Percutaneous radiofrequency ablation of colorectal cancer liver Metastases: Factors Affecting Outcomes—A 10-year Experience at a Single Center 1

Materials and Methods: This study consisted of a HIPAA-compliant institutional review board–approved retrospective review of data in 162 patients with 233 CLMs treated with percutaneous RFA between December 2002 and December 2012. Contrast material–enhanced CT was used to assess technique effectiveness 4–8 weeks after RFA. Patients were followed up with contrast-enhanced CT every 2–4 months. Overall survival (OS) and local tumor progression–free survival (LTPFS) were calculated from the time of RFA by using the Kaplan-Meier method. Log-rank tests and Cox regression models were used for univariate and multivariate analysis to identify predictors of outcomes.

[1]  T. de Baère,et al.  Percutaneous radiofrequency thermoablation as an alternative to surgery for treatment of liver tumour recurrence after hepatectomy , 2002, The British journal of surgery.

[2]  David Sacks,et al.  Quality improvement guidelines for percutaneous transhepatic cholangiography and biliary drainage. Society of Cardiovascular and Interventional Radiology. , 1997, Journal of vascular and interventional radiology : JVIR.

[3]  Yuman Fong,et al.  American Society of Clinical Oncology 2009 clinical evidence review on radiofrequency ablation of hepatic metastases from colorectal cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  S Nahum Goldberg,et al.  Image-guided tumor ablation: standardization of terminology and reporting criteria. , 2005, Radiology.

[5]  J. Berlin,et al.  Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.

[6]  C. V. van Kuijk,et al.  Long-term results of radiofrequency ablation for unresectable colorectal liver metastases: a potentially curative intervention. , 2011, The British journal of radiology.

[7]  K. Takeda,et al.  Radiofrequency ablation for colorectal liver metastases: prognostic factors in non-surgical candidates , 2012, Japanese Journal of Radiology.

[8]  E. Van Cutsem,et al.  Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. , 2009, The New England journal of medicine.

[9]  S. Nehmeh,et al.  Split-dose technique for FDG PET/CT-guided percutaneous ablation: a method to facilitate lesion targeting and to provide immediate assessment of treatment effectiveness. , 2013, Radiology.

[10]  W. Silen,et al.  Natural history of liver metastases from colorectal carcinoma , 1997, Journal of Gastrointestinal Surgery.

[11]  T. Ruers,et al.  Treatment of liver metastases, an update on the possibilities and results. , 2002, European journal of cancer.

[12]  D. Dupuy,et al.  Radiofrequency ablation of colorectal hepatic metastases , 2010, Journal of surgical oncology.

[13]  W. Lees,et al.  Five-year survival in 309 patients with colorectal liver metastases treated with radiofrequency ablation , 2009, European Radiology.

[14]  Yuman Fong,et al.  Actual 10-year survival after resection of colorectal liver metastases defines cure. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  R. van Hillegersberg,et al.  Viable Tumor Tissue Adherent to Needle Applicators after Local Ablation: A Risk Factor for Local Tumor Progression , 2011, Annals of Surgical Oncology.

[16]  S. Solomon,et al.  Treatment of pulmonary colorectal metastases by radiofrequency ablation. , 2013, Clinical colorectal cancer.

[17]  T. Vogl,et al.  Image-guided tumor ablation: standardization of terminology and reporting criteria--a 10-year update. , 2014, Journal of vascular and interventional radiology : JVIR.

[18]  M. Gonen,et al.  CT-guided radiofrequency ablation as a salvage treatment of colorectal cancer hepatic metastases developing after hepatectomy. , 2011, Journal of vascular and interventional radiology : JVIR.

[19]  L. Schwartz,et al.  Ki-67 is a Prognostic Biomarker of Survival after Radiofrequency Ablation of Liver Malignancies , 2012, Annals of Surgical Oncology.

[20]  Kenneth Hess,et al.  Recurrence and Outcomes Following Hepatic Resection, Radiofrequency Ablation, and Combined Resection/Ablation for Colorectal Liver Metastases , 2004, Annals of surgery.

[21]  S Bengmark,et al.  The natural history of primary and secondary malignant tumors of the liver I. The prognosis for patients with hepatic metastases from colonic and rectal carcinoma by laparotomy , 1969, Cancer.

[22]  Karen T. Brown,et al.  Margin Size is an Independent Predictor of Local Tumor Progression After Ablation of Colon Cancer Liver Metastases , 2013, CardioVascular and Interventional Radiology.

[23]  B. Nordlinger,et al.  Surgical resection of colorectal carcinoma metastases to the liver: A prognostic scoring system to improve case selection, based on 1568 patients , 1996, Cancer.

[24]  L H Blumgart,et al.  Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. , 1999, Annals of surgery.

[25]  C. Sofocleous,et al.  Imaging to optimize liver tumor ablation. , 2010, Imaging in medicine.

[26]  L. Schwartz,et al.  Histopathologic and immunohistochemical features of tissue adherent to multitined electrodes after RF ablation of liver malignancies can help predict local tumor progression: initial results. , 2008, Radiology.

[27]  K. Klein,et al.  Histopathologic evaluation of tissue extracted on the radiofrequency probe after ablation of liver tumors: preliminary findings. , 2004, AJR. American journal of roentgenology.

[28]  M. Choti,et al.  Liver Resection for Colorectal Metastases in Presence of Extrahepatic Disease: Results from an International Multi-institutional Analysis , 2011, Annals of Surgical Oncology.

[29]  M. Choti,et al.  Metastatic colon cancer, version 3.2013: featured updates to the NCCN Guidelines. , 2013, Journal of the National Comprehensive Cancer Network : JNCCN.

[30]  Luigi Solbiati,et al.  Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. , 2003, Radiology.

[31]  Luigi Solbiati,et al.  Small liver colorectal metastases treated with percutaneous radiofrequency ablation: local response rate and long-term survival with up to 10-year follow-up. , 2012, Radiology.