Cardiovascular Care in the Era of Machine Learning enabled Personalized Medicine

Precision medicine in cardiology, a concept still in its infancy, has already seen much useful research work done. Cardiovascular disease is the number one cause of deaths worldwide, representing almost 31% of all global fatalities, many of these being premature, preventable deaths. We collected all the relevant data of recent times in the field of personalized cardiovascular medicine to give an abstract overview of the work done in the past concerning individual fields of cardiology where most of the research was done. We also focused on the fact of whether it involved diagnostic or therapeutic strategies with an insight into its impact on clinical decision support systems. We have reviewed these articles by forming several research questions, and the answers to those questions, when sought and discussed, provide a glimpse of all the pertinent past data in personalized cardiovascular care. It also gives an insight into those areas which are well on course to catch the eye of future researchers. We have concluded with some suggestions for future work, which includes involvement of deep learning techniques through machine learning to make clinical decision support systems, which in turn can help modern-day clinicians to make this world much healthier than before.

[1]  Sanjiv J Shah,et al.  Precision Medicine for Heart Failure with Preserved Ejection Fraction: An Overview , 2017, Journal of Cardiovascular Translational Research.

[2]  Different races, different atherosclerosis? Future suggestions for precision cardiovascular medicine. , 2018, International journal of cardiology.

[3]  Ralph Weissleder,et al.  Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research , 2016, JACC. Basic to translational science.

[4]  G. Grassi,et al.  Personalized medicine—a modern approach for the diagnosis and management of hypertension , 2017, Clinical science.

[5]  Kipp W. Johnson,et al.  Deep learning for cardiovascular medicine: a practical primer. , 2019, European heart journal.

[6]  J. Moslehi,et al.  Cardiac Toxicities in the Era of Precision Medicine: Underlying Risk Factors, Targeted Therapies, and Cardiac Biomarkers. , 2018, American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting.

[7]  T. Omland Cardiac troponins: a tool for a personalized medicine strategy in stable coronary artery disease? , 2014, Journal of the American College of Cardiology.

[8]  G. Ginsburg,et al.  Prospects for personalized cardiovascular medicine: the impact of genomics. , 2005, Journal of the American College of Cardiology.

[9]  M. Budoff,et al.  Clinical Utility of a Precision Medicine Test Evaluating Outpatients with Suspected Obstructive Coronary Artery Disease. , 2017, The American journal of medicine.

[10]  I. Kullo,et al.  Precision Cardiovascular Medicine: State of Genetic Testing , 2017, Mayo Clinic proceedings.

[11]  T. Vondriska,et al.  Operationalizing Precision Cardiovascular Medicine: Three Innovations. , 2016, Circulation research.

[12]  Padmavathi Kora,et al.  Detection of Cardiac arrhythmia using fuzzy logic , 2019, Informatics in Medicine Unlocked.

[13]  A. Pasipoularides Implementing genome-driven personalized cardiology in clinical practice. , 2018, Journal of molecular and cellular cardiology.

[14]  G. Shui,et al.  Metabolomics through the lens of precision cardiovascular medicine. , 2017, Journal of genetics and genomics = Yi chuan xue bao.

[15]  M. Joyner Precision Medicine, Cardiovascular Disease and Hunting Elephants. , 2016, Progress in cardiovascular diseases.

[16]  C. Spickett,et al.  Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. , 2018, Journal of proteomics.

[17]  Joseph Loscalzo,et al.  Opportunities for the Cardiovascular Community in the Precision Medicine Initiative , 2016, Circulation.

[18]  Robert M Wachter,et al.  Promoting Trust Between Patients and Physicians in the Era of Artificial Intelligence. , 2019, JAMA.

[19]  P. Ping,et al.  Proteomics Research in Cardiovascular Medicine and Biomarker Discovery. , 2016, Journal of the American College of Cardiology.

[20]  C. Spickett,et al.  Reprint of: Proteomics in cardiovascular diseases: Unveiling sex and gender differences in the era of precision medicine. , 2018, Journal of proteomics.

[21]  L. Berglund,et al.  Non-HDL-C levels and residual cardiovascular risk: Do population-specific precision approaches offer advantages? , 2018, Atherosclerosis.

[22]  Andre Esteva,et al.  A guide to deep learning in healthcare , 2019, Nature Medicine.

[23]  J. Schussler,et al.  Advanced technology in interventional cardiology: A roadmap for the future of precision coronary interventions. , 2016, Trends in cardiovascular medicine.

[24]  R. Arena,et al.  Applying Precision Medicine to Healthy Living for the Prevention and Treatment of Cardiovascular Disease. , 2018, Current problems in cardiology.