Profiling of miRNAs and target genes related to cystogenesis in ADPKD mouse models

[1]  I. Shin,et al.  Glut1 promotes cell proliferation, migration and invasion by regulating epidermal growth factor receptor and integrin signaling in triple-negative breast cancer cells , 2017, BMB reports.

[2]  M. Hatley,et al.  MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease. , 2016, Journal of the American Society of Nephrology : JASN.

[3]  Marie E. Edwards,et al.  Mutations in GANAB, Encoding the Glucosidase IIα Subunit, Cause Autosomal-Dominant Polycystic Kidney and Liver Disease. , 2016, American journal of human genetics.

[4]  A. Boletta,et al.  Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis , 2015, Cells.

[5]  H. Dweep,et al.  miRWalk2.0: a comprehensive atlas of microRNA-target interactions , 2015, Nature Methods.

[6]  J. Bradner,et al.  Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. , 2015, Human molecular genetics.

[7]  Giuseppe Remuzzi,et al.  MicroRNAs in kidney physiology and disease , 2015, Nature Reviews Nephrology.

[8]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[9]  P. Jackson,et al.  3D spheroid model of mIMCD3 cells for studying ciliopathies and renal epithelial disorders , 2014, Nature Protocols.

[10]  Paul Theodor Pyl,et al.  HTSeq—a Python framework to work with high-throughput sequencing data , 2014, bioRxiv.

[11]  A. Takakura,et al.  Polycystin-1 regulates actin cytoskeleton organization and directional cell migration through a novel PC1-Pacsin 2-N-Wasp complex. , 2014, Human molecular genetics.

[12]  Ana Kozomara,et al.  miRBase: annotating high confidence microRNAs using deep sequencing data , 2013, Nucleic Acids Res..

[13]  Young-Joon Kim,et al.  Genome-wide methylation profiling of ADPKD identified epigenetically regulated genes associated with renal cyst development , 2014, Human Genetics.

[14]  E. Avner,et al.  Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease. , 2013, The Journal of clinical investigation.

[15]  P. Igarashi,et al.  miR-17∼92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease , 2013, Proceedings of the National Academy of Sciences.

[16]  T. Vallenius.  Actin stress fibre subtypes in mesenchymal-migrating cells , 2013, Open Biology.

[17]  Harsh Dweep,et al.  Parallel Analysis of mRNA and microRNA Microarray Profiles to Explore Functional Regulatory Patterns in Polycystic Kidney Disease: Using PKD/Mhm Rat Model , 2013, PloS one.

[18]  Cole Trapnell,et al.  TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions , 2013, Genome Biology.

[19]  P. Igarashi,et al.  MicroRNAs regulate renal tubule maturation through modulation of Pkd1. , 2012, Journal of the American Society of Nephrology : JASN.

[20]  U. Tran,et al.  Small RNAs have a big effect on polycystic kidney disease. , 2012, Journal of the American Society of Nephrology : JASN.

[21]  B. Magenheimer,et al.  Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. , 2012, Kidney international.

[22]  Jing Zhou,et al.  Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease , 2011, BMC Systems Biology.

[23]  Cole Trapnell,et al.  Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. , 2010, Nature biotechnology.

[24]  Colin N. Dewey,et al.  RNA-Seq gene expression estimation with read mapping uncertainty , 2009, Bioinform..

[25]  Mark D. Robinson,et al.  edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..

[26]  S. Somlo,et al.  ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice. , 2010, Gastroenterology.

[27]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[28]  V. Torres,et al.  Autosomal dominant polycystic kidney disease: the last 3 years. , 2009, Kidney international.

[29]  P. Pandolfi,et al.  Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1 , 2009, Molecular and Cellular Biology.

[30]  G. Germino,et al.  Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells. , 2009, Kidney international.

[31]  M. Caplan,et al.  Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. , 2008, Human molecular genetics.

[32]  B. Williams,et al.  Mapping and quantifying mammalian transcriptomes by RNA-Seq , 2008, Nature Methods.

[33]  L. Cantley,et al.  Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. , 2008, Human molecular genetics.

[34]  M. Carlier,et al.  Regulation of actin assembly associated with protrusion and adhesion in cell migration. , 2008, Physiological reviews.

[35]  N. Rajewsky,et al.  Discovering microRNAs from deep sequencing data using miRDeep , 2008, Nature Biotechnology.

[36]  J. Miyoshi,et al.  Structural and functional associations of apical junctions with cytoskeleton. , 2008, Biochimica et biophysica acta.

[37]  Alessandra Boletta,et al.  Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion. , 2007, Molecular biology of the cell.

[38]  Martijn H Breuning,et al.  Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. , 2004, Human molecular genetics.

[39]  Lin He,et al.  MicroRNAs: small RNAs with a big role in gene regulation , 2004, Nature Reviews Genetics.

[40]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[41]  M. DeRuiter,et al.  Lowering of Pkd 1 expression is sufficient to cause polycystic kidney disease , 2004 .

[42]  Sergei Egorov,et al.  Pathway studio - the analysis and navigation of molecular networks , 2003, Bioinform..

[43]  S. Nishikawa,et al.  WAVE2 is required for directed cell migration and cardiovascular development , 2003, Nature.

[44]  Hironori Katoh,et al.  RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo , 2003, Nature.

[45]  N. Brown,et al.  Integrins in development: moving on, responding to, and sticking to the extracellular matrix. , 2002, Developmental cell.

[46]  Alessandra Boletta,et al.  PKD1 Induces p21waf1 and Regulation of the Cell Cycle via Direct Activation of the JAK-STAT Signaling Pathway in a Process Requiring PKD2 , 2002, Cell.

[47]  K. Brindle,et al.  Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[48]  G. Germino,et al.  Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents , 2000, Nature.

[49]  L P Sullivan,et al.  cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway. , 2000, Kidney international.

[50]  P. Gabow,et al.  Autosomal dominant polycystic kidney disease--more than a renal disease. , 1990, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[51]  ScienceDirect.  American journal of kidney diseases : AJKD : the official journal of the National Kidney Foundation. , 1981 .

[52]  L. F. Greene,et al.  Cystic disease of the kidney. , 1968, GP.