onset of allergic disease. , 2005, Indoor air.

[99]  C. Krone.  Diisocyanates and Nonoccupational Disease: A Review , 2003, Archives of environmental health.

[100]  Ormstad,et al.  Airborne house dust particles and diesel exhaust particles as allergen carriers , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[101]  M. Kopferschmitt‐Kubler,et al.  Reported incidence of occupational asthma in France, 1996–99: the ONAP programme , 2003, Occupational and environmental medicine.

[102]  Peder Wolkoff,et al.  Indoor VOCs From Household Floor Dust: Comparison of Headspace with Desorbed VOCs; Method for VOC Release Determination , 1994 .

[103]  Charles J. Weschler,et al.  Phthalates in Indoor Dust and Their Association with Building Characteristics , 2005, Environmental health perspectives.

[104]  G. Nielsen,et al.  Detergents in the indoor environment - what is the evidence for an allergy promoting effect? Known and postulated mechanisms. , 2000, Toxicology.

[105]  L. Trupin,et al.  Impact of the Home Indoor Environment on Adult Asthma and Rhinitis , 2005, Journal of occupational and environmental medicine.

[106]  O. Poulsen,et al.  IgE-mediated asthma and rhinitis I: a role of allergen exposure? , 2002, Pharmacology & toxicology.

[107]  Andrea R Ferro,et al.  Source strengths for indoor human activities that resuspend particulate matter. , 2004, Environmental science & technology.

[108]  G. Gritti,et al.  Severe asthma and ARDS triggered by acute short-term exposure to commonly used cleaning detergents. , 2000, The European respiratory journal.

[109]  L. Morawska,et al.  Contribution from indoor sources to particle number and mass concentrations in residential houses , 2004 .

[110]  P Wolkoff,et al.  Organic compounds in office environments - sensory irritation, odor, measurements and the role of reactive chemistry. , 2006, Indoor air.

[111]  G. Nielsen.  Mechanisms of activation of the sensory irritant receptor by airborne chemicals. , 1991, Critical reviews in toxicology.

[112]  Clifford P Weisel,et al.  Assessing exposure to air toxics relative to asthma. , 2002, Environmental health perspectives.

[113]  A. Linneberg,et al.  Differential effects of risk factors on infant wheeze and atopic dermatitis emphasize a different etiology. , 2006, The Journal of allergy and clinical immunology.

[114]  Charles J. Weschler,et al.  The Association between Asthma and Allergic Symptoms in Children and Phthalates in House Dust: A Nested Case–Control Study , 2004, Environmental health perspectives.

[115]  L. Wallace,et al.  Major sources of benzene exposure. , 1989, Environmental health perspectives.

[116]  Maria Yazdanbakhsh,et al.  Allergy, parasites, and the hygiene hypothesis. , 2002, Science.

[117]  L. Jansson,et al.  Contact allergy to Tween 80 in an inhalation suspension , 2002, Contact dermatitis.

[118]  H. Folgering,et al.  Bronchial hyperresponsiveness and exposure in pig farmers , 1997, International archives of occupational and environmental health.

[119]  C. Rand,et al.  Indoor exposures to air pollutants and allergens in the homes of asthmatic children in inner-city Baltimore. , 2005, Environmental research.

[120]  A T Hodgson,et al.  Volatile organic compound concentrations and emission rates in new manufactured and site-built houses. , 2000, Indoor air.

[121]  Peder Wolkoff,et al.  Chemical and Biological Evaluation of Building Material Emissions , 1997 .

[122]  N. Wilson.  Virus infections, wheeze and asthma , 2003, Paediatric Respiratory Reviews.

[123]  L. Poulsen,et al.  Development of sensitisation or tolerance following repeated OVA inhalation in BALB/cJ mice. Dose-dependency and modulation by the Al(OH)3 adjuvant. , 2003, Toxicology.

[124]  Tunga Salthammer,et al.  Effects of Climatic Parameters on Formaldehyde Concentrations in Indoor Air , 1995 .

[125]  H. Ormstad,et al.  Suspended particulate matter in indoor air: adjuvants and allergen carriers. , 2000, Toxicology.

[126]  F. Kauffmann,et al.  Occupational exposures and asthma in 14,000 adults from the general population. , 2004, American journal of epidemiology.

[127]  D. Norbäck,et al.  Airway symptoms among house painters in relation to exposure to volatile organic compounds (VOCS)--a longitudinal study. , 1997, The Annals of occupational hygiene.

[128]  A. Jones,et al.  Asthma and the Home Environment , 2000, The Journal of asthma : official journal of the Association for the Care of Asthma.

[129]  T. Guo,et al.  Phthalate treatment does not influence levels of IgE or Th2 cytokines in B6C3F1 mice. , 2004, Toxicology.

[130]  K. Deckardt,et al.  Subchronic inhalation toxicity study of 2-ethylhexanol vapour in rats. , 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[131]  Thomas Lumley,et al.  Pulmonary Effects of Indoor- and Outdoor-Generated Particles in Children with Asthma , 2005, Environmental health perspectives.

[132]  R. Zeiger,et al.  The role of breast-feeding in the development of allergies and asthma. , 2005, The Journal of allergy and clinical immunology.

[133]  L. Poulsen,et al.  IgE-mediated sensitisation, rhinitis and asthma from occupational exposures. Smoking as a model for airborne adjuvants? , 2005, Toxicology.

[134]  R. Delfino,et al.  Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air , 2003, Journal of Exposure Analysis and Environmental Epidemiology.

[135]  B. Granum,et al.  Fine particles of widely different composition have an adjuvant effect on the production of allergen-specific antibodies. , 2001, Toxicology letters.

[136]  R. Dales,et al.  Residential Exposure to Volatile Organic Compounds and Asthma , 2004, The Journal of asthma : official journal of the Association for the Care of Asthma.

[137]  Gina Solomon,et al.  Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. , 2002, Environmental health perspectives.

[138]  T. Putus,et al.  Chemical and Microbial Exposures in a School Building: Adverse Health Effects in Children , 2004, Archives of environmental health.

[139]  J Sundell,et al.  Association between ventilation rates in 390 Swedish homes and allergic symptoms in children. , 2005, Indoor air.

[140]  L. Landau,et al.  Parental smoking: asthma and wheezing illnesses in infants and children. , 2001, Paediatric respiratory reviews.

[141]  S. Brown.  Occurrence of Volatile Organic Compounds in Indoor Air , 2007 .

[142]  T. Schneider,et al.  Dust build-up on surfaces in the indoor environment , 1999 .

[143]  O. Poulsen,et al.  Adjuvant and immuno-suppressive effect of six monophthalates in a subcutaneous injection model with BALB/c mice. , 2001, Toxicology.

[144]  D. Basketter,et al.  Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation. , 1993, Toxicology.

[145]  P. Lioy,et al.  Dust: a metric for use in residential and building exposure assessment and source characterization. , 2002, Environmental health perspectives.

[146]  S. Tortolero,et al.  Occupational exposures associated with work-related asthma and work-related wheezing among U.S. workers. , 2003, American journal of industrial medicine.

[147]  T Schneider,et al.  'EUROPART'. Airborne particles in the indoor environment. A European interdisciplinary review of scientific evidence on associations between exposure to particles in buildings and health effects. , 2003, Indoor air.