Vascularization Strategies for Bone Regeneration

[1]  N. Plesnila,et al.  The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo. , 2013, Acta biomaterialia.

[2]  R. Guldberg,et al.  Recovery from hind limb ischemia enhances rhBMP-2-mediated segmental bone defect repair in a rat composite injury model. , 2013, Bone.

[3]  Robert E Guldberg,et al.  Attenuated human bone morphogenetic protein-2-mediated bone regeneration in a rat model of composite bone and muscle injury. , 2013, Tissue engineering. Part C, Methods.

[4]  D. Gazit,et al.  Oxygenated environment enhances both stem cell survival and osteogenic differentiation. , 2013, Tissue engineering. Part A.

[5]  S. Komarova,et al.  Perfluorodecalin and bone regeneration. , 2013, European cells & materials.

[6]  A. Khademhosseini,et al.  Building Vascular Networks , 2012, Science Translational Medicine.

[7]  K. Ihara,et al.  Stimulation of neo-angiogenesis by combined use of irradiated and vascularized living bone graft for oncological reconstruction. , 2012, Surgical oncology.

[8]  J. Chan,et al.  Soft-tissue reconstruction of open fractures of the lower limb: muscle versus fasciocutaneous flaps. , 2012, Plastic and reconstructive surgery.

[9]  R. Guldberg,et al.  Effects of in vivo mechanical loading on large bone defect regeneration , 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  T. Einhorn,et al.  Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis. , 2012, Bone.

[11]  A. Rabie,et al.  The role of vascular endothelial growth factor in ossification , 2012, International Journal of Oral Science.

[12]  M. Saint-Geniez,et al.  Role of shear-stress-induced VEGF expression in endothelial cell survival , 2012, Journal of Cell Science.

[13]  Laxminarayanan Krishnan,et al.  Determinants of Microvascular Network Topologies in Implanted Neovasculatures , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[14]  Renjing Liu,et al.  Myogenic progenitors contribute to open but not closed fracture repair , 2011, BMC musculoskeletal disorders.

[15]  Bin Zhou,et al.  Stem cell engraftment and survival in the ischemic heart. , 2011, The Annals of thoracic surgery.

[16]  G. Zimmermann,et al.  Allograft bone matrix versus synthetic bone graft substitutes. , 2011, Injury.

[17]  Robert E Guldberg,et al.  Mechanical regulation of vascular growth and tissue regeneration in vivo , 2011, Proceedings of the National Academy of Sciences.

[18]  Andrés J. García,et al.  Effects of protein dose and delivery system on BMP-mediated bone regeneration. , 2011, Biomaterials.

[19]  M. Schenker,et al.  Angiogenesis in bone regeneration. , 2011, Injury.

[20]  Dong Hun Lee,et al.  Stromal Vascular Fraction From Adipose Tissue Forms Profound Vascular Network Through the Dynamic Reassembly of Blood Endothelial Cells , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[21]  Esther Novosel,et al.  Vascularization is the key challenge in tissue engineering. , 2011, Advanced drug delivery reviews.

[22]  David Eglin,et al.  Short-term cultivation of in situ prevascularized tissue constructs accelerates inosculation of their preformed microvascular networks after implantation into the host tissue. , 2011, Tissue engineering. Part A.

[23]  Dan Jin,et al.  Osteogenesis and angiogenesis of tissue-engineered bone constructed by prevascularized β-tricalcium phosphate scaffold and mesenchymal stem cells. , 2010, Biomaterials.

[24]  J. Hoying,et al.  Angiogenic Potential of Microvessel Fragments is Independent of the Tissue of Origin and can be Influenced by the Cellular Composition of the Implants , 2010, Microcirculation.

[25]  Stefan Milz,et al.  Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma. , 2010, Biomaterials.

[26]  Jacqueline Alblas,et al.  The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs. , 2010, Tissue engineering. Part A.

[27]  Andreas Hess,et al.  Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model , 2010, Journal of tissue engineering and regenerative medicine.

[28]  S. Scaglione,et al.  Short-time survival and engraftment of bone marrow stromal cells in an ectopic model of bone regeneration. , 2010, Tissue engineering. Part A.

[29]  J. Glowacki,et al.  Cell-free and cell-based approaches for bone regeneration , 2009, Nature Reviews Rheumatology.

[30]  David J. Mooney,et al.  Inspiration and application in the evolution of biomaterials , 2009, Nature.

[31]  Tal Dvir,et al.  Prevascularization of cardiac patch on the omentum improves its therapeutic outcome , 2009, Proceedings of the National Academy of Sciences.

[32]  W. Tawackoli,et al.  The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo. , 2009, Biomaterials.

[33]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[34]  Steven C George,et al.  Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. , 2009, Tissue engineering. Part A.

[35]  Z. Ungvari,et al.  Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression. , 2009, Antioxidants & redox signaling.

[36]  M. Lek,et al.  Myoblast sensitivity and fibroblast insensitivity to osteogenic conversion by BMP-2 correlates with the expression of Bmpr-1a , 2009, BMC musculoskeletal disorders.

[37]  J. Nanchahal,et al.  Improving lower limb salvage following fractures with vascular injury: a systematic review and new management algorithm. , 2009, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[38]  S. Levenberg,et al.  Vascularization--the conduit to viable engineered tissues. , 2009, Tissue engineering. Part B, Reviews.

[39]  Antonios G Mikos,et al.  Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. , 2008, Bone.

[40]  S. Badylak,et al.  A perivascular origin for mesenchymal stem cells in multiple human organs. , 2008, Cell stem cell.

[41]  W. Mutschler,et al.  Hypoxia in static and dynamic 3D culture systems for tissue engineering of bone. , 2008, Tissue engineering. Part A.

[42]  Benjamin J Ellis,et al.  Effect of mechanical boundary conditions on orientation of angiogenic microvessels. , 2008, Cardiovascular research.

[43]  S. Lynch,et al.  Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet‐derived growth factor‐bb and an injectable beta‐tricalcium phosphate/collagen matrix , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[44]  Helen Song,et al.  Interaction of angiogenic microvessels with the extracellular matrix. , 2007, American journal of physiology. Heart and circulatory physiology.

[45]  A. Rabie,et al.  VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification , 2007, Journal of dental research.

[46]  N. Ashammakhi,et al.  Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. , 2007, The Journal of bone and joint surgery. British volume.

[47]  D. C. Genetos,et al.  Hypoxia regulates PGE2 release and EP1 receptor expression in osteoblastic cells , 2007, Journal of cellular physiology.

[48]  J. Gimble,et al.  Adipose-derived stem cells for regenerative medicine. , 2007, Circulation research.

[49]  Diane Hu,et al.  Ischemia leads to delayed union during fracture healing: A mouse model , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[50]  A. Ladd,et al.  Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues. , 2006, The Journal of bone and joint surgery. American volume.

[51]  M. Menger,et al.  Impact of severity of local soft-tissue trauma on long-term manifestation of microcirculatory and microlymphatic dysfunctions. , 2006, The Journal of trauma.

[52]  Jeroen Rouwkema,et al.  Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. , 2006, Tissue engineering.

[53]  Andreas Hess,et al.  Engineering of vascularized transplantable bone tissues: induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop. , 2006, Tissue engineering.

[54]  M. Hedrick,et al.  Fat tissue: an underappreciated source of stem cells for biotechnology. , 2006, Trends in biotechnology.

[55]  J. Street,et al.  Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism , 2009, Journal of orthopaedic surgery and research.

[56]  D. Kohane,et al.  Engineering vascularized skeletal muscle tissue , 2005, Nature Biotechnology.

[57]  D. Kaplan,et al.  In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering. , 2005, Biomaterials.

[58]  Z. Ungvari,et al.  Regulation of Bone Morphogenetic Protein-2 Expression in Endothelial Cells , 2005 .

[59]  S. Doty,et al.  Thrombin peptide (TP508) promotes fracture repair by up‐regulating inflammatory mediators, early growth factors, and increasing angiogenesis , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[60]  J. Ryaby,et al.  Bone formation is enhanced by thrombin‐related peptide TP508 during distraction osteogenesis , 2005, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[61]  Joseph P Vacanti,et al.  Reconstruction of mandibular defects with autologous tissue-engineered bone. , 2004, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[62]  Gabriel Gruionu,et al.  Rapid Perfusion and Network Remodeling in a Microvascular Construct After Implantation , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[63]  Mingyao Liu,et al.  Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium , 2004, Regulatory Peptides.

[64]  Matthias P Lutolf,et al.  Biopolymeric delivery matrices for angiogenic growth factors. , 2003, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[65]  Timo Jämsä,et al.  Adenoviral VEGF‐A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues , 2003, The journal of gene medicine.

[66]  David J Mooney,et al.  Comparison of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in SCID mice. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[67]  H. Redmond,et al.  Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[68]  M. Laroche Intraosseous circulation from physiology to disease. , 2002, Joint, bone, spine : revue du rhumatisme.

[69]  S. Papapoulos,et al.  Bone Morphogenetic Proteins Stimulate Angiogenesis through Osteoblast-Derived Vascular Endothelial Growth Factor A. , 2002, Endocrinology.

[70]  A. Simpson,et al.  The vascularity of atrophic non-unions. , 2002, Injury.

[71]  O. Reikerås,et al.  Poor muscle coverage delays fracture healing in rats , 2002, Acta orthopaedica Scandinavica.

[72]  M. Schaffler,et al.  Prevention of fracture healing in rats by an inhibitor of angiogenesis. , 2001, Bone.

[73]  L. Bonassar,et al.  Replacement of an avulsed phalanx with tissue-engineered bone. , 2001, The New England journal of medicine.

[74]  Kozo Nakamura,et al.  Acceleration of fracture healing in nonhuman primates by fibroblast growth factor-2. , 2001, The Journal of clinical endocrinology and metabolism.

[75]  H. Blau,et al.  VEGF gene delivery to myocardium: deleterious effects of unregulated expression. , 2000, Circulation.

[76]  A. Parfitt The mechanism of coupling: a role for the vasculature. , 2000, Bone.

[77]  C H Turner,et al.  Three rules for bone adaptation to mechanical stimuli. , 1998, Bone.

[78]  A. Canfield,et al.  Vascular Pericytes Express Osteogenic Potential In Vitro and In Vivo , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  G. Gruden,et al.  Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[80]  James B. Hoying,et al.  Angiogenic potential of microvessel fragments established in three-dimensional collagen gels , 1996, In Vitro Cellular & Developmental Biology - Animal.

[81]  J. Vacanti,et al.  Femoral shaft reconstruction using tissue-engineered growth of bone. , 1996, International journal of oral and maxillofacial surgery.

[82]  C. Turner,et al.  Mechanotransduction and the functional response of bone to mechanical strain , 1995, Calcified Tissue International.

[83]  E R Draper,et al.  The vascular response to fracture micromovement. , 1994, Clinical orthopaedics and related research.

[84]  J Aronson,et al.  Temporal and spatial increases in blood flow during distraction osteogenesis. , 1994, Clinical orthopaedics and related research.

[85]  O. Reikerås,et al.  Blood flow and mechanical properties of healing bone. Femoral osteotomies studied in rats. , 1992, Acta orthopaedica Scandinavica.

[86]  Glenn Kc,et al.  Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. , 1988 .

[87]  J Kenwright,et al.  The influence of induced micromovement upon the healing of experimental tibial fractures. , 1985, The Journal of bone and joint surgery. British volume.

[88]  J. Niinikoski,et al.  Tissue oxygen tension in externally stabilized tibial fractures in rabbits during normal healing and infection. , 1984, The Journal of surgical research.

[89]  A Sarmiento,et al.  Fracture healing in rat femora as affected by functional weight-bearing. , 1977, The Journal of bone and joint surgery. American volume.

[90]  F. W. Rhinelander The normal microcirculation of diaphyseal cortex and its response to fracture. , 1968, The Journal of bone and joint surgery. American volume.

[91]  Stuart K Williams,et al.  Manipulating the microvasculature and its microenvironment. , 2013, Critical reviews in biomedical engineering.

[92]  Cato T Laurencin,et al.  Bone tissue engineering: recent advances and challenges. , 2012, Critical reviews in biomedical engineering.

[93]  J. Platt,et al.  Surgical angiogenesis: a new approach to maintain osseous viability in xenotransplantation , 2010, Xenotransplantation.

[94]  J. Hoying,et al.  Implanted microvessels progress through distinct neovascularization phenotypes. , 2010, Microvascular research.

[95]  Antonios G Mikos,et al.  Tissue engineering strategies for bone regeneration. , 2005, Advances in biochemical engineering/biotechnology.

[96]  Ranieri Cancedda,et al.  Bone Marrow Stromal Cells (BMSCs) in Bone Engineering: Limitations and Recent Advances , 2004, Annals of Biomedical Engineering.

[97]  Dietmar W Hutmacher,et al.  Periosteal cells in bone tissue engineering. , 2003, Tissue engineering.

[98]  K. Glenn,et al.  Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis. , 1988, Peptide research.

[99]  A. Weiland,et al.  Microvascular free bone transfer with revascularization of the medullary and periosteal circulation or the periosteal circulation alone. A comparative experimental study. , 1982, The Journal of bone and joint surgery. American volume.