Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1‐q32

Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at 0 = 0 and α of 0.5 and nearby markers also produced positive values.