GABA predicts visual intelligence

Highlights • Cortical GABA levels correlate with visuo-spatial IQ and surround suppression.• Higher levels predict higher intelligence and stronger surround suppression.• Results provide mechanism linking surround suppression and intelligence.• Results suggest role of cortical GABA levels in determining cognitive performance.

[1]  H. Adesnik,et al.  A neural circuit for spatial summation in visual cortex , 2012, Nature.

[2]  D. Heeger,et al.  Measurement and modeling of center-surround suppression and enhancement , 2001, Vision Research.

[3]  J. Bizon,et al.  Molecular aspects of age-related cognitive decline: the role of GABA signaling. , 2015, Trends in molecular medicine.

[4]  J. Movshon,et al.  Time Course and Time-Distance Relationships for Surround Suppression in Macaque V1 Neurons , 2003, The Journal of Neuroscience.

[5]  R. Edden,et al.  In vivo magnetic resonance spectroscopy of GABA: a methodological review. , 2012, Progress in nuclear magnetic resonance spectroscopy.

[6]  R. Edden,et al.  Gannet: A batch‐processing tool for the quantitative analysis of gamma‐aminobutyric acid–edited MR spectroscopy spectra , 2014, Journal of magnetic resonance imaging : JMRI.

[7]  Ignacio Serrano-Pedraza,et al.  Two Common Psychophysical Measures of Surround Suppression Reflect Independent Neuronal Mechanisms Task 1: Motion-direction Discrimination Task 2: Contrast Detection Suppression Index (si) , 2022 .

[8]  Wm. R. Wright General Intelligence, Objectively Determined and Measured. , 1905 .

[9]  Helena X Wang,et al.  Responses to second-order texture modulations undergo surround suppression , 2012, Vision Research.

[10]  P. H. Arx,et al.  Correspondence Between the General Ability to Discriminate Sensory Stimuli and General Intelligence , 2010 .

[11]  Duje Tadin,et al.  A Strong Interactive Link between Sensory Discriminations and Intelligence , 2013, Current Biology.

[12]  Christopher C. Pack,et al.  Bidirectional manipulation of GABAergic inhibition in MT: A comparison of neuronal and psychophysical performance , 2014 .

[13]  Y. Schiller Activation of a calcium-activated cation current during epileptiform discharges and its possible role in sustaining seizure-like events in neocortical slices. , 2004, Journal of neurophysiology.

[14]  Evan S. Schaffer,et al.  Inhibitory Stabilization of the Cortical Network Underlies Visual Surround Suppression , 2009, Neuron.

[15]  Christopher C. Pack,et al.  A neural basis for the spatial suppression of visual motion perception , 2016, bioRxiv.

[16]  Christopher Patrick Taylor,et al.  Aging Reduces Center-Surround Antagonism in Visual Motion Processing , 2005, Neuron.

[17]  I. Deary Intelligence and auditory discrimination: Separating processing speed and fidelity of stimulus representation , 1994 .

[18]  Krish D. Singh,et al.  Orientation Discrimination Performance Is Predicted by GABA Concentration and Gamma Oscillation Frequency in Human Primary Visual Cortex , 2009, The Journal of Neuroscience.

[19]  Jong H. Yoon,et al.  GABA Concentration Is Reduced in Visual Cortex in Schizophrenia and Correlates with Orientation-Specific Surround Suppression , 2010, The Journal of Neuroscience.

[20]  Richard B. Ivry,et al.  Individual differences in GABA content are reliable but are not uniform across the human cortex , 2016, NeuroImage.

[21]  D. Tadin Suppressive mechanisms in visual motion processing: From perception to intelligence , 2015, Vision Research.

[22]  A. Bompas,et al.  More GABA, less distraction: a neurochemical predictor of motor decision speed , 2010, Nature Neuroscience.

[23]  Shu-Chen Li,et al.  From good senses to good sense: A link between tactile information processing and intelligence , 1998 .

[24]  M. Garwood,et al.  Simultaneous in vivo spectral editing and water suppression , 1998, NMR in biomedicine.

[25]  Ignacio Serrano-Pedraza,et al.  Moderate acute alcohol intoxication has minimal effect on surround suppression measured with a motion direction discrimination task. , 2015, Journal of vision.

[26]  M. Landy,et al.  Orientation-selective adaptation to first- and second-order patterns in human visual cortex. , 2006, Journal of neurophysiology.

[27]  Tomas Knapen,et al.  GABA Shapes the Dynamics of Bistable Perception , 2013, Current Biology.

[28]  Huiquan Wang,et al.  Edited magnetic resonance spectroscopy detects an age-related decline in brain GABA levels , 2013, NeuroImage.

[29]  Robert Sekuler,et al.  Attention-modulated Alpha-band Oscillations Protect against Intrusion of Irrelevant Information , 2013, Journal of Cognitive Neuroscience.