MAPS - A Magic Angle Positioning System for Enhanced Imaging in High-Field Small-Bore MRI

The "magic angle" MRI effect can enhance signal intensity in aligned collagenous structures oriented at approximately 55° with respect to the main magnetic field. The difficulty of positioning tissue inside closed-bore scanners has hampered magic angle use in research and clinics. An MRI-conditional mechatronic system has been developed to control sample orientation inside a 9.4T small bore MRI scanner. The system orients samples to within 0.5° and enables a 600% increase in tendon signal intensity.

[1]  B L Davies,et al.  A magnetic-resonance-compatible limb-positioning device to facilitate magic angle experiments in vivo , 2008, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[2]  J. Schenck The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. , 1996, Medical physics.

[3]  G. Fullerton,et al.  Orientation of tendons in the magnetic field and its effect on T2 relaxation times. , 1985, Radiology.

[4]  M Lampérth,et al.  A Review of Magnetic Resonance Imaging Compatible Manipulators in Surgery , 2006, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[5]  S. Erickson,et al.  The "magic angle" effect: background physics and clinical relevance. , 1993, Radiology.

[6]  E. Chang,et al.  Effects of achilles tendon immersion in saline and perfluorochemicals on T2 and T2* , 2014, Journal of magnetic resonance imaging : JMRI.

[7]  Ian Young,et al.  A MR Compatible Mechatronic System to Facilitate Magic Angle Experiments in Vivo , 2007, MICCAI.

[8]  Y. Xia,et al.  Magic-Angle Effect in Magnetic Resonance Imaging of Articular Cartilage: A Review , 2000, Investigative radiology.

[9]  Nobuhiko Hata,et al.  MR Compatible Surgical Assist Robot: System Integration and Preliminary Feasibility Study , 2000, MICCAI.

[10]  S. Arnoczky,et al.  Effect of cyclic and static tensile loading on water content and solute diffusion in canine flexor tendons: An in Vitro study , 1994, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[12]  L. Soslowsky,et al.  Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[13]  A. Viidik,et al.  Light and electron microscopic studies of collagen fibers under strain , 2004, Zeitschrift für Anatomie und Entwicklungsgeschichte.

[14]  Frank G Shellock,et al.  Magnetic resonance safety update 2002: Implants and devices , 2002, Journal of magnetic resonance imaging : JMRI.

[15]  Ron Kikinis,et al.  MR Compatibility of Mechatronic Devices: Design Criteria , 1999, MICCAI.

[16]  F G Shellock,et al.  Metallic surgical instruments for interventional MRI procedures: Evaluation of MR safety , 2001, Journal of magnetic resonance imaging : JMRI.

[17]  Akio Yamamoto,et al.  Actuation Methods for Applications in MR Environments , 2006 .

[18]  Kevin C. Chan,et al.  Multidisciplinary Ophthalmic Imaging Magic Angle – Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading , 2014 .

[19]  J. Matyas,et al.  The functional microstructure of tendon collagen revealed by high‐field MRI , 2011, Magnetic resonance in medicine.

[20]  Yang Xia,et al.  Molecular origin of a loading‐induced black layer in the deep region of articular cartilage at the magic angle , 2015, Journal of magnetic resonance imaging : JMRI.

[21]  C. Kremser,et al.  Metallic Artifacts in Magnetic Resonance Imaging of Patients With Spinal Fusion: A Comparison of Implant Materials and Imaging Sequences , 1998, Spine.

[22]  Fritz Schick,et al.  Whole-body MRI at high field: technical limits and clinical potential , 2005, European Radiology.

[23]  Henry Eyring,et al.  The Mechanical Properties of Rat Tail Tendon , 1959, The Journal of general physiology.

[24]  Zion Tsz Ho Tse,et al.  The case for MR‐compatible robotics: a review of the state of the art , 2008, The international journal of medical robotics + computer assisted surgery : MRCAS.

[25]  M.U. Lamperth,et al.  A 3-DOF MR-Compatible Device for Magic Angle Related In Vivo Experiments , 2008, IEEE/ASME Transactions on Mechatronics.

[26]  Constantinos Mavroidis,et al.  Magnetic resonance-compatible robotic and mechatronics systems for image-guided interventions and rehabilitation: a review study. , 2007, Annual review of biomedical engineering.