p53 mRNA controls p53 activity by managing Mdm2 functions

[1]  R. Fåhraeus,et al.  Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation , 2006, Oncogene.

[2]  Stanley N Cohen,et al.  Human MDM2 Isoforms Translated Differentially on Constitutive versus p53-Regulated Transcripts Have Distinct Functions in the p53/MDM2 and TSG101/MDM2 Feedback Control Loops , 2006, Molecular and Cellular Biology.

[3]  R. Grover,et al.  Two internal ribosome entry sites mediate the translation of p53 isoforms , 2006, EMBO reports.

[4]  R. Hay,et al.  Detection of modification by ubiquitin-like proteins. , 2006, Methods.

[5]  R. Fåhraeus.  Do peptides control their own birth and death? , 2005, Nature Reviews Molecular Cell Biology.

[6]  Hong Yang,et al.  Phosphorylation of p53 on Key Serines Is Dispensable for Transcriptional Activation and Apoptosis*♦ , 2004, Journal of Biological Chemistry.

[7]  Wei-jun Ma,et al.  A modified quantitative EMSA and its application in the study of RNA--protein interactions. , 2004, Journal of biochemical and biophysical methods.

[8]  Chris M. Brown,et al.  Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs , 2004, The EMBO journal.

[9]  M. E. Perry.  Mdm2 in the response to radiation. , 2004, Molecular cancer research : MCR.

[10]  Jerson L. Silva,et al.  Mutations in the hydrophobic core and in the protein-RNA interface affect the packing and stability of icosahedral viruses. , 2003, European journal of biochemistry.

[11]  D. Oscier,et al.  Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors. , 2002, Blood.

[12]  Yili Yin,et al.  p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products , 2002, Nature Cell Biology.

[13]  S. Tenenbaum,et al.  Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays. , 2002, Methods.

[14]  Takeharu Nagai,et al.  Shift anticipated in DNA microarray market , 2002, Nature Biotechnology.

[15]  A. Levine,et al.  The p53 functional circuit. , 2001, Journal of cell science.

[16]  Shengyun Fang,et al.  Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53* , 2000, The Journal of Biological Chemistry.

[17]  D. Meek,et al.  Serine 15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2 , 1999, The EMBO journal.

[18]  R. Hay,et al.  SUMO‐1 modification activates the transcriptional response of p53 , 1999, The EMBO journal.

[19]  P. Howley,et al.  Mutations in serines 15 and 20 of human p53 impair its apoptotic activity , 1999, Oncogene.

[20]  J. Sabina,et al.  Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. , 1999, Journal of molecular biology.

[21]  R. Hofstra,et al.  Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue. , 1999, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

[22]  Xinbin Chen,et al.  Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis* , 1998, The Journal of Biological Chemistry.

[23]  Hirofumi Tanaka,et al.  Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 , 1997, FEBS letters.

[24]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[25]  M. Oren,et al.  Mdm2 promotes the rapid degradation of p53 , 1997, Nature.

[26]  A. Levine,et al.  Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain , 1996, Science.

[27]  A. Levine,et al.  The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain , 1996, Molecular medicine.

[28]  M. Spitz,et al.  p53 mutations in nonmelanoma skin cancer of the head and neck: molecular evidence for field cancerization. , 1995, Cancer research.

[29]  C Haanen,et al.  A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. , 1995, Journal of immunological methods.

[30]  A. Levine,et al.  The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes , 1994, Molecular and cellular biology.

[31]  M. Oren,et al.  Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. , 1993, Oncogene.