Using CellML in Computational Models of Multiscale Physiology

A computational modeling framework is presented which enables the integration of multiple physics and spatial scales in models of physiological systems. A novel aspect of the framework is the use of CellML to specify all model and simulation specific mathematical equations including cellular models and material constitutive relationships. Models of cardiac electromechanics at cellular, tissue, and organ spatial scales are used to illustrate the developed and implemented framework and other applications are discussed

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