gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.
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Ozge Canli | Thomas Kirchner | Matthias Ernst | F. Greten | R. Schmid | V. Matthews | T. Kirchner | T. Putoczki | Roland M Schmid | Tracy Putoczki | Vance Matthews | T. Phesse | S. Schwitalla | M. Ernst | Julia Bollrath | J. Bollrath | Sarah Schwitalla | Toby J Phesse | Vivian A von Burstin | Moritz Bennecke | Trudie Bateman | Tim Nebelsiek | Therese Lundgren-May | Melek C Arkan | Florian R Greten | Vivian A. von Burstin | M. C. Arkan | Therese Lundgren-May | Tim Nebelsiek | Ozge Canli | Moritz Bennecke | Trudie Bateman | Tracy L. Putoczki
[1] M. Karin,et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. , 2009, Cancer cell.
[2] P. Musiani,et al. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. , 2004, Cytokine.
[3] K. Lim,et al. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. , 2007, Genes & development.
[4] R. Kiesslich,et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. , 2004, Immunity.
[5] W. Alexander,et al. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon , 2007, Oncogene.
[6] T. Tiganis,et al. DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. , 2008, Cancer cell.
[7] E. Grzesiuk,et al. Heat shock response in gastrointestinal tract. , 2007, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[8] S. Sa,et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens , 2008, Nature Medicine.
[9] K. Kinzler,et al. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T , 2007, Proceedings of the National Academy of Sciences.
[10] J. Turkson,et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. , 2003, Cancer research.
[11] K. Kiguchi,et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. , 2004, The Journal of clinical investigation.
[12] P. Guillou,et al. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family , 2000, British Journal of Cancer.
[13] B. Jenkins,et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice , 2002, Nature Medicine.
[14] R. Medzhitov,et al. Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88 , 2007, Science.
[15] Hua Yu,et al. The STATs of cancer — new molecular targets come of age , 2004, Nature Reviews Cancer.
[16] Xin-Yun Huang,et al. Identification of Novel Direct Stat3 Target Genes for Control of Growth and Differentiation* , 2008, Journal of Biological Chemistry.
[17] B. Groner,et al. The function of Stat3 in tumor cells and their microenvironment. , 2008, Seminars in cell & developmental biology.
[18] S. Akira,et al. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. , 1998, Journal of immunology.
[19] D. Hanahan,et al. The Hallmarks of Cancer , 2000, Cell.
[20] M. Karin,et al. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. , 2008, Trends in molecular medicine.
[21] S. Akira,et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. , 2006, Genes & development.
[22] Yihui Deng,et al. Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma , 2008, European Archives of Oto-Rhino-Laryngology.
[23] Hua Yu,et al. Tumour immunology: Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment , 2007, Nature Reviews Immunology.
[24] C. Rödel,et al. Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. , 2005, Cancer research.
[25] Biao He,et al. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[26] T. Nheu,et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling , 2005, Nature Medicine.
[27] W. Alexander,et al. General Nature of the STAT3-Activated Anti-Inflammatory Response1 , 2006, The Journal of Immunology.
[28] P. Heinrich,et al. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.
[29] J. Darnell,et al. Validating Stat3 in cancer therapy , 2005, Nature Medicine.
[30] D. Saur,et al. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. , 2007, The Journal of clinical investigation.
[31] O. Sansom,et al. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis , 2007, The Journal of cell biology.
[32] Michael Karin,et al. NF-kappaB: linking inflammation and immunity to cancer development and progression. , 2005, Nature reviews. Immunology.
[33] J. Turkson,et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. , 1999, Immunity.
[34] J. Davis,et al. Interleukin-6 and cachexia in ApcMin/+ mice. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.
[35] J. Gu,et al. JSI-124 inhibits glioblastoma multiforme cell proliferation through G2/M cell cycle arrest and apoptosis augmentation , 2008, Cancer biology & therapy.
[36] G. Sobue,et al. Genetic Evidence for a Protective Role for Heat Shock Factor 1 and Heat Shock Protein 70 against Colitis* , 2007, Journal of Biological Chemistry.
[37] J. Darnell,et al. Signalling: STATs: transcriptional control and biological impact , 2002, Nature Reviews Molecular Cell Biology.
[38] P. Allavena,et al. Cancer-related inflammation , 2008, Nature.
[39] W. Gerald,et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. , 2007, The Journal of clinical investigation.
[40] S. Akira,et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. , 1999, Immunity.
[41] D. Altieri. Survivin, cancer networks and pathway-directed drug discovery , 2008, Nature Reviews Cancer.
[42] B. Jenkins,et al. STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. , 2006, Gastroenterology.
[43] M. Leach,et al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. , 1996, The Journal of clinical investigation.
[44] Fengzhi Li,et al. Control of apoptosis and mitotic spindle checkpoint by survivin , 1998, Nature.
[45] J. Karras,et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. , 2008, Journal of Clinical Investigation.
[46] M. Karin,et al. Opposing functions of IKKβ during acute and chronic intestinal inflammation , 2008, Proceedings of the National Academy of Sciences.
[47] Stefan Wirtz,et al. TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling , 2004 .
[48] D. Gumucio,et al. cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine* , 2002, The Journal of Biological Chemistry.
[49] Hui Zhang,et al. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[50] R. Xavier,et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. , 2008, The Journal of clinical investigation.
[51] U. Klingmüller,et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. , 2006, Molecular biology of the cell.
[52] D. Hommes,et al. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease , 2007, Inflammatory bowel diseases.