The development and benefits of metformin in various diseases

[1]  Hong Shi,et al.  Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis , 2023, Signal Transduction and Targeted Therapy.

[2]  P. Mecocci,et al.  A blast from the past: To tame time with metformin , 2022, Mechanisms of Ageing and Development.

[3]  A. Havas,et al.  The role of aging in cancer , 2022, Molecular oncology.

[4]  K. Kudabayeva,et al.  Effects of metformin on lymphocyte DNA damage in obese individuals among Kazakh population. , 2022, Diabetes & metabolic syndrome.

[5]  N. Lalic,et al.  Therapeutic vs. Suprapharmacological Metformin Concentrations: Different Effects on Energy Metabolism and Mitochondrial Function in Skeletal Muscle Cells in vitro , 2022, Frontiers in Pharmacology.

[6]  A. Śliwińska,et al.  Metabolic Action of Metformin , 2022, Pharmaceuticals.

[7]  S. Masoodi,et al.  Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes , 2022, BMC Endocrine Disorders.

[8]  Yunjun Yang,et al.  Lewy Body-Associated Proteins A-Synuclein (a-syn) as a Plasma-Based Biomarker for Parkinson’s Disease , 2022, Frontiers in Aging Neuroscience.

[9]  B. Tyler,et al.  Metformin and Cancer, an Ambiguanidous Relationship , 2022, Pharmaceuticals.

[10]  Yao-yu Mei,et al.  Effects of Cisplatin Combined with Metformin on Proliferation and Apoptosis of Nasopharyngeal Carcinoma Cells , 2022, Computational and mathematical methods in medicine.

[11]  Yi Wang,et al.  Paradoxical effects of posterior intralaminar thalamic calretinin neurons on hippocampal seizure via distinct downstream circuits , 2022, iScience.

[12]  Yingbo Dai,et al.  Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling , 2022, Cancer cell international.

[13]  J. Rungby,et al.  Diabetes, antidiabetic medications and risk of depression – A population-based cohort and nested case-control study , 2022, Psychoneuroendocrinology.

[14]  I. Rubio,et al.  Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models , 2022, Biomolecules.

[15]  Y. Bao,et al.  Low-dose metformin targets the lysosomal AMPK pathway through PEN2 , 2022, Nature.

[16]  R. Seeley,et al.  The GDF15-GFRAL pathway is dispensable for the effects of metformin on energy balance , 2022, bioRxiv.

[17]  Xin-jian Lin,et al.  Metformin sensitizes AML cells to chemotherapy through blocking mitochondrial transfer from stromal cells to AML cells. , 2022, Cancer letters.

[18]  Jiandie D. Lin,et al.  Histone Deacetylase 6 Inhibition Restores Leptin Sensitivity and Reduces Obesity , 2021, Nature Metabolism.

[19]  P. Albert,et al.  Rewiring of the Serotonin System in Major Depression , 2021, Frontiers in Psychiatry.

[20]  S. Wongkham,et al.  Repurposing Metformin for Cancer Treatment: A Great Challenge of a Promising Drug , 2021, AntiCancer Research.

[21]  J. Larrick,et al.  Sensitizing tumors to anti-PD-1 therapy by promoting NK and CD8+ T cells via pharmacological activation of FOXO3 , 2021, Journal for ImmunoTherapy of Cancer.

[22]  Yong-Mei Zhang,et al.  New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism , 2021, Acta Pharmacologica Sinica.

[23]  K. Clément,et al.  Adipose Tissue Fibrosis in Obesity: Etiology and Challenges. , 2021, Annual review of physiology.

[24]  Luis E Munoz,et al.  Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy , 2021, Journal for ImmunoTherapy of Cancer.

[25]  Huafeng Zhang,et al.  Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase , 2021, Cell Death & Disease.

[26]  B. Strauss,et al.  Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells , 2021, Aging.

[27]  D. Koya,et al.  Autophagy in metabolic disease and ageing , 2021, Nature Reviews Endocrinology.

[28]  E. Calabrese,et al.  Metformin-enhances resilience via hormesis , 2021, Ageing Research Reviews.

[29]  V. Tosello,et al.  Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia , 2021, International journal of molecular sciences.

[30]  Yi Wang,et al.  Revealing the Precise Role of Calretinin Neurons in Epilepsy: We Are on the Way , 2021, Neuroscience Bulletin.

[31]  L. Zaharenko,et al.  Metformin Transport Rates Between Plasma and Red Blood Cells in Humans , 2021, Clinical Pharmacokinetics.

[32]  M. R. França,et al.  Metformin prevents p-tau and amyloid plaque deposition and memory impairment in diabetic mice , 2021, Experimental Brain Research.

[33]  I. Park,et al.  Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin , 2021, BMC cancer.

[34]  A. Sikora,et al.  Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects , 2021, Journal for ImmunoTherapy of Cancer.

[35]  L. Appel,et al.  Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial , 2021, Diabetes Care.

[36]  I. Moussa,et al.  Lucrative antioxidant effect of metformin against cyclophosphamide induced nephrotoxicity , 2021, Saudi journal of biological sciences.

[37]  T. Ulutin,et al.  Anti-cancer effect of metformin on the metastasis and invasion of primary breast cancer cells through mediating NF-kB activity. , 2021, Acta histochemica.

[38]  Haidi Yang,et al.  Metformin Alleviates Cisplatin-Induced Ototoxicity by Autophagy Induction Possibly via the AMPK/FOXO3a Pathway. , 2021, Journal of neurophysiology.

[39]  Minjia Tan,et al.  AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ. , 2021, Cell reports.

[40]  C. Yen,et al.  Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation , 2021, Frontiers in Cell and Developmental Biology.

[41]  D. Skondra,et al.  Association of Metformin Use With Age-Related Macular Degeneration: A Case-Control Study. , 2021, JAMA ophthalmology.

[42]  Sahithi Attaluri,et al.  Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus , 2021, Aging cell.

[43]  M. Likeman,et al.  The metformin in tuberous sclerosis (MiTS) study: A randomised double-blind placebo-controlled trial , 2021, EClinicalMedicine.

[44]  Fei Liu,et al.  Tau in Alzheimer’s Disease: Pathological Alterations and an Attractive Therapeutic Target , 2020, Current Medical Science.

[45]  Y. Hsiao,et al.  Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells , 2020, Molecular medicine reports.

[46]  Shilei Zhang,et al.  Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways , 2020, Molecular therapy oncolytics.

[47]  E. Engleman,et al.  Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance. , 2020, Annual review of pathology.

[48]  N. Calcutt,et al.  Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system , 2020, Expert review of neurotherapeutics.

[49]  D. Bennett,et al.  The Relation of Diabetes to Memory Function , 2020, Current Neurology and Neuroscience Reports.

[50]  O. Werz,et al.  Loss of metabolic plasticity underlies metformin toxicity in aged Caenorhabditis elegans , 2020, Nature Metabolism.

[51]  A. Sunjaya,et al.  Targeting ageing and preventing organ degeneration with metformin. , 2020, Diabetes & metabolism.

[52]  Bin Luo,et al.  Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons , 2020, Brain sciences.

[53]  M. Rahmanian,et al.  Metformin downregulates miR223 expression in insulin-resistant 3T3L1 cells and human diabetic adipose tissue , 2020, Endocrine.

[54]  P. Sachdev,et al.  Metformin Use Is Associated With Slowed Cognitive Decline and Reduced Incident Dementia in Older Adults With Type 2 Diabetes: The Sydney Memory and Ageing Study , 2020, Diabetes Care.

[55]  G. Shulman,et al.  Cellular and Molecular Mechanisms of Metformin Action , 2020, Endocrine reviews.

[56]  C. Ventura,et al.  Tuning Adipogenic Differentiation in ADSCs by Metformin and Vitamin D: Involvement of miRNAs , 2020, International journal of molecular sciences.

[57]  Chi-Ying F. Huang,et al.  Neoadjuvant metformin added to conventional chemotherapy synergizes anti-proliferative effects in ovarian cancer , 2020, Journal of Ovarian Research.

[58]  M. Bijak,et al.  Metformin as a Potential Agent in the Treatment of Multiple Sclerosis , 2020, International journal of molecular sciences.

[59]  N. Sata,et al.  Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus , 2020, Cancer science.

[60]  Nathan R. Stewart,et al.  Metformin May Contribute to Inter-individual Variability for Glycemic Responses to Exercise , 2020, Frontiers in Endocrinology.

[61]  Z. Shao,et al.  Natural killer cells in cancer biology and therapy , 2020, Molecular Cancer.

[62]  M. Nijsten,et al.  Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model , 2020, BMJ open diabetes research & care.

[63]  Zhihong He,et al.  Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression , 2020, Journal of Experimental & Clinical Cancer Research.

[64]  R. Smolarczyk,et al.  The World Health Organization (WHO) approach to healthy ageing , 2020, Maturitas.

[65]  R. Simó,et al.  Impact of antidiabetic agents on dementia risk: A Bayesian network meta-analysis. , 2020, Metabolism: clinical and experimental.

[66]  C. Apovian,et al.  Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation , 2020, Cell Metabolism.

[67]  N. Barzilai,et al.  Benefits of Metformin in Attenuating the Hallmarks of Aging. , 2020, Cell metabolism.

[68]  Yan Bian,et al.  Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis , 2020, Cell cycle.

[69]  Bin Zhang,et al.  Metformin Enhances the Antitumor Activity of CD8+ T Lymphocytes via the AMPK–miR-107–Eomes–PD-1 Pathway , 2020, The Journal of Immunology.

[70]  E. Pålsson-McDermott,et al.  Targeting immunometabolism as an anti-inflammatory strategy , 2020, Cell Research.

[71]  V. Dhawan,et al.  Metformin upregulates mitophagy in patients with T2DM: A randomized placebo‐controlled study , 2020, Journal of cellular and molecular medicine.

[72]  H. Grill,et al.  GDF15 Induces Anorexia through Nausea and Emesis. , 2020, Cell metabolism.

[73]  M. Markowicz-Piasecka,et al.  Pleiotropic Activity of Metformin and Its Sulfonamide Derivatives on Vascular and Platelet Haemostasis , 2019, Molecules.

[74]  S. O’Rahilly,et al.  GDF15 mediates the effects of metformin on body weight and energy balance , 2019, Nature.

[75]  Lulu Chen,et al.  High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155 , 2019, Nutrition & Metabolism.

[76]  Metformin , 2019, Reactions Weekly.

[77]  Yue Zhang,et al.  Metformin inhibits the function of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[78]  Amogelang R. Raphenya,et al.  Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss , 2019, Nature Metabolism.

[79]  G. Karimi,et al.  A review on the cardioprotective mechanisms of metformin against doxorubicin , 2019, Human & experimental toxicology.

[80]  O. Dreesen,et al.  Premature aging syndromes: From patients to mechanism. , 2019, Journal of dermatological science.

[81]  David A Bennett,et al.  Diagnosis and Management of Dementia: Review. , 2019, JAMA.

[82]  J. H. Kim,et al.  Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51 , 2019, Breast Cancer Research.

[83]  S. Dietmann,et al.  Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells , 2019, Cell stem cell.

[84]  K. Bryson,et al.  Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy , 2019, Cell.

[85]  S. Owumi,et al.  Hepatorenal protective effects of protocatechuic acid in rats administered with anticancer drug methotrexate , 2019, Human & experimental toxicology.

[86]  P. Gao,et al.  Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: a systematic review and an updated meta-analysis , 2019, Cardiovascular Diabetology.

[87]  M. Blasco,et al.  Telomere shortening rate predicts species life span , 2019, Proceedings of the National Academy of Sciences.

[88]  Zhiguang Zhou,et al.  Metformin shows anti‐inflammatory effects in murine macrophages through Dicer/microribonucleic acid‐34a‐5p and microribonucleic acid‐125b‐5p , 2019, Journal of diabetes investigation.

[89]  R. Michelucci,et al.  Treatment with metformin in twelve patients with Lafora disease , 2019, Orphanet Journal of Rare Diseases.

[90]  A. Larbi,et al.  Metformin Monotherapy Downregulates Diabetes-Associated Inflammatory Status and Impacts on Mortality , 2019, Front. Physiol..

[91]  M. Irwin,et al.  Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults. , 2019, The journals of gerontology. Series A, Biological sciences and medical sciences.

[92]  Jianqing Gao,et al.  Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment. , 2019, Molecular pharmaceutics.

[93]  K. Tan-No,et al.  Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression , 2019, Neuropharmacology.

[94]  D. Détaille,et al.  Role of Mitochondria in the Mechanism(s) of Action of Metformin , 2019, Front. Endocrinol..

[95]  H. Jang,et al.  Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells , 2019, Journal of Cancer.

[96]  J. Krystal,et al.  Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments , 2019, Neuron.

[97]  R. Duman,et al.  Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions , 2019, Front. Cell. Neurosci..

[98]  C. Mandarim-de-Lacerda,et al.  Metformin enhances mitochondrial biogenesis and thermogenesis in brown adipocytes of mice. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[99]  A. Carrillo-Vico,et al.  Peripheral CD39-expressing T regulatory cells are increased and associated with relapsing-remitting multiple sclerosis in relapsing patients , 2019, Scientific Reports.

[100]  M. Hipp,et al.  The proteostasis network and its decline in ageing , 2019, Nature Reviews Molecular Cell Biology.

[101]  Chong Gao,et al.  The proportion of peripheral regulatory T cells in patients with Multiple Sclerosis: A meta-analysis. , 2019, Multiple sclerosis and related disorders.

[102]  Yan Yang,et al.  Association between antidiabetic agents use and leukocyte telomere shortening rates in patients with type 2 diabetes , 2019, Aging.

[103]  E. Fontaine.  Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences , 2018, Front. Endocrinol..

[104]  S. M. Toor,et al.  Immune checkpoint inhibitors: recent progress and potential biomarkers , 2018, Experimental & Molecular Medicine.

[105]  D. Xiao,et al.  Novel application of metformin combined with targeted drugs on anticancer treatment , 2018, Cancer science.

[106]  J. Debnath,et al.  Autophagy and the cell biology of age-related disease , 2018, Nature Cell Biology.

[107]  Lucas C. Reineke,et al.  Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling , 2018, Molecular oncology.

[108]  I. Vancurova,et al.  Metformin as an Anticancer Agent. , 2018, Trends in pharmacological sciences.

[109]  A. Cazenave-Gassiot,et al.  Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling. , 2018, Developmental cell.

[110]  L. Partridge,et al.  Mutations of mitochondrial DNA are not major contributors to aging of fruit flies , 2018, Proceedings of the National Academy of Sciences.

[111]  T. Chowdhury,et al.  Metformin in cancer. , 2018, Diabetes research and clinical practice.

[112]  F. N. Emamzadeh,et al.  Parkinson’s Disease: Biomarkers, Treatment, and Risk Factors , 2018, Front. Neurosci..

[113]  V. Mazzaferro,et al.  Metformin Use Is Associated With Longer Progression-Free Survival of Patients With Diabetes and Pancreatic Neuroendocrine Tumors Receiving Everolimus and/or Somatostatin Analogues. , 2018, Gastroenterology.

[114]  W. Symmans,et al.  Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. , 2018, Molecular cell.

[115]  Weili Zhao,et al.  Metformin prolonged the survival of diffuse large B-cell lymphoma and grade 3b follicular lymphoma patients responding to first-line treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone: a prospective phase II clinical trial , 2018, Translational Cancer Research.

[116]  J. Fitzgerald,et al.  The Therapeutic Potential of Metformin in Neurodegenerative Diseases , 2018, Front. Endocrinol..

[117]  K. Rice,et al.  Organic Cation Transporter 3 Facilitates Fetal Exposure to Metformin during Pregnancy , 2018, Molecular Pharmacology.

[118]  S. Jakobsen,et al.  Metformin targets brown adipose tissue in vivo and reduces oxygen consumption in vitro , 2018, Diabetes, obesity & metabolism.

[119]  R. Lush,et al.  A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG‐asparaginase, and doxorubicin , 2018, Pediatric blood & cancer.

[120]  Baptiste N. Jaeger,et al.  Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. , 2018, Cell reports.

[121]  Q. Ma,et al.  Metformin's antitumour and anti‐angiogenic activities are mediated by skewing macrophage polarization , 2018, Journal of cellular and molecular medicine.

[122]  G. Bhagat,et al.  Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice , 2018, Nature.

[123]  Jiping Yang,et al.  Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7 , 2018, Aging cell.

[124]  D. Gibson,et al.  Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines , 2018, Front. Immunol..

[125]  N. Jain,et al.  Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[126]  Junmin Li,et al.  Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways , 2018, Journal of experimental & clinical cancer research : CR.

[127]  P. Bork,et al.  The Human Gut Microbiome: From Association to Modulation , 2018, Cell.

[128]  Xin'an Wu,et al.  The urinary excretion of metformin, ceftizoxime and ofloxacin in high serum creatinine rats: Can creatinine predict renal tubular elimination? , 2018, Life sciences.

[129]  M. Gholipourmalekabadi,et al.  Evaluation of metformin effects in the chronic phase of spontaneous seizures in pilocarpine model of temporal lobe epilepsy , 2018, Metabolic Brain Disease.

[130]  J. Mar,et al.  Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults , 2018, Aging cell.

[131]  T. Z. Waise,et al.  Metformin Alters Upper Small Intestinal Microbiota that Impact a Glucose-SGLT1-Sensing Glucoregulatory Pathway. , 2018, Cell metabolism.

[132]  R. Salehi,et al.  Metformin enhances doxorubicin sensitivity via inhibition of doxorubicin efflux in P‐gp‐overexpressing MCF‐7 cells , 2018, Chemical biology & drug design.

[133]  P. McColgan,et al.  Huntington's disease: a clinical review , 2018, European journal of neurology.

[134]  S. Sajdak,et al.  Angiogenesis and cancer stem cells: New perspectives on therapy of ovarian cancer. , 2017, European journal of medicinal chemistry.

[135]  L. Ferrucci,et al.  Aging, inflammation and the environment , 2017, Experimental Gerontology.

[136]  M. Jeschke,et al.  Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions , 2017, Endocrine reviews.

[137]  A. Dulamea.  The contribution of oligodendrocytes and oligodendrocyte progenitor cells to central nervous system repair in multiple sclerosis: perspectives for remyelination therapeutic strategies , 2017, Neural regeneration research.

[138]  J. Melo,et al.  Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition , 2017, Journal of the National Cancer Institute.

[139]  P. Liu,et al.  Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I , 2017, Cell Death and Disease.

[140]  P. Nayak,et al.  Metformin and ascorbic acid combination therapy ameliorates type 2 diabetes mellitus and comorbid depression in rats , 2017, Brain Research.

[141]  S. Hori,et al.  Attenuation of CD4+ CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug , 2017, EBioMedicine.

[142]  Etienne Sibille,et al.  Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives , 2017, Biological Psychiatry.

[143]  Yi Dai,et al.  Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy , 2017, Diabetes.

[144]  G. Jeong,et al.  Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease , 2017, Neuropharmacology.

[145]  Yong He,et al.  Vorinostat and metformin sensitize EGFR-TKI resistant NSCLC cells via BIM-dependent apoptosis induction , 2017, Oncotarget.

[146]  M. V. Vander Heiden,et al.  Targeting Metabolism for Cancer Therapy. , 2017, Cell chemical biology.

[147]  Rong Li,et al.  Metformin improves obesity-associated inflammation by altering macrophages polarization , 2017, Molecular and Cellular Endocrinology.

[148]  C. Bailey,et al.  Metformin: historical overview , 2017, Diabetologia.

[149]  T. Cash-Mason,et al.  GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates , 2017, Nature Medicine.

[150]  P. Emmerson,et al.  The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL , 2017, Nature Medicine.

[151]  Z. Xiao,et al.  Metformin Sensitizes Leukemia Cells to Vincristine via Activation of AMP-activated Protein Kinase , 2017, Journal of Cancer.

[152]  T. Misteli,et al.  Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases , 2017, Nature Reviews Molecular Cell Biology.

[153]  L. Bettedi,et al.  Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing , 2017, Biogerontology.

[154]  D. Hardie,et al.  The mechanisms of action of metformin , 2017, Diabetologia.

[155]  L. Ford,et al.  Repurposing metformin for the prevention of cancer and cancer recurrence , 2017, Diabetologia.

[156]  J. Millán,et al.  Metformin intake associates with better cognitive function in patients with Huntington's disease , 2017, PloS one.

[157]  R. Shaw,et al.  AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance. , 2017, Molecular cell.

[158]  E. Mikiciuk-Olasik,et al.  Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics. , 2017, Current pharmaceutical design.

[159]  R. Duman,et al.  Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression , 2017, Current Opinion in Behavioral Sciences.

[160]  L. Klotz,et al.  The Effect of Metformin Use during Docetaxel Chemotherapy on Prostate Cancer Specific and Overall Survival of Diabetic Patients with Castration Resistant Prostate Cancer , 2017, The Journal of urology.

[161]  David Carling,et al.  AMPK signalling in health and disease. , 2017, Current opinion in cell biology.

[162]  S. Espinoza,et al.  Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. , 2017, Journal of diabetes and its complications.

[163]  S. Jong,et al.  Anti-tumor effects of everolimus and metformin are complementary and glucose-dependent in breast cancer cells , 2017, BMC Cancer.

[164]  Yida Hu,et al.  Chronic metformin treatment facilitates seizure termination. , 2017, Biochemical and biophysical research communications.

[165]  M. Chiang,et al.  Metformin activation of AMPK suppresses AGE‐induced inflammatory response in hNSCs , 2017, Experimental cell research.

[166]  Mei Peng,et al.  Combination of metformin with chemotherapeutic drugs via different molecular mechanisms. , 2017, Cancer treatment reviews.

[167]  Maximilian Kleinert,et al.  Exercise-stimulated glucose uptake — regulation and implications for glycaemic control , 2017, Nature Reviews Endocrinology.

[168]  Haiyang Xie,et al.  Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1 , 2017, Journal of Hematology & Oncology.

[169]  Ichiro Tokubuchi,et al.  Beneficial effects of metformin on energy metabolism and visceral fat volume through a possible mechanism of fatty acid oxidation in human subjects and rats , 2017, PloS one.

[170]  Chien-Hsing Lee,et al.  Metformin-treated cancer cells modulate macrophage polarization through AMPK-NF-κB signaling , 2017, Oncotarget.

[171]  M. Philip,et al.  CD8+ T cell differentiation and dysfunction in cancer , 2016, Nature Reviews Immunology.

[172]  E. Boerwinkle,et al.  Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. , 2016, Blood.

[173]  R. Riechelmann,et al.  Phase 2 Trial of Metformin Combined With 5-Fluorouracil in Patients With Refractory Metastatic Colorectal Cancer. , 2016, Clinical colorectal cancer.

[174]  S. Ye,et al.  Effects of metformin on blood and urine pro-inflammatory mediators in patients with type 2 diabetes , 2016, Journal of Inflammation.

[175]  Eosu Kim,et al.  Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice , 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[176]  R. Langley,et al.  Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[177]  D. Mohr,et al.  Major depressive disorder , 2016, Nature Reviews Disease Primers.

[178]  B. Kemp,et al.  Metformin Prevents Nigrostriatal Dopamine Degeneration Independent of AMPK Activation in Dopamine Neurons , 2016, PloS one.

[179]  K. Harada,et al.  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma. , 2016, International journal of oncology.

[180]  De-guang Sun,et al.  Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP , 2016, Oncotarget.

[181]  S. Kritchevsky,et al.  Metformin as a Tool to Target Aging. , 2016, Cell metabolism.

[182]  K. Giacomini,et al.  The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin , 2016, Clinical Pharmacokinetics.

[183]  Qifu Li,et al.  AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity , 2016, Diabetes.

[184]  Ming Lu,et al.  Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance , 2016, The international journal of neuropsychopharmacology.

[185]  J. Correale,et al.  Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis. , 2016, JAMA neurology.

[186]  Xiu-Li Guo,et al.  Combinational strategies of metformin and chemotherapy in cancers , 2016, Cancer Chemotherapy and Pharmacology.

[187]  A. Kavelaars,et al.  Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice , 2016, PloS one.

[188]  R. de Cabo,et al.  Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence , 2016, Aging cell.

[189]  D. Ingram,et al.  Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice , 2016, Behavioural Brain Research.

[190]  R. Youle,et al.  The Mitochondrial Basis of Aging. , 2016, Molecular cell.

[191]  C. Bailey,et al.  Metformin and the gastrointestinal tract , 2016, Diabetologia.

[192]  Ruisheng Song.  Mechanism of Metformin: A Tale of Two Sites , 2016, Diabetes Care.

[193]  V. Okpashi,et al.  Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats , 2015, Journal of diabetes research.

[194]  Jürgen Winkler,et al.  Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. , 2015, Cell stem cell.

[195]  D. Baker,et al.  Cellular senescence in aging and age-related disease: from mechanisms to therapy , 2015, Nature Medicine.

[196]  R. Martins,et al.  The role of type 2 diabetes in neurodegeneration , 2015, Neurobiology of Disease.

[197]  H. Yokoyama,et al.  Risk factors associated with abnormal cognition in Japanese outpatients with diabetes, hypertension or dyslipidemia , 2015, Diabetology International.

[198]  K. Giacomini,et al.  Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). , 2015, Molecular pharmaceutics.

[199]  Yuehua Wu,et al.  Metformin ameliorates the proinflammatory state in patients with carotid artery atherosclerosis through sirtuin 1 induction. , 2015, Translational research : the journal of laboratory and clinical medicine.

[200]  Qiaojun He,et al.  Metformin prevents cancer metastasis by inhibiting M2-like polarization of tumor associated macrophages , 2015, Oncotarget.

[201]  Jens Roat Kultima,et al.  Disentangling the effects of type 2 diabetes and metformin on the human gut microbiota , 2016 .

[202]  Xuan Yang,et al.  Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling , 2015, Scientific Reports.

[203]  M. Hashemitabar,et al.  Glucose plus metformin compared with glucose alone on β-cell function in mouse pancreatic islets. , 2015, Biomedical reports.

[204]  Y. Saisho.  Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect. , 2015, Endocrine, metabolic & immune disorders drug targets.

[205]  R. DeFronzo,et al.  The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies , 2015, Diabetes Care.

[206]  Jie Yang,et al.  Histone H3k9 and H3k27 Acetylation Regulates IL‐4/STAT6‐Mediated Igε Transcription in B Lymphocytes , 2015, Anatomical record.

[207]  Joung-Sun Park,et al.  Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway , 2015, Mechanisms of Ageing and Development.

[208]  K. Giacomini,et al.  Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin , 2015, Molecular Pharmacology.

[209]  M. Morsy,et al.  Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats , 2015, Mediators of inflammation.

[210]  K. Højlund,et al.  Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers , 2015, European Journal of Clinical Pharmacology.

[211]  N. Chen,et al.  Selective modulation of microglia polarization to M2 phenotype for stroke treatment. , 2015, International immunopharmacology.

[212]  M. Derwahl,et al.  Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells. , 2015, Oncology reports.

[213]  De-guang Sun,et al.  Metformin sensitizes hepatocellular carcinoma to arsenic trioxide-induced apoptosis by downregulating Bcl2 expression , 2015, Tumor Biology.

[214]  D. Thakker,et al.  Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers , 2015, The Journal of Pharmacology and Experimental Therapeutics.

[215]  M. White,et al.  Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase , 2015, Cell.

[216]  M. Mehta,et al.  Targeting metabolism for lupus therapy , 2015, Science Translational Medicine.

[217]  E. Lengyel,et al.  Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models. , 2015, American journal of obstetrics and gynecology.

[218]  F. Wondisford,et al.  Metformin action: concentrations matter. , 2015, Cell metabolism.

[219]  H. Udono,et al.  Immune-mediated antitumor effect by type 2 diabetes drug, metformin , 2015, Proceedings of the National Academy of Sciences.

[220]  C. Aliberti,et al.  Metformin: a modulator of bevacizumab activity in cancer? A case report , 2015, Cancer biology & therapy.

[221]  A. Morris,et al.  Metformin in cancer treatment and prevention. , 2015, Annual review of medicine.

[222]  Y. Choi.  Efficacy of Adjunctive Treatments Added to Olanzapine or Clozapine for Weight Control in Patients with Schizophrenia: A Systematic Review and Meta-Analysis , 2015, TheScientificWorldJournal.

[223]  B. Viollet,et al.  Metformin: from mechanisms of action to therapies. , 2014, Cell metabolism.

[224]  Y. Tsai,et al.  Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[225]  S. Sathaye,et al.  Neuroprotective effect of metformin in MPTP-induced Parkinson’s disease in mice , 2014, Neuroscience.

[226]  Shun-Fa Yang,et al.  Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression , 2014, Amino Acids.

[227]  Y. Chern,et al.  AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease. , 2014, Biochimica et biophysica acta.

[228]  Jing-lu Wang,et al.  Regulation of insulin-like growth factor signaling by metformin in endometrial cancer cells , 2014, Oncology letters.

[229]  J. Padbury,et al.  Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study , 2014, PloS one.

[230]  R. Bernards,et al.  Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation , 2014, International journal of cancer.

[231]  Jian Cheng,et al.  Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke , 2014, Brain, Behavior, and Immunity.

[232]  A. Renehan,et al.  Diabetes and cancer: 5 years into the recent controversy. , 2014, European journal of cancer.

[233]  P. Ganey,et al.  Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[234]  John Kurhanewicz,et al.  OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin , 2014, Proceedings of the National Academy of Sciences.

[235]  Y. Qi,et al.  Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer , 2014, Journal of the National Cancer Institute.

[236]  Wei-Ping Wang,et al.  Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice. , 2014, Biochemical and biophysical research communications.

[237]  C. Franceschi,et al.  Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[238]  Xinbing Sui,et al.  Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation , 2014, PloS one.

[239]  J. Ajani,et al.  Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer , 2014, International journal of oncology.

[240]  Michael J. MacDonald,et al.  Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase , 2014, Nature.

[241]  G. Davies,et al.  Metformin and Berberine Prevent Olanzapine-Induced Weight Gain in Rats , 2014, PloS one.

[242]  Qifu Li,et al.  Metformin Ameliorates Hepatic Steatosis and Inflammation without Altering Adipose Phenotype in Diet-Induced Obesity , 2014, PloS one.

[243]  T. Ninomiya,et al.  Diabetes Mellitus and Dementia , 2014, Current Diabetes Reports.

[244]  I. Pernicova,et al.  Metformin—mode of action and clinical implications for diabetes and cancer , 2014, Nature Reviews Endocrinology.

[245]  Wei Huang,et al.  Metformin Plays a Dual Role in MIN6 Pancreatic β Cell Function through AMPK-dependent Autophagy , 2014, International journal of biological sciences.

[246]  Tzeng-Ji Chen,et al.  Metformin-inclusive therapy reduces the risk of stroke in patients with diabetes: a 4-year follow-up study. , 2014, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[247]  M. Eryılmaz,et al.  Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson's Disease , 2013, Current gerontology and geriatrics research.

[248]  J. Dyck,et al.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin , 2013, Nature Medicine.

[249]  H. Kusuhara,et al.  Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. , 2013, Journal of pharmaceutical sciences.

[250]  I. Singh,et al.  AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model. , 2013, The American journal of pathology.

[251]  E. Mercken,et al.  Metformin improves healthspan and lifespan in mice , 2013, Nature Communications.

[252]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[253]  G. Ferbeyre,et al.  Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κB activation , 2013, Aging cell.

[254]  Fredrik H. Karlsson,et al.  Gut metagenome in European women with normal, impaired and diabetic glucose control , 2013, Nature.

[255]  R. Andersson,et al.  Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells , 2013, BMC Cancer.

[256]  J. Prehn,et al.  Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death , 2013, Cell Death and Disease.

[257]  David Weinkove,et al.  Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism , 2013, Cell.

[258]  F. Berrino,et al.  Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects , 2013, Oncogene.

[259]  David T. W. Jones,et al.  Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas , 2013, Acta Neuropathologica.

[260]  Hea‐Young Cho,et al.  Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects , 2013, The AAPS Journal.

[261]  Yun-Wei Lin,et al.  Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel. , 2013, Biochemical pharmacology.

[262]  Z. Canturk,et al.  The effect of metformin on mean platelet volume in dıabetıc patients , 2013, Platelets.

[263]  Warren Tong,et al.  Effect of Concomitant Administration of Trospium Chloride Extended Release on the Steady-State Pharmacokinetics of Metformin in Healthy Adults , 2013, Clinical Drug Investigation.

[264]  Takla Griss,et al.  AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo. , 2013, Cell metabolism.

[265]  G. Sambuceti,et al.  Metformin selectively affects human glioblastoma tumor-initiating cell viability , 2013, Cell Cycle.

[266]  K. Struhl,et al.  Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth , 2012, Proceedings of the National Academy of Sciences.

[267]  B. Okopień,et al.  Haemostatic Effects of Metformin in Simvastatin‐Treated Volunteers with Impaired Fasting Glucose , 2012, Basic & clinical pharmacology & toxicology.

[268]  C. Elmets,et al.  Metformin, an Antidiabetic Agent Reduces Growth of Cutaneous Squamous Cell Carcinoma by Targeting mTOR Signaling Pathway † , 2012, Photochemistry and photobiology.

[269]  Jing Wang,et al.  Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. , 2012, Cell stem cell.

[270]  Chih-Cheng Hsu,et al.  Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort. , 2012, Parkinsonism & related disorders.

[271]  C. la Vecchia,et al.  Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. , 2012, The oncologist.

[272]  Anwar H Nassar,et al.  Pregnancy outcomes and the effect of metformin treatment in women with polycystic ovary syndrome: an overview , 2012, Acta obstetricia et gynecologica Scandinavica.

[273]  H. Korashy,et al.  Metformin Rescues the Myocardium from Doxorubicin-Induced Energy Starvation and Mitochondrial Damage in Rats , 2012, Oxidative medicine and cellular longevity.

[274]  S. Jick,et al.  Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population‐Based Case–Control Study , 2012, Journal of the American Geriatrics Society.

[275]  Pratap N. Kumar,et al.  Effects of metformin use in pregnant patients with polycystic ovary syndrome , 2012, Journal of human reproductive sciences.

[276]  Chunxiao Zhou,et al.  Metformin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and modulation of the mTOR pathway. , 2012, Gynecologic oncology.

[277]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[278]  V. Trajković,et al.  Intracerebroventricular Administration of Metformin Inhibits Ghrelin-Induced Hypothalamic AMP-Kinase Signalling and Food Intake , 2012, Neuroendocrinology.

[279]  M. Derwahl,et al.  Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells, and potentiates the effect of chemotherapeutic agents. , 2012, The Journal of clinical endocrinology and metabolism.

[280]  Tae Woo Jung,et al.  Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway. , 2012, Biochemical and biophysical research communications.

[281]  Xiulian Sun,et al.  Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease , 2012, Journal of neurochemistry.

[282]  L. Platanias,et al.  Antileukemic effects of AMPK activators on BCR-ABL-expressing cells. , 2011, Blood.

[283]  B. Viollet,et al.  Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status , 2011, Diabetologia.

[284]  A. Thor,et al.  Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions , 2011, Cell cycle.

[285]  Yonghua Yang.  Metformin for cancer prevention , 2011, Frontiers of medicine.

[286]  A. Yasmeen,et al.  Induction of apoptosis by metformin in epithelial ovarian cancer: involvement of the Bcl-2 family proteins. , 2011, Gynecologic oncology.

[287]  E. Castrén,et al.  Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy , 2011, Neurobiology of Disease.

[288]  B Luscher,et al.  The GABAergic deficit hypothesis of major depressive disorder , 2011, Molecular Psychiatry.

[289]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[290]  L. Pellerin,et al.  The anorexigenic effects of metformin involve increases in hypothalamic leptin receptor expression. , 2011, Metabolism: clinical and experimental.

[291]  Hyung Gyun Kim,et al.  Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation , 2011, British journal of pharmacology.

[292]  X. Leverve,et al.  Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin , 2011, Cell Death and Disease.

[293]  Ari,et al.  Bioequivalence Study of Metformin HCl XR Caplet Formulations in Healthy Indonesian Volunteers , 2011 .

[294]  R. Day,et al.  Clinical Pharmacokinetics of Metformin , 2011, Clinical pharmacokinetics.

[295]  V. Anisimov,et al.  If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice , 2011, Aging.

[296]  Heinz Drexel,et al.  Brown versus White Adipose Tissue: A Mini-Review , 2010, Gerontology.

[297]  D. Balzi,et al.  Metformin and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients , 2010, Diabetes Care.

[298]  I. Singh,et al.  Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis. , 2010, Biochemical and biophysical research communications.

[299]  P. Harari,et al.  Understanding resistance to EGFR inhibitors—impact on future treatment strategies , 2010, Nature Reviews Clinical Oncology.

[300]  T. Freund,et al.  Loss and reorganization of calretinin-containing interneurons in the epileptic human hippocampus. , 2010, Brain : a journal of neurology.

[301]  J. Auwerx,et al.  AMP-activated protein kinase and its downstream transcriptional pathways , 2010, Cellular and Molecular Life Sciences.

[302]  A. Zajac,et al.  T‐cell exhaustion: characteristics, causes and conversion , 2010, Immunology.

[303]  M. Pollak,et al.  Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells , 2010, Breast Cancer Research and Treatment.

[304]  T. Hansen,et al.  Huntington’s Disease Does Not Appear to Increase the Risk of Diabetes Mellitus , 2009, Journal of neuroendocrinology.

[305]  K. Lim,et al.  Protein misfolding and aggregation in Parkinson's disease. , 2009, Antioxidants & redox signaling.

[306]  F. Wondisford,et al.  Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein , 2009, Cell.

[307]  H. Shill,et al.  Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction , 2009, Acta Neuropathologica.

[308]  Huaxi Xu,et al.  Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription , 2009, Proceedings of the National Academy of Sciences.

[309]  R. Maccioni,et al.  Insulin resistance and Alzheimer's disease: molecular links & clinical implications. , 2008, Current Alzheimer research.

[310]  V. Anisimov,et al.  Metformin slows down aging and extends life span of female SHR mice , 2008, Cell cycle.

[311]  S. Higuchi,et al.  Polymorphism in human organic cation transporters and metformin action. , 2008, Pharmacogenomics.

[312]  E. Salpeter,et al.  Meta-analysis: metformin treatment in persons at risk for diabetes mellitus. , 2008, The American journal of medicine.

[313]  Joanne Wang,et al.  Metformin Transport by a Newly Cloned Proton-Stimulated Organic Cation Transporter (Plasma Membrane Monoamine Transporter) Expressed in Human Intestine , 2007, Drug Metabolism and Disposition.

[314]  Nathalie Arbour,et al.  Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation , 2007, Nature Medicine.

[315]  J. Auwerx,et al.  Transcriptional coregulators in the control of energy homeostasis. , 2007, Trends in cell biology.

[316]  F. Pralong,et al.  Metformin inhibits adenosine 5'-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons. , 2007, Endocrinology.

[317]  H. Waki,et al.  Endocrine functions of adipose tissue. , 2007, Annual review of pathology.

[318]  A. Chinnaiyan,et al.  Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins. , 2006, Arthritis and rheumatism.

[319]  M. Rigoulet,et al.  The ROS Production Induced by a Reverse-Electron Flux at Respiratory-Chain Complex 1 is Hampered by Metformin , 2006, Journal of bioenergetics and biomembranes.

[320]  H. McLeod,et al.  Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritis. , 2006, Arthritis and rheumatism.

[321]  J. Huh,et al.  Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. , 2006, Diabetes.

[322]  E. Ferrannini,et al.  Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review , 2006, Diabetologia.

[323]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[324]  R. Neubert,et al.  Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). , 2005, Biochemical pharmacology.

[325]  S. Fowler,et al.  Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin. , 2005, Diabetes.

[326]  Napoleone Ferrara,et al.  Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. , 2005, Cancer research.

[327]  G. Johnson,et al.  Tau phosphorylation in neuronal cell function and dysfunction , 2004, Journal of Cell Science.

[328]  Kenneth J. Hillan,et al.  Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer , 2004, Nature Reviews Drug Discovery.

[329]  Pgce CBiol Honorary Senior Fellow C Day PhD,et al.  Metformin: its botanical background , 2004 .

[330]  D. Hall,et al.  Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans , 2003, Science.

[331]  R. Huupponen,et al.  Differential effects of rosiglitazone and metformin on adipose tissue distribution and glucose uptake in type 2 diabetic subjects. , 2003, Diabetes.

[332]  Hansjürgen Bratzke,et al.  Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) , 2002, Journal of Neurology.

[333]  Samy I McFarlane,et al.  Metformin: An Update , 2002, Annals of Internal Medicine.

[334]  G F Mason,et al.  Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments , 2002, Molecular Psychiatry.

[335]  C. Glueck,et al.  Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. , 2001, Metabolism: clinical and experimental.

[336]  F. Kuhajda,et al.  Metformin reverses fatty liver disease in obese, leptin-deficient mice , 2000, Nature Medicine.

[337]  M. Owen,et al.  Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. , 2000, The Biochemical journal.

[338]  R. Vigneri,et al.  Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells. , 2000, Diabetes.

[339]  M. Rigoulet,et al.  Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I* , 2000, The Journal of Biological Chemistry.

[340]  R. Donnelly,et al.  The UK prospective diabetes study (UKPDS): clinical and therapeutic implications for type 2 diabetes. , 1999, British journal of clinical pharmacology.

[341]  Paolisso,et al.  Effect of metformin on food intake in obese subjects , 1998, European journal of clinical investigation.

[342]  A. Scheen.  Clinical Pharmacokinetics of Metformin , 1996, Clinical pharmacokinetics.

[343]  B. Meldrum.  Excitotoxicity and Selective Neuronal Loss in Epilepsy , 1993, Brain pathology.

[344]  C. Bailey,et al.  Traditional Plant Medicines as Treatments for Diabetes , 1989, Diabetes Care.

[345]  T. Kondo,et al.  Occurrence of Guanidino Compounds in Several Plants , 1986 .

[346]  H Connor,et al.  Metformin kinetics in healthy subjects and in patients with diabetes mellitus. , 1981, British journal of clinical pharmacology.

[347]  G. Franceschini,et al.  Disposition of metformin (N,N‐dimethylbiguanide) in man , 1978, Clinical pharmacology and therapeutics.

[348]  G. Ungar,et al.  Pharmacological Studies of a New Oral Hypoglycemic Drug , 1957, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[349]  D. G. Davey,et al.  Studies on synthetic antimalarial drugs; some biguanide derivatives as new types of antimalarial substances with both therapeutic and causal prophylactic activity. , 1945, Annals of tropical medicine and parasitology.

[350]  C. Taft,et al.  Parkinson's disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment. , 2019, Mini reviews in medicinal chemistry.

[351]  R. Tesi.  MDSC; the Most Important Cell You Have Never Heard Of. , 2019, Trends in pharmacological sciences.

[352]  O. Abulseoud,et al.  Effects of metformin on apoptosis and α-synuclein in a rat model of pentylenetetrazole-induced epilepsy. , 2019, Canadian journal of physiology and pharmacology.

[353]  Erica C. Rosa,et al.  Leukocyte telomere length correlates with glucose control in adults with recently diagnosed type 2 diabetes. , 2018, Diabetes research and clinical practice.

[354]  In-kyu Lee,et al.  Metformin prevents glucotoxicity by alleviating oxidative and ER stress-induced CD36 expression in pancreatic beta cells. , 2017, Journal of diabetes and its complications.

[355]  J. Kestle.  Clinical Trials , 2014, World Journal of Surgery.

[356]  N. Hakooz,et al.  Metformin IR versus XR Pharmacokinetics in Humans , 2011 .

[357]  P. Marathe,et al.  Steady-State Pharmacokinetics of a Novel Extended-Release Metformin Formulation , 2005, Clinical pharmacokinetics.

[358]  J. Morley,et al.  Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. , 1998, Obesity research.

[359]  C. Zancanaro,et al.  Lack of effect of intravenous metformin on plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in non-diabetic subjects. , 1984, Current medical research and opinion.