Treatment of primary HIV‐1 infection with nonnucleoside reverse transcriptase inhibitor‐based therapy is effective and well tolerated

Objectives Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV‐1 infection. We investigated the use of a nonnucleoside reverse transcriptase inhibitor (NNRTI)‐based regimen in this setting.

[1]  John W. Mellors,et al.  Predictive Value of Immunologic and Virologic Markers After Long or Short Duration of HIV‐1 Infection , 2002, Journal of acquired immune deficiency syndromes.

[2]  R. Paredes,et al.  Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  Mardge H. Cohen,et al.  Determinants of HIV-1 shedding in the genital tract of women , 2001, The Lancet.

[4]  M. Altfeld,et al.  Less is more? STI in acute and chronic HIV-1 infection , 2001, Nature Medicine.

[5]  S. De Wit.  Commentary on the summary of the French Guidelines for the treatment of HIV‐infected adults with antiretroviral therapy , 2000, HIV medicine.

[6]  A. Landay,et al.  Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease , 2000, AIDS.

[7]  P. Easterbrook,et al.  Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. Moore,et al.  The effect of commencing combination antiretroviral therapy soon after human immunodeficiency virus type 1 infection on viral replication and antiviral immune responses. , 1999, The Journal of infectious diseases.

[9]  B. Gazzard,et al.  1998 revision to the British HIV Association guidelines for antiretroviral treatment of HIV seropositive individuals , 1998, The Lancet.

[10]  G. Satten,et al.  Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. , 1998, The New England journal of medicine.

[11]  J. Mellors,et al.  Quantitation of HIV-1 RNA in Plasma Predicts Outcome after Seroconversion , 1995, Annals of Internal Medicine.