Urupocidin C: a new marine guanidine alkaloid which selectively kills prostate cancer cells via mitochondria targeting

[1]  F. Honecker,et al.  Marine Compounds and Cancer: The First Two Decades of XXI Century , 2019, Marine drugs.

[2]  H. Schlüter,et al.  Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones , 2019, Cancers.

[3]  J. Neuzil,et al.  Targeting mitochondria as an anticancer strategy , 2019, Cancer communications.

[4]  M. Farag,et al.  Marine Natural Products: A Source of Novel Anticancer Drugs , 2019, Marine drugs.

[5]  L. Shubina,et al.  Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra , 2019, Natural product research.

[6]  V. Ivanenko,et al.  Express Method for Isolation of Ready-to-Use 3D Chitin Scaffolds from Aplysina archeri (Aplysineidae: Verongiida) Demosponge , 2019, Marine drugs.

[7]  I. Faraoni,et al.  Role of BRCA Mutations in Cancer Treatment with Poly(ADP-ribose) Polymerase (PARP) Inhibitors , 2018, Cancers.

[8]  N. Nonomura,et al.  Role of Androgen Receptor in Prostate Cancer: A Review , 2018, The world journal of men's health.

[9]  Joo Young Lee,et al.  Mitochondrial-Targeting Anticancer Agent Conjugates and Nanocarrier Systems for Cancer Treatment , 2018, Front. Pharmacol..

[10]  S. Bornstein,et al.  Anti-Tumorigenic and Anti-Metastatic Activity of the Sponge-Derived Marine Drugs Aeroplysinin-1 and Isofistularin-3 against Pheochromocytoma In Vitro , 2018, Marine drugs.

[11]  S. Kaplan,et al.  The molecular biology of prostate cancer: current understanding and clinical implications , 2017, Prostate Cancer and Prostatic Diseases.

[12]  C. Bokemeyer,et al.  Synthesis and anticancer activity of the derivatives of marine compound rhizochalin in castration resistant prostate cancer , 2018, Oncotarget.

[13]  M. Hermann,et al.  Olaparib is effective in combination with, and as maintenance therapy after, first‐line endocrine therapy in prostate cancer cells , 2018, Molecular oncology.

[14]  H. Ehrlich,et al.  Marine Spongin: Naturally Prefabricated 3D Scaffold-Based Biomaterial , 2018, Marine drugs.

[15]  M. Rubin,et al.  Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study , 2018, European urology.

[16]  anonymous In Review , 2018 .

[17]  A. Bishayee,et al.  Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas , 2018, Nutrients.

[18]  Stelamar Romminger,et al.  The chemistry and biology of guanidine natural products. , 2017, Natural product reports.

[19]  J. Joseph,et al.  A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds , 2017, Redox biology.

[20]  J. Joseph,et al.  Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. , 2017, Chemical reviews.

[21]  Y. Moazami,et al.  Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids. , 2017, Bioorganic & medicinal chemistry.

[22]  C. Bokemeyer,et al.  Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells , 2017, Leukemia & lymphoma.

[23]  Yuliya V. Korolkova,et al.  Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors , 2017, Marine drugs.

[24]  Alan Ashworth,et al.  PARP inhibitors: Synthetic lethality in the clinic , 2017, Science.

[25]  C. Bokemeyer,et al.  The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells , 2017, BMC Cancer.

[26]  Ying Feng,et al.  Nomogram prediction of individual prognosis of patients with hepatocellular carcinoma , 2017, BMC Cancer.

[27]  K. Hall,et al.  Cytotoxic Guanidine Alkaloids from a French Polynesian Monanchora n. sp. Sponge. , 2016, Journal of natural products.

[28]  C. Bokemeyer,et al.  Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro , 2016, Marine drugs.

[29]  T. Zhu,et al.  Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107 , 2016, Marine drugs.

[30]  H. Malve Exploring the ocean for new drug developments: Marine pharmacology , 2016, Journal of pharmacy & bioallied sciences.

[31]  Hyung-Ryong Kim,et al.  Endoplasmic Reticulum Stress and Associated ROS , 2016, International journal of molecular sciences.

[32]  Yongkyun Kim,et al.  Single-molecule visualization of ROS-induced DNA damage in large DNA molecules. , 2016, The Analyst.

[33]  Wei Yuan,et al.  DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. , 2015, The New England journal of medicine.

[34]  M. Fini,et al.  Deep sea as a source of novel-anticancer drugs , 2015 .

[35]  W. Isaacs,et al.  AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. , 2014, The New England journal of medicine.

[36]  P. Nelson Targeting the androgen receptor in prostate cancer--a resilient foe. , 2014, The New England journal of medicine.

[37]  V. Stonik,et al.  Urupocidin A: a new, inducing iNOS expression bicyclic guanidine alkaloid from the marine sponge Monanchora pulchra. , 2014, Organic letters.

[38]  C. Bokemeyer,et al.  Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells , 2014, BioMed research international.

[39]  S. Sollott,et al.  Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. , 2014, Physiological reviews.

[40]  N. Weigel,et al.  Androgen receptors in hormone-dependent and castration-resistant prostate cancer. , 2013, Pharmacology & therapeutics.

[41]  Bradley S Moore,et al.  Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. , 2012, Chemistry & biology.

[42]  Vaibhav Saxena,et al.  Approaches for targeting mitochondria in cancer therapy. , 2011, Biochimica et biophysica acta.

[43]  R. Hill,et al.  Marine Natural Products , 2011, Topics in Heterocyclic Chemistry.

[44]  V. Stepanov,et al.  Genomes, Populations and Diseases: Ethnic Genomics and Personalized Medicine , 2010, Acta naturae.

[45]  T. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method. , 2010, Cancer research.

[46]  V. Stonik,et al.  Marine Natural Products: A Way to New Drugs , 2009, Acta naturae.

[47]  Peng Huang,et al.  Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.

[48]  Stonik Va Marine natural products: a way to new drugs , 2009 .

[49]  Robin A. J. Smith,et al.  Targeting antioxidants to mitochondria by conjugation to lipophilic cations. , 2007, Annual review of pharmacology and toxicology.

[50]  Ting-Chao Chou,et al.  Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.

[51]  C. Bewley,et al.  Crambescidin 826 and dehydrocrambine A: new polycyclic guanidine alkaloids from the marine sponge Monanchora sp. that inhibit HIV-1 fusion. , 2003, Journal of natural products.

[52]  D. Green,et al.  Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis , 2003, The Journal of cell biology.

[53]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[54]  G. Palade,et al.  The fine structure of mitochondria , 1952, The Anatomical record.

[55]  Robert A. Keyzers,et al.  Marine natural products. , 2019, Natural product reports.

[56]  M. Takaki,et al.  The chemistry and biology of guanidine natural products. , 2017, Natural product reports.

[57]  B. Mignotte,et al.  The mitochondrial pathways of apoptosis. , 2012, Advances in experimental medicine and biology.

[58]  T. Molinski,et al.  Drug development from marine natural products , 2009, Nature Reviews Drug Discovery.

[59]  Lorenzo Galluzzi,et al.  Mitochondrial membrane permeabilization in cell death. , 2007, Physiological reviews.

[60]  D. Faulkner,et al.  Marine pharmacology , 2004, Antonie van Leeuwenhoek.

[61]  D. Faulkner Marine natural products. , 2000, Natural product reports.

[62]  W. E. Thompson,et al.  Nuclear magnetic resonance spectra of amines. I. Identification of N-methyl tertiary amines. , 1966, Journal of pharmaceutical sciences.