EFFECT OF HUMAN GROWTH HORMONE ON MUSCLE AND ADIPOSE TISSUE METABOLISM IN THE FOREARM OF MAN.

Previous reports concerning the effects of human, bovine, and porcine growth hormone on carbohydrate and fat metabolism are disparate. Growth hormone has been variously stated to be without effect, to increase, to depress, and to have a biphasic action on glucose uptake of excised rat hemidiaphragm (1-5), on isolated perfused rat heart (6, 7), and on the blood glucose concentration of man and rat (8, 9). With respect to effects on fat metabolism, injection of growth hormone consistently provokes, within a matter of hours, a rise in plasma free fatty acids (FFA) (10, 11), but in those experiments where earlier effects have been looked for, an initial hypolipacidemia has been reported (12, 13). These observations have been difficult to reconcile with reports of poor or erratic lipolytic activity displayed by growth hormone preparations on excised rat adipose tissue (14). Much of the conflicting literature may arise from use of impure pituitary extracts, inadequate recognition of species specificity for growth hormones, and use of pharmacologic doses of the

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