Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.

[1]  Mustafa Sarimollaoglu,et al.  Real‐time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry , 2014, Head & neck.

[2]  S. Isom,et al.  Src‐dependent Tks5 phosphorylation regulates invadopodia‐associated invasion in prostate cancer cells , 2014, The Prostate.

[3]  Alissa M. Weaver,et al.  Exosome secretion is enhanced by invadopodia and drives invasive behavior. , 2013, Cell reports.

[4]  J. Condeelis,et al.  Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells , 2013, Current Biology.

[5]  J. Condeelis,et al.  Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation , 2013, Oncogene.

[6]  Jason V. Evans,et al.  Src binds cortactin through an SH2 domain cystine-mediated linkage , 2012, Journal of Cell Science.

[7]  C. Turner,et al.  Hic-5 promotes invadopodia formation and invasion during TGF-b–induced epithelial–mesenchymal transition , 2012 .

[8]  C. Turner,et al.  Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition , 2012, The Journal of cell biology.

[9]  R. Bose,et al.  Identification of Targets of c-Src Tyrosine Kinase by Chemical Complementation and Phosphoproteomics* , 2012, Molecular & Cellular Proteomics.

[10]  J. Condeelis,et al.  N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors , 2012, Journal of Cell Science.

[11]  T. Wandless,et al.  Imaging the Impact of Chemically Inducible Proteins on Cellular Dynamics In Vivo , 2012, PloS one.

[12]  D. Larson,et al.  Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway , 2011, The Journal of cell biology.

[13]  Alissa M. Weaver,et al.  Cortactin Controls Cell Motility and Lamellipodial Dynamics by Regulating ECM Secretion , 2011, Current Biology.

[14]  Y. Kawakami,et al.  A Src-Tks5 Pathway Is Required for Neural Crest Cell Migration during Embryonic Development , 2011, PloS one.

[15]  T. Mak,et al.  The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk , 2011, Oncogene.

[16]  S. Courtneidge,et al.  The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function , 2011, Nature Reviews Molecular Cell Biology.

[17]  V. Giguère,et al.  Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis , 2011, Laboratory Investigation.

[18]  Thinzar M. Lwin,et al.  Twist1-induced invadopodia formation promotes tumor metastasis. , 2011, Cancer cell.

[19]  J. Condeelis,et al.  An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. , 2011, Cancer research.

[20]  J. Condeelis,et al.  Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia , 2010, Journal of Cell Science.

[21]  Nicole F Steinmetz,et al.  Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles , 2010, Nature Protocols.

[22]  Jing Yang,et al.  Visualizing extravasation dynamics of metastatic tumor cells , 2010, Journal of Cell Science.

[23]  Robert D. Goldman,et al.  Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia , 2010, The Journal of cell biology.

[24]  G. Condorelli,et al.  MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro , 2010, The Journal of cell biology.

[25]  Diana Anderson,et al.  Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation , 2009, Science Signaling.

[26]  Jacco van Rheenen,et al.  Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation , 2009, The Journal of cell biology.

[27]  G. Beznoussenko,et al.  Invadopodia biogenesis is regulated by caveolin‐mediated modulation of membrane cholesterol levels , 2009, Journal of cellular and molecular medicine.

[28]  I. Pass,et al.  The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation. , 2009, Molecular biology of the cell.

[29]  Jacco van Rheenen,et al.  Intravital imaging of metastatic behavior through a mammary imaging window , 2008, Nature Methods.

[30]  James P. Quigley,et al.  Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis , 2008, Histochemistry and Cell Biology.

[31]  C. Carman,et al.  Trans-cellular migration: cell-cell contacts get intimate. , 2008, Current opinion in cell biology.

[32]  I. Pass,et al.  A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo. , 2008, European journal of cell biology.

[33]  J. Lewis,et al.  The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. , 2008, Cancer cell.

[34]  R. Geha,et al.  Transcellular diapedesis is initiated by invasive podosomes. , 2007, Immunity.

[35]  D. Maurice,et al.  Formation of Extracellular Matrix-Digesting Invadopodia by Primary Aortic Smooth Muscle Cells , 2007, Circulation research.

[36]  Alissa M. Weaver,et al.  Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. , 2007, Cancer research.

[37]  S. Linder The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. , 2007, Trends in cell biology.

[38]  K. Yamauchi,et al.  Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. , 2006, Cancer research.

[39]  Françoise Seillier-Moiseiwitsch,et al.  Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. , 2006, Cancer research.

[40]  J. Resau,et al.  The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. , 2005, Cancer cell.

[41]  C. Carman,et al.  A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them , 2004, The Journal of cell biology.

[42]  A. Giuliano,et al.  Manipulation of the primary breast tumor and the incidence of sentinel node metastases from invasive breast cancer. , 2004, Archives of surgery.

[43]  I. Pass,et al.  The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells* , 2003, The Journal of Biological Chemistry.

[44]  Jackelyn A. Alva,et al.  Selective Binding of Lectins to Embryonic Chicken Vasculature , 2003, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[45]  Alissa M. Weaver,et al.  Interaction of Cortactin and N-WASp with Arp2/3 Complex , 2002, Current Biology.

[46]  I. Macdonald,et al.  Metastasis: Dissemination and growth of cancer cells in metastatic sites , 2002, Nature Reviews Cancer.

[47]  R. Khokha,et al.  Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Y. Oshika,et al.  P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo. , 1996, British Journal of Cancer.

[49]  J. Chin,et al.  Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. , 2014, Cancer research.

[50]  J. Condeelis,et al.  High-resolution live-cell imaging and time-lapse microscopy of invadopodium dynamics and tracking analysis. , 2013, Methods in molecular biology.

[51]  Alissa M. Weaver,et al.  Synthetic and tissue-derived models for studying rigidity effects on invadopodia activity. , 2013, Methods in molecular biology.

[52]  A. Chambers,et al.  Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging. , 2012, Methods in molecular biology.

[53]  A. Chambers,et al.  A New Model for Lymphatic Metastasis: Development of a Variant of the MDA-MB-468 Human Breast Cancer Cell Line that Aggressively Metastasizes to Lymph Nodes , 2005, Clinical and Experimental Metastasis.