Mitochondrial pharmacology.
暂无分享,去创建一个
H. M. Cochemé | Robin A. J. Smith | R. Hartley | M. Murphy | Robin A J Smith | Michael P Murphy | Helena M Cochemé | Helena M. Cochemé | Richard C Hartley | M. Murphy
[1] M. Duchen,et al. Roles of mitochondria in human disease. , 2010, Essays in biochemistry.
[2] I. Tucker,et al. Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ 10 ), a mitochondria-targeted antioxidant, in rat , 2010 .
[3] Eva Pebay-Peyroula,et al. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside , 2003, Nature.
[4] A. Garnier,et al. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. , 2008, Cardiovascular research.
[5] L. MacMillan-Crow,et al. The Mitochondria-Targeted Antioxidant Mitoquinone Protects against Cold Storage Injury of Renal Tubular Cells and Rat Kidneys , 2011, Journal of Pharmacology and Experimental Therapeutics.
[6] J. Joseph,et al. Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide. , 2005, Free radical biology & medicine.
[7] Robin A. J. Smith,et al. Mitochondria-targeted small molecule therapeutics and probes. , 2011, Antioxidants & redox signaling.
[8] R. Youle,et al. Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. , 2011, Antioxidants & redox signaling.
[9] M. Murphy,et al. Mitochondria--a neglected drug target. , 2009, Current opinion in investigational drugs.
[10] T. Tomizaki,et al. The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å , 1996, Science.
[11] L. A. Obukhova,et al. An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.
[12] I. Nonaka,et al. A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies , 1990, Nature.
[13] Rouslan G. Efremov,et al. The architecture of respiratory complex I , 2010, Nature.
[14] D. Harrison,et al. Therapeutic targeting of mitochondrial superoxide in hypertension , 2010, Circulation research.
[15] B. Hohenester. A therapy for myopathy caused by collagen VI mutations? , 2007, Matrix biology : journal of the International Society for Matrix Biology.
[16] M. Brand,et al. Mitochondrial uncoupling as a target for drug development for the treatment of obesity , 2001, Obesity reviews : an official journal of the International Association for the Study of Obesity.
[17] Manuela G. López,et al. Mitochondrial Na+/Ca2+-Exchanger Blocker CGP37157 Protects against Chromaffin Cell Death Elicited by Veratridine , 2009, Journal of Pharmacology and Experimental Therapeutics.
[18] D. Green,et al. Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging , 2011, Science.
[19] E. Elmér,et al. The Nonimmunosuppressive Cyclosporin Analogs NIM811 and UNIL025 Display Nanomolar Potencies on Permeability Transition in Brain-Derived Mitochondria , 2004, Journal of bioenergetics and biomembranes.
[20] L. Guarente,et al. A therapeutic role for sirtuins in diseases of aging? , 2007, Trends in biochemical sciences.
[21] H. Szeto,et al. Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development , 2011, Pharmaceutical Research.
[22] Robin A. J. Smith,et al. The mitochondria‐targeted anti‐oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients , 2010, Liver international : official journal of the International Association for the Study of the Liver.
[23] B. Teicher,et al. Efficacy of Pt(Rh-123)2 as a radiosensitizer with fractionated X rays. , 1987, International journal of radiation oncology, biology, physics.
[24] A. Munnich,et al. Effect of idebenone on cardiomyopathy in Friedreich's ataxia: a preliminary study , 1999, The Lancet.
[25] H. Jacobs,et al. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction , 2010, Proceedings of the National Academy of Sciences.
[26] D. Wallace,et al. Mitochondrial energetics and therapeutics. , 2010, Annual review of pathology.
[27] H. Ke,et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases , 2012, Cell.
[28] P. Bernardi,et al. Therapy of collagen VI-related myopathies (Bethlem and Ullrich) , 2008, Neurotherapeutics.
[29] D. Rubinsztein,et al. Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. , 2010, Free radical biology & medicine.
[30] C. Mammucari,et al. Molecules and roles of mitochondrial calcium signaling. , 2011, BioFactors.
[31] R. Moreno-Sánchez,et al. Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II* , 2010, The Journal of Biological Chemistry.
[32] R. Bersin,et al. Dichloroacetate as metabolic therapy for myocardial ischemia and failure. , 1997, American heart journal.
[33] J. Eisenbart,et al. Mitochondrial complex III ROS regulate adipocyte differentiation. , 2011, Cell metabolism.
[34] S. Girardin,et al. Mitochondria in innate immunity , 2011, EMBO reports.
[35] Sang-Bing Ong,et al. Inhibiting Mitochondrial Fission Protects the Heart Against Ischemia/Reperfusion Injury , 2010, Circulation.
[36] S. Kelley,et al. Maximizing the therapeutic window of an antimicrobial drug by imparting mitochondrial sequestration in human cells. , 2011, Journal of the American Chemical Society.
[37] M. Brand,et al. CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS , 1987, Biological reviews of the Cambridge Philosophical Society.
[38] M. Crompton,et al. Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation , 2009, The Biochemical journal.
[39] A. Halestrap,et al. A pore way to die , 2005 .
[40] Robin A. J. Smith,et al. Animal and human studies with the mitochondria‐targeted antioxidant MitoQ , 2010, Annals of the New York Academy of Sciences.
[41] D. Rideout,et al. A self-assembling protein kinase C inhibitor. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[42] Pengfei Wang,et al. Mitochondria-targeting properties and photodynamic activities of porphyrin derivatives bearing cationic pendant. , 2010, Journal of photochemistry and photobiology. B, Biology.
[43] Amy V. Lynch,et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes , 2007, Nature.
[44] R. Rosenfeld. Nature , 2009, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.
[45] Michael P. Murphy,et al. How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.
[46] S. Kelley,et al. Targeting Mitochondria with Organelle‐Specific Compounds: Strategies and Applications , 2009, Chembiochem : a European journal of chemical biology.
[47] Michael Erb,et al. NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels , 2011, PloS one.
[48] E. Schon,et al. In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis , 2011, Cell metabolism.
[49] Paolo Bernardi,et al. Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis. , 2011, Cell calcium.
[50] J. Vissing,et al. 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy , 2007, Journal of Neurology.
[51] Linda Partridge,et al. Unraveling the biological roles of reactive oxygen species. , 2011, Cell metabolism.
[52] S. Kalivendi,et al. Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. , 2010, Free radical biology & medicine.
[53] P. Bonaldo,et al. Autosomal recessive myosclerosis myopathy is a collagen VI disorder , 2008, Neurology.
[54] Edward T Chouchani,et al. A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury , 2009, Proceedings of the National Academy of Sciences.
[55] M. Brand,et al. Mitochondrial uncouplers with an extraordinary dynamic range. , 2007, The Biochemical journal.
[56] A. Schapira,et al. Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects , 2000, The Lancet.
[57] T. Kuwana,et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. , 2008, Developmental cell.
[58] Rutger O. Vogel,et al. Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. , 2009, American journal of human genetics.
[59] S. Kelley,et al. Mitochondria‐Penetrating Peptides: Sequence Effects and Model Cargo Transport , 2009, Chembiochem : a European journal of chemical biology.
[60] P. Chinnery,et al. The inheritance of pathogenic mitochondrial DNA mutations , 2009, Biochimica et biophysica acta.
[61] B. Chance,et al. 31P NMR study of improvement in oxidative phosphorylation by vitamins K3 and C in a patient with a defect in electron transport at complex III in skeletal muscle. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[62] Robin A. J. Smith,et al. Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.
[63] D. Menon,et al. Rapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: implications for mitochondria-specific therapies and probes. , 2010, Biochimica et biophysica acta.
[64] V. Mootha,et al. The mitochondrial proteome and human disease. , 2010, Annual review of genomics and human genetics.
[65] T. A. Link,et al. Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. , 1998, Science.
[66] L. Gluud,et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. , 2012, The Cochrane database of systematic reviews.
[67] Z. Rao,et al. Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II , 2005, Cell.
[68] M. Ryan,et al. Assembly factors of human mitochondrial complex I and their defects in disease , 2010, IUBMB life.
[69] R. Hartley,et al. Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore , 2011, Journal of the American Chemical Society.
[70] D. Bers,et al. Mitochondria: from basic biology to cardiovascular disease. , 2009, Journal of molecular and cellular cardiology.
[71] H. Atamna,et al. Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase. , 2010, Journal of Alzheimer's disease : JAD.
[72] L. Partridge,et al. Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix , 2011, Cell metabolism.
[73] M. Ristow,et al. Small‐Molecule Targeting of the Mitochondrial Compartment with an Endogenously Cleaved Reversible Tag , 2009, Chembiochem : a European journal of chemical biology.
[74] S. Rodríguez-Enríquez,et al. Selective degradation of mitochondria by mitophagy. , 2007, Archives of biochemistry and biophysics.
[75] B. Spiegelman,et al. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. , 2008, Cell metabolism.
[76] M. Zeviani,et al. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. , 2009, Cell metabolism.
[77] N. Jhala,et al. Mitochondria‐targeted ubiquinone (MitoQ) decreases ethanol‐dependent micro and macro hepatosteatosis , 2011, Hepatology.
[78] L. Galluzzi,et al. Targeting mitochondria for cancer therapy , 2010, Nature Reviews Drug Discovery.
[79] J. Franklin,et al. The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease , 2011, The Journal of Neuroscience.
[80] E. Murphy,et al. What makes the mitochondria a killer? Can we condition them to be less destructive? , 2011, Biochimica et biophysica acta.
[81] Gene Kim,et al. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. , 2009, The Journal of clinical investigation.
[82] G. Feher,et al. Crystallization and X-ray structure determination of cytochrome c2 from Rhodobacter sphaeroides in three crystal forms. , 1995, Acta crystallographica. Section D, Biological crystallography.
[83] R. Lightowlers,et al. Progress and prospects: gene therapy for mitochondrial DNA disease , 2008, Gene Therapy.
[84] Robin A. J. Smith,et al. Synthesis and Characterization of a Triphenylphosphonium-conjugated Peroxidase Mimetic , 2005, Journal of Biological Chemistry.
[85] C. Angelini,et al. Mitochondrial disorders of the nuclear genome. , 2009, Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology.
[86] R. Tompkins,et al. Novel Mitochondria-Targeted Antioxidant Peptide Ameliorates Burn-Induced Apoptosis and Endoplasmic Reticulum Stress in the Skeletal Muscle of Mice , 2011, Shock.
[87] V. Skulachev,et al. Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore , 2009, Proceedings of the National Academy of Sciences.
[88] P. Chinnery,et al. Mitochondrial myopathies: developments in treatment. , 2010, Current opinion in neurology.
[89] N. Neamati,et al. Preclinical Evaluation of Novel Triphenylphosphonium Salts with Broad-Spectrum Activity , 2010, PloS one.
[90] S. Dimauro,et al. The genetics and pathology of oxidative phosphorylation , 2001, Nature Reviews Genetics.
[91] A. Leslie,et al. On the structure of the stator of the mitochondrial ATP synthase , 2006, The EMBO journal.
[92] C. Reggiani,et al. Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency , 2003, Nature Genetics.
[93] J. Auwerx,et al. Regulation of PGC-1 a , a nodal regulator of mitochondrial biogenesis 1 – 4 , 2011 .
[94] A. Ferlini,et al. Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies , 2008, Proceedings of the National Academy of Sciences.
[95] Edward T Chouchani,et al. Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation , 2010, The Biochemical journal.
[96] Shuang Liu,et al. 64Cu-labeled phosphonium cations as PET radiotracers for tumor imaging. , 2011, Bioconjugate chemistry.
[97] Pierre Croisille,et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. , 2008, The New England journal of medicine.