Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice.
暂无分享,去创建一个
D. Rader | J. Witztum | M. Linton | C. Funk | S. Fazio | R. Tangirala | T. Cyrus
[1] S. L. Murphy,et al. Deaths: final data for 1996. , 1998, National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System.
[2] D. Rader,et al. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice , 1998, Nature Medicine.
[3] H. Kühn,et al. The Rabbit 15-Lipoxygenase Preferentially Oxygenates LDL Cholesterol Esters, and This Reaction Does Not Require Vitamin E* , 1998, The Journal of Biological Chemistry.
[4] R. Evans,et al. PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL , 1998, Cell.
[5] R. Evans,et al. Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ , 1998, Cell.
[6] G. FitzGerald,et al. IPF2α-I: An index of lipid peroxidation in humans , 1998 .
[7] A. Daugherty,et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit. , 1998, Atherosclerosis.
[8] R. Evans,et al. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. , 1998, Cell.
[9] P. Reaven,et al. Fibroblasts that overexpress 15-lipoxygenase generate bioactive and minimally modified LDL. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[10] G. FitzGerald,et al. Nomenclature of isoprostanes: a proposal. , 1997, Prostaglandins.
[11] S. Feinmark,et al. Is there a role for 15-lipoxygenase in atherogenesis? , 1997, Biochemical pharmacology.
[12] G. FitzGerald,et al. Localization of distinct F2-isoprostanes in human atherosclerotic lesions. , 1997, The Journal of clinical investigation.
[13] V. A. Folcik,et al. Cytokine modulation of LDL oxidation by activated human monocytes. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[14] J. Witztum,et al. The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and beta2 glycoprotein 1 (and other proteins). , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[15] Daniel Steinberg,et al. Low Density Lipoprotein Oxidation and Its Pathobiological Significance* , 1997, The Journal of Biological Chemistry.
[16] Wei Sha,et al. Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo * , 1997, The Journal of Biological Chemistry.
[17] L. Chan,et al. The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions. , 1997, Current opinion in lipidology.
[18] R. D. Dyer,et al. Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties , 1997, British journal of pharmacology.
[19] D. Heydeck,et al. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. , 1997, The Journal of clinical investigation.
[20] R. Kuban,et al. Phenylalanine 353 is a primary determinant for the positional specificity of mammalian 15-lipoxygenases. , 1996, Journal of molecular biology.
[21] J. Cornhill,et al. Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development. , 1996, The Journal of clinical investigation.
[22] C. Funk. The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice. , 1996, Biochimica et biophysica acta.
[23] C. Funk,et al. Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages , 1996, The Journal of Biological Chemistry.
[24] P. Edwards,et al. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. , 1996, Arteriosclerosis, thrombosis, and vascular biology.
[25] J. Berliner,et al. The role of oxidized lipoproteins in atherogenesis. , 1996, Free radical biology & medicine.
[26] T. Nikkari,et al. Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions. , 1995, Circulation.
[27] R. Dean,et al. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-tocopherol and ascorbate. , 1995, Arteriosclerosis, thrombosis, and vascular biology.
[28] S. Yamashita,et al. Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects. , 1995, The Journal of clinical investigation.
[29] S. Young,et al. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis. , 1995, Arteriosclerosis, thrombosis, and vascular biology.
[30] D. Steinberg,et al. Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase. , 1995, Journal of lipid research.
[31] V. A. Folcik,et al. Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques. , 1995, The Journal of clinical investigation.
[32] T. Nikkari,et al. Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein. , 1995, The Journal of clinical investigation.
[33] D. Steinberg,et al. Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase (*) , 1995, The Journal of Biological Chemistry.
[34] S. Fazio,et al. Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation , 1995, Science.
[35] J. Morrow,et al. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. , 1994, The Journal of biological chemistry.
[36] S. Yamamoto,et al. Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities. , 1994, Journal of lipid research.
[37] J. Witztum,et al. The oxidation hypothesis of atherosclerosis , 1994, The Lancet.
[38] M. D. de Bruijn,et al. Markers of mouse macrophage development detected by monoclonal antibodies. , 1994, Journal of immunological methods.
[39] S. Wohlfeil,et al. Involvement of 15-lipoxygenase in early stages of atherogenesis , 1994, The Journal of experimental medicine.
[40] N. Copeland,et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. , 1994, The Journal of biological chemistry.
[41] V. Ord,et al. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.
[42] R. Ross,et al. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.
[43] W. Glasgow,et al. Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. , 1993, European journal of biochemistry.
[44] Shozo Yamamoto,et al. Mammalian lipoxygenases: molecular structures and functions. , 1992, Biochimica et biophysica acta.
[45] N. Maeda,et al. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. , 1992, Science.
[46] E. Rubin,et al. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells , 1992, Cell.
[47] S. Ylä-Herttuala. Gene expression in atherosclerotic lesions. , 1992, Herz.
[48] H. Kuhn,et al. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[49] C. Craik,et al. A primary determinant for lipoxygenase positional specificity , 1991, Nature.
[50] C. Glass,et al. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[51] A. J. Valente,et al. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[52] J L Witztum,et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. , 1989, The Journal of clinical investigation.
[53] B. Thiele,et al. Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes. , 1989, Biochemical and biophysical research communications.
[54] J L Witztum,et al. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. , 1989, The New England journal of medicine.
[55] J L Witztum,et al. Low density lipoprotein undergoes oxidative modification in vivo. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[56] D. Steinberg,et al. A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[57] J. Steinberg. Book ReviewAmbulatory Pediatric Care , 1989 .
[58] D. Steinberg,et al. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[59] D. Steinberg,et al. Macrophage Oxidation of Low Density Lipoprotein Generates a Modified Form Recognized by the Scavenger Receptor , 1986, Arteriosclerosis.
[60] A. Chait,et al. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. , 1984, The Journal of clinical investigation.
[61] D. Morel,et al. Endothelial and Smooth Muscle Cells Alter Low Density Lipoprotein In Vitro by Free Radical Oxidation , 1984, Arteriosclerosis.
[62] J L Witztum,et al. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[63] D. Steinberg,et al. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. , 1981, Proceedings of the National Academy of Sciences of the United States of America.