Photocontrol of the translocation of molecules, peptides, and quantum dots through cell and lipid membranes doped with azobenzene copolymers.

Light opens: Photocontrolled transmembrane passage of soluble dyes and delivery of small peptides into mammalian cells has been achieved using azobenzene-modified polymers (AMPs) as permeabilizing agents. Irradiation with UV and visible light triggers polarity switches upon cis-trans isomerization of the azobenzene moieties. Photoresponsive permeability and pore opening promoted by trans-AMPs, but not cis-AMPs, in supported lipid bilayers are observed.

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