Deubiquitinase PSMD14 Enhances Hepatocellular Carcinoma Growth and Metastasis by Stabilizing GRB2.

[1]  Yun Liu,et al.  POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1 , 2019, EBioMedicine.

[2]  T. Thanabalu,et al.  Overexpression of GRB2 Enhances Epithelial to Mesenchymal Transition of A549 Cells by Upregulating SNAIL Expression , 2018, Cells.

[3]  Zhihua Liu,et al.  Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma. , 2018, Cancer letters.

[4]  J. Yun,et al.  POH1 Knockdown Induces Cancer Cell Apoptosis via p53 and Bim , 2018, Neoplasia.

[5]  A. Befeler,et al.  Hepatocellular Carcinoma with Bone Metastases: Incidence, Prognostic Significance, and Management—Single-Center Experience , 2017, Journal of Gastrointestinal Cancer.

[6]  A. Borczuk,et al.  MET–GRB2 Signaling-Associated Complexes Correlate with Oncogenic MET Signaling and Sensitivity to MET Kinase Inhibitors , 2017, Clinical Cancer Research.

[7]  Changsheng Ye,et al.  RPN11 deubiquitinase promotes proliferation and migration of breast cancer cells. , 2017, Molecular medicine reports.

[8]  J. Qi,et al.  Blockade of deubiquitylating enzyme Rpn11 triggers apoptosis in multiple myeloma cells and overcomes bortezomib resistance , 2017, Oncogene.

[9]  J. Rowe,et al.  Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis , 2017, Journal of carcinogenesis.

[10]  Seth M. Cohen,et al.  Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. , 2017, Nature chemical biology.

[11]  Seth M. Cohen,et al.  Discovery of an Inhibitor of the Proteasome Subunit Rpn11. , 2017, Journal of medicinal chemistry.

[12]  A. Jemal,et al.  Cancer treatment and survivorship statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[13]  G. Mills,et al.  Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer , 2016, Oncogene.

[14]  Q. Xia,et al.  POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation , 2015, Nature Communications.

[15]  A. Piecuch,et al.  The role of Snail1 transcription factor in colorectal cancer progression and metastasis , 2015, Contemporary oncology.

[16]  B. Bonavida,et al.  Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention , 2014, Journal of experimental & clinical cancer research : CR.

[17]  T. Yao,et al.  Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. , 2013, Molecular cell.

[18]  Yue Zhuo,et al.  Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2 , 2013, Nature Communications.

[19]  K. Hochedlinger,et al.  Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. , 2012, Cell stem cell.

[20]  F. Festy,et al.  The proteasomal de‐ubiquitinating enzyme POH1 promotes the double‐strand DNA break response , 2012, The EMBO journal.

[21]  A. Hata,et al.  Targeting the TGFβ signalling pathway in disease , 2012, Nature Reviews Drug Discovery.

[22]  Jun Yao,et al.  G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. , 2012, The Journal of clinical investigation.

[23]  X. Bian,et al.  EZH2 supports nasopharyngeal carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1/HDAC2 and Snail to inhibit E-cadherin , 2012, Oncogene.

[24]  E. Jensen,et al.  The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts , 2010, Journal of cellular biochemistry.

[25]  K. Klinger,et al.  Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence. , 2010, Experimental cell research.

[26]  Cheng-rong Li,et al.  Relationship between expression of Pad1 homologue and multidrug resistance of idiopathic nephrotic syndrome , 2009, Pediatrics international : official journal of the Japan Pediatric Society.

[27]  G. Superti-Furga,et al.  Charting the molecular network of the drug target Bcr-Abl , 2009, Proceedings of the National Academy of Sciences.

[28]  T. Burke,et al.  Grb2 signaling in cell motility and cancer , 2008, Expert opinion on therapeutic targets.

[29]  M. Rolfe,et al.  The JAMM motif of human deubiquitinase Poh1 is essential for cell viability , 2007, Molecular Cancer Therapeutics.

[30]  B. Neel,et al.  Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors* , 2003, Journal of Biological Chemistry.

[31]  Austin G Smith,et al.  Signalling, cell cycle and pluripotency in embryonic stem cells. , 2002, Trends in cell biology.

[32]  F. Hamdan,et al.  A Schistosoma mansoni Pad1 homologue stabilizes c-Jun. , 2001, Molecular and biochemical parasitology.

[33]  J. Llovet,et al.  Medical therapies for hepatocellular carcinoma: a critical view of the evidence , 2013, Nature Reviews Gastroenterology &Hepatology.