The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

[1]  E. Jansen,et al.  High-dose dexamethasone accentuates nuclear factor-kappa b activation in endotoxin-treated mice. , 2001, American journal of respiratory and critical care medicine.

[2]  T. Hawn,et al.  Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity , 2007, Circulation research.

[3]  T. Maniatis,et al.  Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. , 2007, Science.

[4]  R. Gaynor,et al.  The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. , 1998, Nature.

[5]  S. O’Rahilly,et al.  PPARγ and human metabolic disease , 2006 .

[6]  K. Wellen,et al.  Inflammation, stress, and diabetes. , 2005, The Journal of clinical investigation.

[7]  M. Karin,et al.  JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. , 2007, Cell metabolism.

[8]  G. Hotamisligil,et al.  Inflammation and metabolic disorders , 2006, Nature.

[9]  M. Kojima,et al.  Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet. , 2007, American journal of physiology. Endocrinology and metabolism.

[10]  J. Olefsky,et al.  Insulin sensitivity: modulation by nutrients and inflammation. , 2008, The Journal of clinical investigation.

[11]  Kohjiro Ueki,et al.  Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. , 2006, The Journal of clinical investigation.

[12]  J. Carvalheira,et al.  Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance , 2007, Diabetes.

[13]  W. Fiers,et al.  Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis. , 1992, Endocrinology.

[14]  K. Umesono,et al.  Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. , 1998, The Journal of clinical investigation.

[15]  D. Moller.  Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes , 2000, Trends in Endocrinology & Metabolism.

[16]  Hui Chen,et al.  FOXO1 Represses Peroxisome Proliferator-activated Receptor-γ1 and -γ2 Gene Promoters in Primary Adipocytes , 2006, Journal of Biological Chemistry.

[17]  M. Karin,et al.  Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity , 2008, Cell.

[18]  M. Scadeng,et al.  Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance , 2007, Nature Medicine.

[19]  A. Saltiel,et al.  Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity , 2007, Diabetes.

[20]  M. Kanzaki,et al.  Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. , 1999, Molecular cell.

[21]  S. Shoelson,et al.  Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. , 2005, Nature medicine.

[22]  T. Kadowaki,et al.  Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. , 2005, Diabetes.

[23]  Ruxana T. Sadikot,et al.  High-Dose Dexamethasone Accentuates Nuclear Factor- κ B Activation in Endotoxin-Treated Mice , 2001 .

[24]  Michael Q. Zhang,et al.  Interferon regulatory factors are transcriptional regulators of adipogenesis. , 2008, Cell metabolism.

[25]  AC Tose.  Cell , 1993, Cell.

[26]  R. Kitazawa,et al.  MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. , 2006, The Journal of clinical investigation.

[27]  J. Girard,et al.  Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. , 2008, The Journal of clinical investigation.

[28]  A. Marette,et al.  Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. , 2005, Endocrinology.

[29]  H. Kaneto,et al.  Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status* , 2004, Journal of Biological Chemistry.

[30]  A. Klip,et al.  Tissue-specific roles of IRS proteins in insulin signaling and glucose transport , 2006, Trends in Endocrinology & Metabolism.

[31]  Hui Chen,et al.  FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity. , 2006, The Journal of biological chemistry.

[32]  R. Leibel,et al.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding. , 2006, The Journal of clinical investigation.

[33]  M. Saad,et al.  Lipin Deficiency Impairs Diurnal Metabolic Fuel Switching , 2006, Diabetes.

[34]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[35]  C. Kahn,et al.  Critical nodes in signalling pathways: insights into insulin action , 2006, Nature Reviews Molecular Cell Biology.

[36]  R. Gaynor,et al.  The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β , 1998, Nature.

[37]  T. Harris,et al.  Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[38]  Takashi Kadowaki,et al.  Combination , 2019, Understanding the Law of Assignment.

[39]  T. Luedde,et al.  Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis , 2008, Proceedings of the National Academy of Sciences.

[40]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[41]  A. Saltiel,et al.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.

[42]  A. Saltiel.  New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes , 2001, Cell.

[43]  D. Moller.  Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. , 2000, Trends in endocrinology and metabolism: TEM.

[44]  Laura Herrero,et al.  Obesity, inflammation, and insulin resistance. , 2007, Gastroenterology.

[45]  S. O’Rahilly,et al.  PPAR gamma and human metabolic disease. , 2006, The Journal of clinical investigation.

[46]  Jong-Seok Moon,et al.  Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. , 2008 .

[47]  H. Tilg,et al.  Inflammatory Mechanisms in the Regulation of Insulin Resistance , 2008, Molecular medicine.

[48]  David A. Brenner,et al.  Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways , 2006 .

[49]  Jianping Ye,et al.  Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. , 2007, American journal of physiology. Endocrinology and metabolism.

[50]  M. Bradbury.  Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[51]  R. Schwabe,et al.  Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[52]  D. Moller,et al.  Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. , 1998, Endocrinology.

[53]  A. Hevener,et al.  IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.

[54]  A. Saltiel,et al.  Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes , 2008, Diabetes.

[55]  A. Brasier,et al.  Tumor necrosis factor increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase. , 1994, Endocrinology.

[56]  T. Maniatis,et al.  Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity , 2007, Science.

[57]  S. Shoelson,et al.  Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB , 2005, Nature Medicine.

[58]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[59]  M. Czaja,et al.  Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance , 2009, Hepatology.

[60]  A. Sanyal.  Mechanisms of Disease: pathogenesis of nonalcoholic fatty liver disease , 2005, Nature Clinical Practice Gastroenterology &Hepatology.

[61]  Y. Deshaies,et al.  PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. , 2003, Diabetes.

[62]  Margaret S. Wu,et al.  Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression. , 1998, Endocrinology.

[63]  Y. Loh,et al.  Faculty Opinions recommendation of Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. , 2008 .

[64]  J. Hirsch,et al.  Adipose tissue cellularity in human obesity. , 1976, Clinics in endocrinology and metabolism.

[65]  J. H. Johnson,et al.  Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. , 1998, Proceedings of the National Academy of Sciences of the United States of America.