N‐Acetylcysteine Treatment Protects Against VEGF‐Receptor Blockade‐Related Emphysema

Administration of the VEGF receptor blocker SU5416 to rats causes alveolar septal cell apoptosis and emphysema; both can be prevented by a superoxide dismutase mimetic. Here we show that SU5416 induces the expression of heme oxygenase‐1 in the lung tissue and that administration of antioxidant N‐acetyl‐l‐cysteine protects alveolar septal cells against apoptosis, as demonstrated by caspase‐3 lung immunohistochemistry, and against emphysema.

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