Relationship between medicine and stimulated saliva and oral moisture.

PURPOSE The aim of this study was to investigate the relationship between medicine and stimulated saliva and oral moisture. METHODS Fourteen patients with subjective oral dryness and 13 healthy adults were enrolled in this study. Disease, medicine, and medicines that had a side effect of oral dryness were investigated. The Saxon test was performed by chewing a piece of gauze sponge for 2 min. Oral moisture was measured at the lingual and buccal mucosa using an oral moisture checking device. Statistical analysis was performed by the Mann-Whitney U-test and Student t-test. RESULTS Stimulated saliva and oral moisture did not differ according to the number of diseases. Oral moisture at lingual mucosa was different between a minor medicine group (0-2 types of medicine) (31.3 +/- 1.9%) and a major medicine group (>or=3 types of medicine) (29.5 +/- 2.2%) (p = 0.05). Oral moisture differed between a group not taking any medicine that had a side effect of oral dryness (31.2 +/- 1.8% at lingual mucosa and 33.8 +/- 1.4% at buccal mucosa) and a group taking such medicine (29.3 +/- 2.3% at lingual mucosa and 32.4 +/- 1.8% at buccal mucosa) (p < 0.05). CONCLUSION The results of this study showed that oral moisture tended to decrease in the subjects who took many types of medicine or who took medicine that had a side effect of oral dryness. The medicine did not influence the amount of stimulated saliva. Therefore, it was suggested that medicine could influence the moisture of the oral mucosa.

[1]  K. Sawaki,et al.  [Adverse drug reactions and oral disorders]. , 2006, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[2]  Mutsumi Takahashi,et al.  Clinical Usefulness of an Oral Moisture Checking Device (Mucus , 2006 .

[3]  Linda Lee,et al.  Using the modified Schirmer test to measure mouth dryness: a preliminary study. , 2005, Journal of the American Dental Association.

[4]  C. Scully,et al.  Adverse drug reactions in the orofacial region. , 2004, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[5]  Fumi Takahashi,et al.  Evaluation of the Usability of Modified Saxon Test , 2003 .

[6]  C. S. Cbe.  Drug effects on salivary glands: dry mouth , 2003 .

[7]  A. Diaz-Arnold,et al.  The impact of saliva on patient care: A literature review. , 2002, The Journal of prosthetic dentistry.

[8]  M. Rosenberg,et al.  A simple technique for the determination of salivary gland hypofunction. , 2002, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[9]  T. Rees.  Drugs and oral disorders. , 1998, Periodontology 2000.

[10]  L. Sreebny,et al.  A reference guide to drugs and dry mouth--2nd edition. , 1997, Gerodontology.

[11]  J D Walter,et al.  New design for an artificial saliva reservoir for the mandibular complete denture. , 1996, The Journal of prosthetic dentistry.

[12]  R. E. Martin.  Management of dry mouth in elderly patients. , 1994, The Journal of the Greater Houston Dental Society.

[13]  A. P. Burtner,et al.  Oral side-effects of the most frequently prescribed drugs. , 1994, Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry.

[14]  W. Niedermeier,et al.  Salivary secretion and denture retention. , 1992, The Journal of prosthetic dentistry.

[15]  I. Mandel.  The role of saliva in maintaining oral homeostasis. , 1989, Journal of the American Dental Association.

[16]  L. Sreebny,et al.  Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. , 1988, Oral surgery, oral medicine, and oral pathology.

[17]  L. Sreebny,et al.  Xerostomia. A neglected symptom. , 1987, Archives of internal medicine.

[18]  L. Tabak,et al.  Saliva: a significant factor in removable prosthodontic treatment. , 1987, The Journal of prosthetic dentistry.

[19]  L. Sreebny,et al.  A reference guide to drugs and dry mouth. , 1986, Gerodontology.

[20]  P. Kohler,et al.  A quantitative test for xerostomia. The Saxon test, an oral equivalent of the Schirmer test. , 1985, Arthritis and rheumatism.

[21]  B. Sonies,et al.  Xerostomia: evaluation of a symptom with increasing significance. , 1985, Journal of the American Dental Association.