Initial Experience with Tricortical Iliac Crest Bone Graft and Human Amniotic Allograft in Evans Calcaneal Osteotomy

Background: Adult acquired flatfoot deformity is generally mediated with an Evans procedure where a wedge of bone is placed into the calcaneus to better align the foot and decrease the deformity. The purpose of this study was to assess the efficacy and safety of human amniotic allograft applied to allogeneic tri-cortical grafts in Evans calcaneal osteotomy. Methods: The medical records of patients who had Evans calcaneal osteotomy with implantation of tri-cortical iliac crest bone graft with human anmiotic allograft for surgical management of adult acquired flatfoot deformity with 2 years follow-up data were reviewed. Results: A total of 63 patients (mean age: 33.3 yr, range: 18 - 66 yr) were enrolled with adult acquired flatfoot deformity. Median time to weight-bearing was 6 weeks. Time to wearing normal shoes was 10 weeks, and time to radiographic healing was 16 weeks. Conclusions: The use of human amniotic allograft did not diminish the long term outcome of procedure or the short term benchmarks for healing after surgery. There were no nonunion, wound dehiscence, infection, or allergic or immune reaction reported. This retrospective study demonstrated that tri-cortical iliac crest bone graft and HAA could be safely used in Evans calcaneal osteotomy with favorable results.

[1]  J. Boone,et al.  Ankle arthrodesis fusion rates for mesenchymal stem cell bone allograft versus proximal tibia autograft. , 2014, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[2]  Myron Hansen,et al.  Human Amniotic Allograft in Use on Talar Dome Lesions: A Prospective Report of 37 Patients , 2014 .

[3]  Nathan S Jeppesen,et al.  First Metatarsophalangeal Joint Arthrodesis: Comparison of Mesenchymal Stem Cell Allograft versus Autogenous Bone Graft Fusion Rates , 2013 .

[4]  Y. Murayama,et al.  Human amnion-derived cells as a reliable source of stem cells. , 2012, Current molecular medicine.

[5]  J. Moraleda,et al.  The amniotic membrane as a source of stem cells. , 2010, Histology and histopathology.

[6]  Bircan Sönmez,et al.  Effects of human amniotic fluid on fracture healing in rat tibia. , 2009, The Journal of surgical research.

[7]  D. Mooney,et al.  Biologic augmentation of polymer scaffolds for bone repair. , 2007, Journal of musculoskeletal & neuronal interactions.

[8]  J. Sainthillier,et al.  Use of amniotic membrane transplantation in the treatment of venous leg ulcers , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[9]  N. Breslow Clinical Trials—I , 2006 .

[10]  S. Strom,et al.  Amnion-derived pluripotent/multipotent stem cells , 2006, Stem Cell Reviews.

[11]  P. Koşucu,et al.  Effect of human amniotic fluid on bone healing. , 2005, The Journal of surgical research.

[12]  G. Weinraub Orthobiologics: a survey of materials and techniques. , 2005, Clinics in podiatric medicine and surgery.

[13]  S. Gupta,et al.  A trial to determine the role of placental extract in the treatment of chronic non-healing wounds. , 2004, Journal of wound care.

[14]  M. Mitchell,et al.  Critical Paracrine Interactions Between TNF-α and IL-10 Regulate Lipopolysaccharide-Stimulated Human Choriodecidual Cytokine and Prostaglandin E2 Production1 , 2003, The Journal of Immunology.

[15]  S. Parikh Bone graft substitutes: past, present, future. , 2002, Journal of postgraduate medicine.

[16]  B. MacWilliams,et al.  Plantar Pressure and Radiographic Changes After Distal Calcaneal Lengthening in Children and Adolescents , 2001, Journal of pediatric orthopedics.

[17]  C. Cornell,et al.  Osteoconductive materials and their role as substitutes for autogenous bone grafts. , 1999, The Orthopedic clinics of North America.

[18]  M. Bostrom,et al.  Bone grafting and new composite biosynthetic graft materials. , 1998, Instructional course lectures.

[19]  N. Sharkey,et al.  Bone ingrowth and mechanical properties of coralline hydroxyapatite 1 yr after implantation. , 1993, Biomaterials.

[20]  J. Fabré,et al.  The healing of chronic venous leg ulcers with prepared human amnion. , 1989, British journal of plastic surgery.

[21]  D. Green,et al.  Planal dominance. , 1984, Journal of the American Podiatry Association.

[22]  M. Scheflan,et al.  Clinical trials of amniotic membranes in burn wound care. , 1982, Plastic and reconstructive surgery.

[23]  S. Leibowitz,et al.  IMMUNOGENICITY OF HUMAN AMNIOTIC EPITHELIAL CELLS AFTER TRANSPLANTATION INTO VOLUNTEERS , 1981, The Lancet.

[24]  W.Page Faulk,et al.  HUMAN AMNION AS AN ADJUNCT IN WOUND HEALING , 1980, The Lancet.

[25]  J. Trelford,et al.  The amnion in surgery, past and present. , 1979, American journal of obstetrics and gynecology.

[26]  J. Needham,et al.  Medieval Preparations of Urinary Steroid Hormones , 1963, Nature.

[27]  J. Pigeon Treatment of second-degree burns with amniotic membranes. , 1960, Canadian Medical Association journal.

[28]  D. Evans Recurrent Instability of the Ankle—a Method of Surgical Treatment , 1953, Proceedings of the Royal Society of Medicine.

[29]  F. Cole Placental blood and placental extract in wound healing. , 1948, American journal of surgery.

[30]  M. Shimberg THE USE OF AMNIOTIC-FLUID CONCENTRATE IN ORTHOPAEDIC CONDITIONS , 1938 .