Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healing

[1]  A. Nicholson,et al.  Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. , 2009, The Journal of clinical investigation.

[2]  M. Nilsen-Hamilton,et al.  α3β1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3 , 2009, Journal of Cell Science.

[3]  H. Larjava,et al.  Mice lacking β6 integrin in skin show accelerated wound repair in dexamethasone impaired wound healing model , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[4]  P. Weinreb,et al.  Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). , 2009, The American journal of pathology.

[5]  G. Giannelli,et al.  Targeting transforming growth factor (TGF)‐βRI inhibits activation of β1 integrin and blocks vascular invasion in hepatocellular carcinoma , 2009, Hepatology.

[6]  R. Fässler,et al.  Genetic and cell biological analysis of integrin outside-in signaling. , 2009, Genes & development.

[7]  H. Chapman,et al.  Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts , 2009, The Journal of cell biology.

[8]  A. Sonnenberg,et al.  Integrin α3β1 inhibits directional migration and wound re-epithelialization in the skin , 2009, Journal of Cell Science.

[9]  A. Pozzi,et al.  Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. , 2009, Cancer research.

[10]  P. Weinreb,et al.  Mice that lack activity of αvβ6- and αvβ8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice , 2009, Journal of Cell Science.

[11]  P. Wolters,et al.  Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. , 2008, The Journal of clinical investigation.

[12]  B. Hinz,et al.  Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship. , 2008, European journal of cell biology.

[13]  D. Schuppan,et al.  Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. , 2008, Gastroenterology.

[14]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

[15]  G. Thomas,et al.  alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. , 2008, Cancer research.

[16]  T. Sawada,et al.  A Novel Transforming Growth Factor β Receptor Kinase Inhibitor, A-77, Prevents the Peritoneal Dissemination of Scirrhous Gastric Carcinoma , 2008, Clinical Cancer Research.

[17]  P. Thompson,et al.  Transforming Growth Factor β1 Induces αvβ3 Integrin Expression in Human Lung Fibroblasts via a β3 Integrin-, c-Src-, and p38 MAPK-dependent Pathway* , 2008, Journal of Biological Chemistry.

[18]  Vandana Iyer,et al.  alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. , 2008, The Journal of clinical investigation.

[19]  Vandana Iyer,et al.  Integrin α3β1 potentiates TGFβ-mediated induction of MMP-9 in immortalized keratinocytes , 2008 .

[20]  A. Gown,et al.  Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. , 2008, Cancer research.

[21]  B. Hinz,et al.  Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix , 2007, The Journal of cell biology.

[22]  H. Schnaper,et al.  MAP-kinase activity necessary for TGFβ1-stimulated mesangial cell type I collagen expression requires adhesion-dependent phosphorylation of FAK tyrosine 397 , 2007, Journal of Cell Science.

[23]  Yuanyuan Xiao,et al.  Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. , 2007, The Journal of clinical investigation.

[24]  P. Weinreb,et al.  Role of αvβ6 integrin in acute biliary fibrosis , 2007 .

[25]  E. Fuchs,et al.  Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. , 2007, Cancer cell.

[26]  J. Roes,et al.  Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins , 2007, Proceedings of the National Academy of Sciences.

[27]  J. Bluestone,et al.  Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice , 2007 .

[28]  A. Gorter,et al.  Overexpression of the αvβ6 integrin in cervical squamous cell carcinoma is a prognostic factor for decreased survival , 2007 .

[29]  D. Greenhalgh,et al.  Cutaneous Wound Healing , 2007, Journal of burn care & research : official publication of the American Burn Association.

[30]  Zhiwei Yang,et al.  Absence of integrin-mediated TGFβ1 activation in vivo recapitulates the phenotype of TGFβ1-null mice , 2007, The Journal of cell biology.

[31]  D. Sheppard,et al.  Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix , 2006, Proceedings of the National Academy of Sciences.

[32]  M. Jinnin,et al.  Involvement of αvβ5 Integrin in the Establishment of Autocrine TGF-β Signaling in Dermal Fibroblasts Derived from Localized Scleroderma , 2006 .

[33]  J. Araya,et al.  Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. , 2006, The American journal of pathology.

[34]  William P Schiemann,et al.  β3 Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cells , 2006, Breast Cancer Research.

[35]  Xiu-fen Lei,et al.  Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. , 2006, Cancer research.

[36]  Brian Bierie,et al.  Tumour microenvironment: TGFβ: the molecular Jekyll and Hyde of cancer , 2006, Nature Reviews Cancer.

[37]  R. Chambers,et al.  Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. , 2006, The Journal of clinical investigation.

[38]  H. Larjava,et al.  The αvβ6 integrin plays a role in compromised epidermal wound healing , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[39]  D. Sheppard,et al.  Activation of Transforming Growth Factor- by the Integrin v8 Delays Epithelial Wound Closure , 2006 .

[40]  M. Jinnin,et al.  Increased Expression of Integrin αvβ5 Induces the Myofibroblastic Differentiation of Dermal Fibroblasts , 2006 .

[41]  M. Jinnin,et al.  Increased Expression of Integrin αvβ3 Contributes to the Establishment of Autocrine TGF-β Signaling in Scleroderma Fibroblasts1 , 2005, The Journal of Immunology.

[42]  D. Rifkin,et al.  Fibronectin is required for integrin o:vβ6‐mediated activation of latent TGF‐β complexes containing LTBP‐1 , 2005 .

[43]  M. Jinnin,et al.  Involvement of αvβ5 integrin–mediated activation of latent transforming growth factor β1 in autocrine transforming growth factor β signaling in systemic sclerosis fibroblasts , 2005 .

[44]  P. Oettgen,et al.  Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. , 2005, The Journal of clinical investigation.

[45]  R. Hynes,et al.  Accelerated re-epithelialization in β3-integrin-deficient- mice is associated with enhanced TGF-β1 signaling , 2005, Nature Medicine.

[46]  A. Ghahary,et al.  Transforming growth factor‐β and its effect on reepithelialization of partial‐thickness ear wounds in transgenic mice , 2005, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[47]  P. Thompson,et al.  αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts* , 2004, Journal of Biological Chemistry.

[48]  D. Rifkin,et al.  Integrin αVβ6-mediated activation of latent TGF-β requires the latent TGF-β binding protein-1 , 2004, The Journal of cell biology.

[49]  A. Roberts,et al.  Full‐thickness wounding of the mouse tail as a model for delayed wound healing: accelerated wound closure in Smad3 knock‐out mice , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[50]  D. Sheppard,et al.  Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice , 2003 .

[51]  F. Watt,et al.  Suprabasal α6β4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFβ signalling , 2003, Journal of Cell Science.

[52]  Junwei Yang,et al.  Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis , 2003 .

[53]  D. Jablons,et al.  Integrin (cid:1) v (cid:2) 8-Mediated Activation of Transforming Growth Factor- (cid:2) Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue , 2022 .

[54]  A. Saven,et al.  Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[55]  S. Werner,et al.  Regulation of wound healing by growth factors and cytokines. , 2003, Physiological reviews.

[56]  Alan Morgan,et al.  Secretory granule exocytosis. , 2003, Physiological reviews.

[57]  S. Barry,et al.  The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3. , 2003, The Biochemical journal.

[58]  L. Schnapp,et al.  Integrin α8β1 mediates adhesion to LAP-TGFβ1 , 2002, Journal of Cell Science.

[59]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[60]  P. Schirmacher,et al.  Resistance of keratinocytes to TGFbeta-mediated growth restriction and apoptosis induction accelerates re-epithelialization in skin wounds. , 2002, Journal of cell science.

[61]  Sabine Werner,et al.  A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair. , 2002, Development.

[62]  A. Ghahary,et al.  Development, characterization, and wound healing of the keratin 14 promoted transforming growth factor‐β1 transgenic mouse , 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[63]  D. Sheppard,et al.  The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1 , 2002, The Journal of cell biology.

[64]  H. Moses,et al.  Integrin (cid:1) 1 Signaling Is Necessary for Transforming Growth Factor- (cid:1) Activation of p38MAPK and Epithelial Plasticity* , 2022 .

[65]  A. Ghahary,et al.  Healing of burn wounds in transgenic mice overexpressing transforming growth factor-beta 1 in the epidermis. , 2001, The American journal of pathology.

[66]  J. Massagué,et al.  Controlling TGF-β signaling , 2000, Genes & Development.

[67]  Robert V Farese,et al.  Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice , 2000, Molecular and Cellular Biology.

[68]  Anita B. Roberts,et al.  Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response , 1999, Nature Cell Biology.

[69]  Luzhe Sun,et al.  Control of Type II Transforming Growth Factor-β Receptor Expression by Integrin Ligation* , 1999, The Journal of Biological Chemistry.

[70]  N. Kaminski,et al.  The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. , 1999, Cell.

[71]  R. Hynes,et al.  Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. , 1999, The Journal of clinical investigation.

[72]  W. Stetler-Stevenson,et al.  Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3 , 1996, Cell.

[73]  Robert V Farese,et al.  Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin , 1996, The Journal of cell biology.

[74]  Nicola J. Rinaldi,et al.  Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation , 2008 .

[75]  P. Weinreb,et al.  Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis , 2008 .

[76]  川尻 成美.  A novel transforming growth factor β receptor kinase inhibitor, A-77, prevents the peritoneal dissemination of scirrhous gastric carcinoma , 2008 .

[77]  G. Thomas,et al.  A v B 6 Integrin Promotes the Invasion of Morphoeic Basal Cell Carcinoma through Stromal Modulation , 2008 .

[78]  K. Simon,et al.  Epithelial and Mesenchymal Cell Biology v 6 Integrin Regulates Renal Fibrosis and Inflammation in Alport Mouse , 2006 .

[79]  H. Larjava,et al.  Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds. , 2004, The American journal of pathology.

[80]  D. Taverna,et al.  Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins , 2002, Nature Medicine.

[81]  J. Munger.  The integrin αvβ6 binds and activates latent TGFβ1 : A mechanism for regulating pulmonary inflammation and fibrosis , 1999 .

[82]  W. Stetler-Stevenson,et al.  Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. , 1996, Cell.

[83]  S. Barry,et al.  The integrin αvβ3 is a receptor for the latency-associated peptides of transforming growth factors β1 and β3 , 2022 .