论文信息 - Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.

Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.

The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.

[1] G. Dickneite,et al. Cefodizime, an aminothiazolyl cephalosporin. IV. Influence on the immune system. , 1984, The Journal of antibiotics.

[2] R. Jones,et al. In vitro antimicrobial activity evaluation of cefodizime (HR221), a new semisynthetic cephalosporin , 1981, Antimicrobial Agents and Chemotherapy.

[3] P. Angehrn,et al. Ro 13-9904/001, a novel potent and long-acting parenteral cephalosporin. , 1980, The Journal of antibiotics.

[4] M. Nishida,et al. Comparison of antibacterial activity of a new cephalosporin, ceftizoxime (FK 749) with other cephalosporin antibiotics. , 1979, The Journal of antibiotics.

[5] R. Heymes,et al. Cephalosporines a chaines amino-2 thiazolyl-4 acetyles: Influence de la presence et de la configuration d'un groupe oxyimino sur l'activite antibacterienne , 1978 .

[6] A. Morimoto,et al. New cephalosporin derivatives with high antibacterial activities. , 1977, Chemical & pharmaceutical bulletin.