Inflamed fat: what starts the fire?

Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.

[1]  R. Busse,et al.  Role of macrophage tissue infiltration in metabolic diseases , 2005, Current opinion in clinical nutrition and metabolic care.

[2]  M. Desai,et al.  Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.

[3]  S. Grundy,et al.  The metabolic syndrome , 2003, The Lancet.

[4]  S. B. Pedersen,et al.  Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. , 2005, The Journal of clinical endocrinology and metabolism.

[5]  D. Loskutoff,et al.  Monocyte chemoattractant protein 1 in obesity and insulin resistance , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[6]  R. Ransohoff,et al.  The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). , 2003, Seminars in immunology.

[7]  Yihai Cao,et al.  Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice , 2004, Circulation research.

[8]  Shupei Wang,et al.  Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Published, JLR Papers in Press, September 8, 2005. DOI 10.1194/jlr.M500294-JLR200 , 2005, Journal of Lipid Research.

[9]  R. Jain,et al.  Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis , 2003, Circulation research.

[10]  P. Scherer,et al.  Printed in U.S.A. Copyright © 2003 by The Endocrine Society doi: 10.1210/en.2003-0580 Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis , 2022 .

[11]  R. L. Richardson,et al.  Adipose tissue angiogenesis. , 2004, Journal of animal science.

[12]  Jean-Daniel Zucker,et al.  Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. , 2005, Diabetes.

[13]  B. Lowell,et al.  Adipose tissue mass can be regulated through the vasculature , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[14]  I. Charo,et al.  Chemokines in the pathogenesis of vascular disease. , 2004, Circulation research.

[15]  L. Tartaglia,et al.  Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. , 2003, The Journal of clinical investigation.

[16]  D. Loskutoff,et al.  Angiogenesis in an in vivo model of adipose tissue development , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  R. Leibel,et al.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding. , 2006, The Journal of clinical investigation.

[18]  Chunsheng Zhang,et al.  Diet induction of monocyte chemoattractant protein-1 and its impact on obesity. , 2005, Obesity research.

[19]  D. Ribatti,et al.  Analysis of the role of chemokines in angiogenesis. , 2003, Journal of immunological methods.

[20]  A. Hevener,et al.  IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.

[21]  K. Wellen,et al.  Inflammation, stress, and diabetes. , 2005, The Journal of clinical investigation.