An Approach to the Assessment of Diabetic Neuropathy Based on Dynamic Pupillometry

Autonomic neuropathy (AN) is a common and serious complication of diabetes. Early detection is essential to enable appropriate interventional therapy. It has long been recognized that subjects with diabetic peripheral neuropathy (DPN) are at much greater risk of developing AN, but there is currently no simple screening tool to assess them. The aim of this study was to investigate pupil responsiveness in diabetic subjects with and without DPN using dynamic pupillometry. During the first test, one flash was administered and the pupil response recorded for 3 seconds. In the second test, twenty-five flashes at one-second intervals were administered and the pupil response recorded for 30 seconds. Several time related parameters were computed from the results. A total of 29 diabetic subjects (17 no DPN, 12 DPN) and 25 healthy volunteers took part in the study. In the first test, pupil-iris ratios in darkness, large deviation and plateau were significantly different between groups. Latency time from flash exposure to the start of constriction was significantly longer in diabetic subjects with DPN compared to healthy volunteers. There was no difference in latency times of largest deviation, plateau or duration of constriction between groups. In the second test, the pupil-iris ratios evaluated in the frame preceding the tenth and the twenty-fifth light flash were significantly greater in healthy volunteers than diabetic subjects with DPN. Latency time from the tenth and twenty-fifth flash exposure to the start of constriction was significantly shorter in healthy volunteers than in diabetic subjects with DPN. Our results show that diabetic subjects with DPN have sympathetic and parasympathetic dysfunction evidenced by diminished amplitude reflexes and significant smaller pupil diameter. Dynamic pupillometry may provide a simple, inexpensive and non-invasive tool to screen high-risk diabetic patients for diabetic autonomic neuropathy.

[1]  Georg Michelson,et al.  Pupillography refines the diagnosis of diabetic autonomic neuropathy , 2004, Journal of the Neurological Sciences.

[2]  F. Bremner,et al.  Pupil findings in a consecutive series of 150 patients with generalised autonomic neuropathy , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[3]  S. Smith,et al.  Reduced pupillary light reflexes in diabetic autonomic neuropathy , 1983, Diabetologia.

[4]  M. Cahill,et al.  Pupillary autonomic denervation with increasing duration of diabetes mellitus , 2001, The British journal of ophthalmology.

[5]  R. Freeman,et al.  Diabetic autonomic neuropathy. , 2003, Diabetes care.

[6]  Peter Bacchetti,et al.  Pupil examination: validity and clinical utility of an automated pupillometer. , 2005, The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.

[7]  S. Smith,et al.  Evidence for a neuropathic aetiology in the small pupil of diabetes mellitus. , 1983, The British journal of ophthalmology.

[8]  K. Fountoulakis,et al.  Automated standardized pupillometry with optical method for purposes of clinical practice and research. , 2000, Clinical physiology.

[9]  Fion D Bremner,et al.  Pupil abnormalities in selected autonomic neuropathies. , 2006, Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society.

[10]  Hendrik Lehnert,et al.  Pupil signs of sympathetic autonomic neuropathy in patients with type 1 diabetes. , 2002, Diabetes care.

[11]  S A Smith,et al.  A Simple Diagnostic Test for Pupillary Abnormality in Diabetic Autonomic Neuropathy , 1986, Diabetic medicine : a journal of the British Diabetic Association.