Emerging Poly‐Agonists for Obesity and Type 2 Diabetes

Possibly as many as 2 billion adults currently have overweight or obesity, according to the World Health Organization, and obesity constitutes the most severe global health threat of our time. Dietary modifications and physical activity can promote weight loss, but adherence to these lifestyle modifications has so far proven impossible. Decades of research indicate that humans are evolutionarily wired to favor a positive energy balance and to stubbornly defend body weight gains (1).