Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein
暂无分享,去创建一个
R. Efremov | A. Sobolevsky | N. Krylov | Y. Trofimov | A. Neuberger | M. Yelshanskaya | K. Nadezhdin
[1] K. D. Nadezhdin,et al. Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine , 2022, Nature Communications.
[2] A. Sobolevsky,et al. Ligand-Binding Sites in Vanilloid-Subtype TRP Channels , 2022, Frontiers in Pharmacology.
[3] Vinayak Khattar,et al. Calcium Selective Channel TRPV6: Structure, Function, and Implications in Health and Disease. , 2022, Gene.
[4] K. D. Nadezhdin,et al. Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole , 2021, Nature Communications.
[5] E. Zakharian,et al. Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole , 2021, EMBO reports.
[6] U. Wissenbach,et al. Human TRPV6-pathies caused by gene mutations. , 2021, Biochimica et biophysica acta. General subjects.
[7] Zhuo-qin Jiang,et al. Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin , 2020, Food & nutrition research.
[8] C. Romanin,et al. Inactivation-mimicking block of the epithelial calcium channel TRPV6 , 2020, Science Advances.
[9] Anchi Cheng,et al. Leginon: New features and applications , 2020, Protein science : a publication of the Protein Society.
[10] Conrad C. Huang,et al. UCSF ChimeraX: Structure visualization for researchers, educators, and developers , 2020, Protein science : a publication of the Protein Society.
[11] M. Tominaga,et al. Novel TRPV6 mutations in the spectrum of transient neonatal hyperparathyroidism , 2020, The Journal of Physiological Sciences.
[12] Z. Liao,et al. TRPV6 variants confer susceptibility to chronic pancreatitis in the Chinese population , 2020, Human mutation.
[13] M. Saidijam,et al. Beneficial effects of genistein in suppression of proliferation, inhibition of metastasis, and induction of apoptosis in PC3 prostate cancer cells , 2020, Archives of physiology and biochemistry.
[14] R. Dahiya,et al. Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer. , 2020, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
[15] P. Bugert,et al. Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-onset Chronic Pancreatitis: TRPV6 and pancreatitis. , 2020, Gastroenterology.
[16] J. Stewart. TRPV6 as A Target for Cancer Therapy , 2020, Journal of Cancer.
[17] R. Holcombe,et al. Genistein combined with FOLFOX or FOLFOX–Bevacizumab for the treatment of metastatic colorectal cancer: phase I/II pilot study , 2019, Cancer Chemotherapy and Pharmacology.
[18] H. Mizumoto,et al. TRPV6 Gene Mutation in a Dizygous Twin With Transient Neonatal Hyperparathyroidism , 2019, Journal of the Endocrine Society.
[19] S. Ellard,et al. TRPV6 compound heterozygous variants result in impaired placental calcium transport and severe undermineralization and dysplasia of the fetal skeleton , 2018, American journal of medical genetics. Part A.
[20] E. C. Twomey,et al. Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6 , 2018, Science Advances.
[21] A. Sobolevsky,et al. Structural bases of TRP channel TRPV6 allosteric modulation by 2-APB , 2018, Nature Communications.
[22] M. Tominaga,et al. TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism. , 2018, American journal of human genetics.
[23] E. C. Twomey,et al. Opening of the Human Epithelial Calcium Channel TRPV6 , 2017, Nature.
[24] A. Sobolevsky,et al. Swapping of transmembrane domains in the epithelial calcium channel TRPV6 , 2017, Scientific Reports.
[25] D. Agard,et al. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy , 2017, Nature Methods.
[26] A. Sobolevsky,et al. Crystal Structure of the Epithelial Calcium Channel TRPV6 , 2016, Nature.
[27] Berk Hess,et al. GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers , 2015 .
[28] E. Gouaux,et al. Screening and large-scale expression of membrane proteins in mammalian cells for structural studies , 2014, Nature Protocols.
[29] A. Sobolevsky,et al. Structure of an agonist-bound ionotropic glutamate receptor , 2014, Science.
[30] R. Bergan,et al. Genistein inhibits human prostate cancer cell detachment, invasion, and metastasis. , 2014, The American journal of clinical nutrition.
[31] Jing Huang,et al. CHARMM36 all‐atom additive protein force field: Validation based on comparison to NMR data , 2013, J. Comput. Chem..
[32] Zhiwei Wang,et al. Genistein down-regulates miR-223 expression in pancreatic cancer cells. , 2013, Current drug targets.
[33] D. Cucinotta,et al. Genistein in the metabolic syndrome: results of a randomized clinical trial. , 2013, The Journal of clinical endocrinology and metabolism.
[34] J. Asplin,et al. Increased biological response to 1,25(OH)(2)D(3) in genetic hypercalciuric stone-forming rats. , 2013, American journal of physiology. Renal physiology.
[35] S. Scheres. RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.
[36] H. Masuno,et al. Genistein inhibits cell invasion and motility by inducing cell differentiation in murine osteosarcoma cell line LM8 , 2012, BMC Cell Biology.
[37] Alexander D. MacKerell,et al. Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles. , 2012, Journal of chemical theory and computation.
[38] Jeffery B. Klauda,et al. Improving the CHARMM force field for polyunsaturated fatty acid chains. , 2012, The journal of physical chemistry. B.
[39] Hongju Wu,et al. Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease. , 2012, American journal of physiology. Cell physiology.
[40] Wei Yang,et al. Modeling Structural Coordination and Ligand Binding in Zinc Proteins with a Polarizable Potential. , 2012, Journal of chemical theory and computation.
[41] E. Zakharian,et al. Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5)P2 , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[42] Shu-Wha Lin,et al. Generation and analysis of the thiazide‐sensitive Na+‐Cl− cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome , 2010, Human mutation.
[43] R. Bergan,et al. Inhibition of cancer cell invasion and metastasis by genistein , 2010, Cancer and Metastasis Reviews.
[44] Alexander D. MacKerell,et al. Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types. , 2010, The journal of physical chemistry. B.
[45] R. Priefer,et al. Novel Synthesis of theIsoflavone Genistein , 2010 .
[46] H. Weiler,et al. Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta , 2010, Journal of cellular and molecular medicine.
[47] Lennart Nilsson,et al. Ligand unbinding from the estrogen receptor: A computational study of pathways and ligand specificity , 2009, Proteins.
[48] Jun Wang,et al. Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV‐40 tag rats , 2009, The Prostate.
[49] Ximing J. Yang,et al. MEK4 function, genistein treatment, and invasion of human prostate cancer cells. , 2009, Journal of the National Cancer Institute.
[50] A. Runov,et al. Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells. , 2009, American journal of physiology. Cell physiology.
[51] Zhiwei Wang,et al. Multi-targeted therapy of cancer by genistein. , 2008, Cancer letters.
[52] G. Kollias,et al. Murine TNF&Dgr;ARE Crohn's disease model displays diminished expression of intestinal Ca2+ transporters , 2008, Inflammatory bowel diseases.
[53] Jamal Islam,et al. Poor Attitudes About Preparation, But What’s Good for Colonoscopy Is Not Good for Advanced Imaging , 2008 .
[54] E. Campbell,et al. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment , 2007, Nature.
[55] P. Wangemann,et al. Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. , 2007, American journal of physiology. Renal physiology.
[56] K. Griffith,et al. Genistein-induced apoptosis and autophagocytosis in ovarian cancer cells. , 2007, Gynecologic oncology.
[57] R. Bergan,et al. Genistein Inhibits Matrix Metalloproteinase Type 2 Activation and Prostate Cancer Cell Invasion by Blocking the Transforming Growth Factor β-Mediated Activation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-27-kDa Heat Shock Protein Pathway , 2006, Molecular Pharmacology.
[58] Anchi Cheng,et al. Automated molecular microscopy: the new Leginon system. , 2005, Journal of structural biology.
[59] Julian Tirado-Rives,et al. Potential energy functions for atomic-level simulations of water and organic and biomolecular systems. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[60] Quinn Lu,et al. Seamless cloning and gene fusion , 2005, Trends in Biotechnology.
[61] Zengli Yu,et al. Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells. , 2004, Cancer letters.
[62] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[63] Alexander D. MacKerell,et al. Improved treatment of the protein backbone in empirical force fields. , 2004, Journal of the American Chemical Society.
[64] V. Flockerzi,et al. Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression , 2003, Oncogene.
[65] Yiwei Li,et al. Inactivation of NF-κB by genistein is mediated via Akt signaling pathway in breast cancer cells , 2003, Oncogene.
[66] Shifeng Yu,et al. Genistein prevents bone resorption diseases by inhibiting bone resorption and stimulating bone formation. , 2003, Biological & pharmaceutical bulletin.
[67] B. Nilius,et al. Mg2+-dependent Gating and Strong Inward Rectification of the Cation Channel TRPV6 , 2003, The Journal of general physiology.
[68] Yiwei Li,et al. Gene expression profiles of genistein-treated PC3 prostate cancer cells. , 2002, The Journal of nutrition.
[69] P. Albertazzi. Purified phytoestrogens in postmenopausal bone health: is there a role for genistein? , 2002, Climacteric : the journal of the International Menopause Society.
[70] R. Vennekens,et al. Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1 , 2001, British journal of pharmacology.
[71] S. File,et al. Eating soya improves human memory , 2001, Psychopharmacology.
[72] E. Brown,et al. CaT1 expression correlates with tumor grade in prostate cancer. , 2001, Biochemical and biophysical research communications.
[73] J Pulokas,et al. Leginon: an automated system for acquisition of images from vitreous ice specimens. , 2000, Journal of structural biology.
[74] D. Alekel,et al. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. , 2000, The American journal of clinical nutrition.
[75] W. Banz,et al. A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. , 2000, The Journal of nutrition.
[76] A. Duncan,et al. Soy isoflavones improve plasma lipids in normocholesterolemic, premenopausal women. , 2000, The American journal of clinical nutrition.
[77] M. Hediger,et al. Molecular Cloning and Characterization of a Channel-like Transporter Mediating Intestinal Calcium Absorption* , 1999, The Journal of Biological Chemistry.
[78] J. Nyborg,et al. Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states. , 1999, Biochemistry.
[79] Jun Wang,et al. Dietary genistein: perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat. , 1998, Carcinogenesis.
[80] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[81] S. Barnes,et al. Prepubertal genistein exposure suppresses mammary cancer and enhances gland differentiation in rats. , 1996, Carcinogenesis.
[82] S. Barnes,et al. Genistein suppresses mammary cancer in rats. , 1995, Carcinogenesis.
[83] A. Burkhardt,et al. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases , 1995, Science.
[84] S. Barnes,et al. Neonatal Genistein Chemoprevents Mammary Cancer , 1995, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.
[85] E. Scholar,et al. Inhibition of invasion of murine mammary carcinoma cells by the tyrosine kinase inhibitor genistein. , 1994, Cancer letters.
[86] T. Darden,et al. Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems , 1993 .
[87] N. Day,et al. Dietary effects on breast-cancer risk in Singapore , 1991, The Lancet.
[88] E. D. Walter. Genistin (an Isoflavone Glucoside) and its Aglucone, Genistein, from Soybeans , 1941 .
[89] Z. Zhou,et al. Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM , 2017, Nature Structural & Molecular Biology.
[90] Ping Wang,et al. The sodium ion affinities of asparagine, glutamine, histidine and arginine , 2008 .
[91] A. Sevanian,et al. Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract. , 2001, Journal of agricultural and food chemistry.
[92] C. Riccardi,et al. Growth-inhibitory effects of the natural phyto-oestrogen genistein in MCF-7 human breast cancer cells. , 1994, European journal of cancer.