Genotoxicity: damage to DNA and its consequences.

[1]  Paolo Vineis,et al.  Molecular Epidemiology of Chronic Diseases , 2008 .

[2]  Gunnar Brunborg,et al.  The comet assay: topical issues. , 2008, Mutagenesis.

[3]  Awadhesh N Jha,et al.  Ecotoxicological applications and significance of the comet assay. , 2008, Mutagenesis.

[4]  D. Phillips.  Biomarkers of Exposure: Adducts , 2008 .

[5]  Raffaella Corvi,et al.  ECVAM retrospective validation of in vitro micronucleus test (MNT) , 2008, Mutagenesis.

[6]  Graham M Lord,et al.  Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer. , 2009, Carcinogenesis.

[7]  M. Schiffman,et al.  Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: an immunohistochemistry study. , 2007, Mutation research.

[8]  V. Arlt,et al.  The 32P-postlabeling assay for DNA adducts , 2007, Nature Protocols.

[9]  B. Jelaković,et al.  Aristolochic acid and the etiology of endemic (Balkan) nephropathy , 2007, Proceedings of the National Academy of Sciences.

[10]  K. Turteltaub,et al.  Tamoxifen forms DNA adducts in human colon after administration of a single [14C]-labeled therapeutic dose. , 2007, Cancer research.

[11]  M. Olivier,et al.  Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database , 2007, Human mutation.

[12]  Julie Clements,et al.  Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment. , 2007, Mutation research.

[13]  P. Carmichael,et al.  Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive. , 2006, Mutagenesis.

[14]  J. Doehmer.  Predicting Drug Metabolism–dependent Toxicity for Humans with a Genetically Engineered Cell Battery , 2006, Alternatives to laboratory animals : ATLA.

[15]  P Boffetta,et al.  Chromosomal aberrations and SCEs as biomarkers of cancer risk. , 2006, Mutation research.

[16]  M. Fenech.  Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. , 2006, Mutation research.

[17]  M. Kirsch‐Volders,et al.  The in vitro micronucleus test: from past to future. , 2006, Mutation research.

[18]  H. Sugimura,et al.  Development of the adductome approach to detect DNA damage in humans. , 2006, Antioxidants & redox signaling.

[19]  M. Cimino,et al.  Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes , 2006, Environmental and molecular mutagenesis.

[20]  K. Mortelmans,et al.  Isolation of plasmid pKM101 in the Stocker laboratory. , 2006, Mutation research.

[21]  Catherine C. Smith,et al.  hOGG1 recognizes oxidative damage using the comet assay with greater specificity than FPG or ENDOIII. , 2006, Mutagenesis.

[22]  Steffen Loft,et al.  Bulky DNA adducts as risk indicator of lung cancer in a Danish case‐cohort study , 2006, International journal of cancer.

[23]  P. Farmer,et al.  Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection. , 2006, Carcinogenesis.

[24]  G. Pfeifer,et al.  Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. , 2005, Carcinogenesis.

[25]  P. Olive,et al.  The comet assay: a method to measure DNA damage in individual cells , 2006, Nature Protocols.

[26]  I. Lambert,et al.  Detailed review of transgenic rodent mutation assays. , 2005, Mutation research.

[27]  P B Farmer,et al.  DNA adducts: mass spectrometry methods and future prospects. , 2005, Toxicology and applied pharmacology.

[28]  Paolo Vineis,et al.  DNA adducts and lung cancer risk: a prospective study. , 2005, Cancer research.

[29]  A. Luch.  The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons , 2005 .

[30]  D. Oscier,et al.  Capillary electrophoresis‐laser induced fluorescence analysis of endogenous damage in mitochondrial and genomic DNA , 2005, Electrophoresis.

[31]  Tetsuo Satoh,et al.  Salmonella/human S9 mutagenicity test: a collaborative study with 58 compounds. , 2005, Mutagenesis.

[32]  D. Phillips.  Macromolecular adducts as biomarkers of human exposure to polycyclic aromatic hydrocarbons. , 2005 .

[33]  G. Speit,et al.  The comet assay: a sensitive genotoxicity test for the detection of DNA damage. , 2005, Methods in molecular biology.

[34]  H. Glatt,et al.  Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects. , 2005, Methods in enzymology.

[35]  M. Kirsch‐Volders,et al.  Human population studies with cytogenetic biomarkers: Review of the literature and future prospectives , 2005, Environmental and molecular mutagenesis.

[36]  K. Brown,et al.  Techniques: the application of accelerator mass spectrometry to pharmacology and toxicology. , 2004, Trends in pharmacological sciences.

[37]  Danielle L. Watt,et al.  Polycyclic aromatic hydrocarbon-DNA adducts determined by semiquantitative immunohistochemistry in human esophageal biopsies taken in 1985. , 2004, Mutation research.

[38]  A. Martelli,et al.  Failure of the standard battery of short-term tests in detecting some rodent and human genotoxic carcinogens. , 2004, Toxicology.

[39]  A. Collins,et al.  The comet assay for DNA damage and repair , 2004, Molecular biotechnology.

[40]  P. Armitage,et al.  The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis , 1954, British Journal of Cancer.

[41]  Takayoshi Suzuki,et al.  In vivo transgenic mutation assays. , 2003, Mutation research.

[42]  ESCODD,et al.  Measurement of DNA oxidation in human cells by chromatographic and enzymic methods , 2003 .

[43]  Maria Dusinska,et al.  Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. , 2003, Free radical biology & medicine.

[44]  H. Döhner,et al.  Capillary electrophoretic analysis of genomic DNA methylation levels. , 2003, Nucleic acids research.

[45]  J. T. Macgregor,et al.  Summary of major conclusions. , 1994, Mutation research.

[46]  R. Sinha,et al.  Highly sensitive chemiluminescence immunoassay for benzo[a]pyrene-DNA adducts: validation by comparison with other methods, and use in human biomonitoring. , 2002, Carcinogenesis.

[47]  P. Albert,et al.  Semiquantitation of polycyclic aromatic hydrocarbon-DNA adducts in human esophagus by immunohistochemistry and the automated cellular imaging system. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[48]  D. Phillips.  Smoking-related DNA and protein adducts in human tissues. , 2002, Carcinogenesis.

[49]  V. Arlt,et al.  Is aristolochic acid a risk factor for Balkan endemic nephropathy‐associated urothelial cancer? , 2002, International journal of cancer.

[50]  Micheline Kirsch-Volders,et al.  Importance of detecting numerical versus structural chromosome aberrations. , 2002, Mutation research.

[51]  V. Arlt,et al.  Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. , 2002, Mutagenesis.

[52]  O. Schmitz,et al.  Capillary electrophoresis analysis of DNA adducts as biomarkers for carcinogenesis. , 2002, Angewandte Chemie.

[53]  F P Perera,et al.  Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study. , 2001, Cancer research.

[54]  J. Clements.  The mouse lymphoma assay. , 2000, Mutation research.

[55]  T. Nohmi,et al.  Recent advances in the protocols of transgenic mouse mutation assays. , 2000, Mutation research.

[56]  E. Zeiger,et al.  The Ames Salmonella/microsome mutagenicity assay. , 2000, Mutation research.

[57]  L. Knudsen,et al.  The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[58]  M D Waters,et al.  IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans. International Programme on Chemical Safety. , 2000, Mutation research.

[59]  F. Perera.  Molecular epidemiology: on the path to prevention? , 2000, Journal of the National Cancer Institute.

[60]  R. Santella,et al.  Carcinogen macromolecular adducts and their measurement. , 2000, Carcinogenesis.

[61]  L. Marnett,et al.  Oxyradicals and DNA damage. , 2000, Carcinogenesis.

[62]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[63]  K. Turteltaub,et al.  Methods of Dna Adduct Determination and Their Application to Testing Compounds for Genotoxicity , 2022 .

[64]  J. T. Macgregor,et al.  In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring , 2000, Environmental and Molecular Mutagenesis.

[65]  R. Tice,et al.  Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing , 2000, Environmental and molecular mutagenesis.

[66]  D. B. McGregor,et al.  The use of short-and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation. Consensus report. , 1999, IARC scientific publications.

[67]  R. Santella.  Immunological methods for detection of carcinogen-DNA damage in humans. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[68]  D. Phillips,et al.  Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients. , 1999, Cancer research.

[69]  K. Turteltaub,et al.  DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[70]  D. Phillips,et al.  Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. , 1999, Mutagenesis.

[71]  H. van Steeg,et al.  Use of DNA Repair-Deficient XPA Transgenic Mice in Short-Term Carcinogenicity Testing , 1998, Toxicologic pathology.

[72]  D. Phillips.  Detection of DNA modifications by the 32P-postlabelling assay. , 1997, Mutation research.

[73]  M. Yamada,et al.  Targeted disruption of the gene encoding the classical nitroreductase enzyme in Salmonella typhimurium Ames test strains TA1535 and TA1538. , 1997, Mutation research.

[74]  M. Tang,et al.  Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.

[75]  J. French,et al.  Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[76]  J. Haines,et al.  International programme on chemical safety , 1996, The Lancet.

[77]  D. Phillips.  DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke. , 1996, Environmental health perspectives.

[78]  O. Ueda,et al.  Other transgenic mutation assays: A new transgenic mouse mutagenesis test system using Spi− and 6‐thioguanine selections , 1996, Environmental and molecular mutagenesis.

[79]  R R Tice,et al.  In vivo rodent erythrocyte micronucleus assay. , 1994, Mutation research.

[80]  M. Poirier,et al.  Human exposure monitoring, dosimetry, and cancer risk assessment: the use of antisera specific for carcinogen-DNA adducts and carcinogen-modified DNA. , 1994, Drug metabolism reviews.

[81]  B. Henderson,et al.  A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[82]  N. Dumaz,et al.  Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[83]  A. Weston.  Physical methods for the detection of carcinogen-DNA adducts in humans. , 1993, Mutation research.

[84]  J. Lewtas,et al.  DNA adducts as biomarkers for assessing exposure to polycyclic aromatic hydrocarbons in tissues from Xuan Wei women with high exposure to coal combustion emissions and high lung cancer mortality. , 1993, Environmental health perspectives.

[85]  A. C. Beach,et al.  Human biomonitoring and the 32P-postlabeling assay. , 1992, Carcinogenesis.

[86]  D L Putman,et al.  Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[87]  M. Ishidate,et al.  Mutagenicity of 30 chemicals in Salmonella typhimurium strains possessing different nitroreductase or O-acetyltransferase activities. , 1991, Mutation research.

[88]  D Pinkel,et al.  Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome-specific DNA probes. , 1990, Mutation research.

[89]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[90]  M. Kirsch‐Volders,et al.  An improved method for the 'in vitro' micronucleus test using human lymphocytes. , 1990, Mutagenesis.

[91]  J Vijg,et al.  Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[92]  R. Tice,et al.  A simple technique for quantitation of low levels of DNA damage in individual cells. , 1988, Experimental cell research.

[93]  J. Ashby,et al.  Evaluation of short-term tests for carcinogens , 1988 .

[94]  S. Venitt,et al.  Mutagenicity Testing: a Practical Approach , 1986, British Journal of Cancer.

[95]  R. Gupta,et al.  Enhanced sensitivity of 32P-postlabeling analysis of aromatic carcinogen:DNA adducts. , 1985, Cancer research.

[96]  D. Clive,et al.  Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/- mouse lymphoma cells. , 1985, Mutation research.

[97]  M. Fenech,et al.  Measurement of micronuclei in lymphocytes. , 1985, Mutation research.

[98]  C. Marshall,et al.  Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide , 1984, Nature.

[99]  B. Ames,et al.  Revised methods for the Salmonella mutagenicity test. , 1983, Mutation research.

[100]  R. Gupta,et al.  32P-postlabeling analysis of non-radioactive aromatic carcinogen--DNA adducts. , 1982, Carcinogenesis.

[101]  R. Gupta,et al.  32P-labeling test for DNA damage. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[102]  K. Randerath.  ^ P-postlabeling test for DNA damage , 1981 .

[103]  W. W. Nichols,et al.  Short-term tests for carcinogens and mutagens. , 1979, Mutation research.

[104]  D. Clive,et al.  Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system. , 1979, Mutation research.

[105]  B. Ames,et al.  Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[106]  D. Clive,et al.  A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. , 1972, Mutation research.

[107]  EINZ,et al.  UROTHELIAL CARCINOMA ASSOCIATED WITH THE USE OF A CHINESE HERB ( ARISTOLOCHIA FANGCHI ) , 2022 .