Translational pharmacology of the mGluR 2-preferring agonist LY 2812223 in animal and human brain

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[1]  G. Marek,et al.  CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography , 2013, Neuropharmacology.

[2]  P. Kammermeier.  Functional and Pharmacological Characteristics of Metabotropic Glutamate Receptors 2/4 Heterodimers , 2012, Molecular Pharmacology.

[3]  Eric Trinquet,et al.  A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  J. Wuu,et al.  Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease , 2010, Journal of Chemical Neuroanatomy.

[5]  A. Christopoulos,et al.  Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia , 2008, Proceedings of the National Academy of Sciences.

[6]  J. Pin,et al.  Activation of a Dimeric Metabotropic Glutamate Receptor by Intersubunit Rearrangement* , 2007, Journal of Biological Chemistry.

[7]  G. Marek,et al.  Pharmacological and Pharmacokinetic Properties of a Structurally Novel, Potent, and Selective Metabotropic Glutamate 2/3 Receptor Agonist: In Vitro Characterization of Agonist (–)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic Acid (LY404039) , 2007, Journal of Pharmacology and Experimental Therapeutics.

[8]  D. Schoepp,et al.  Anxiolytic-like activity of the mGLU2/3 receptor agonist LY354740 in the elevated plus maze test is disrupted in metabotropic glutamate receptor 2 and 3 knock-out mice , 2005, Psychopharmacology.

[9]  J. Wess,et al.  M1 muscarinic receptor signaling in mouse hippocampus and cortex , 2002, Brain Research.

[10]  D. McClure,et al.  Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay. , 1999, The Journal of pharmacology and experimental therapeutics.

[11]  D. Schoepp,et al.  LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors , 1997, Neuropharmacology.

[12]  J. Rostas,et al.  A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions , 1988, Brain Research.

[13]  S. Mitchell,et al.  Recent developments in metabotropic glutamate receptors as novel drug targets , 2010, Drug News & Perspectives.