Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat
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[1] P. Kingham,et al. Microglial Apoptosis Induced by Chromogranin A Is Mediated by Mitochondrial Depolarisation and the Permeability Transition but Not by Cytochrome c Release , 2000, Journal of neurochemistry.
[2] A. Asai,et al. High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis* , 1999, The Journal of Biological Chemistry.
[3] M. Martone,et al. Survival- and Death-Promoting Events after Transient Cerebral Ischemia: Phosphorylation of Akt, Release of Cytochrome C, and Activation of Caspase-Like Proteases , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[4] B. Siesjö,et al. Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia , 1999, Brain Research.
[5] E. Kandel,et al. Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria , 1999, Molecular and Cellular Biology.
[6] T. Wieloch,et al. Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[7] J C Reed,et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. , 1999, Science.
[8] Ping-An Li,et al. Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat , 1998, Brain Research.
[9] G. Fiskum,et al. Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition , 1998, FEBS letters.
[10] Jean-Claude Martinou,et al. Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions , 1998, The Journal of cell biology.
[11] J. Woodgett,et al. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. , 1998, The Biochemical journal.
[12] T. Wieloch,et al. Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death , 1998, The Journal of Neuroscience.
[13] M. Moskowitz,et al. Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.
[14] G. Kroemer,et al. The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins , 1998, The Journal of experimental medicine.
[15] J. Downward. Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.
[16] N. Hay,et al. Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line , 1998, Molecular and Cellular Biology.
[17] S. Kuroda,et al. The Immunosuppressant Drug FK506 Ameliorates Secondary Mitochondrial Dysfunction Following Transient Focal Cerebral Ischemia in the Rat , 1997, Neurobiology of Disease.
[18] L. Peso,et al. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.
[19] S. R. Datta,et al. Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.
[20] S. Butcher,et al. Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism , 1997, The Journal of Neuroscience.
[21] T. Tsuruo,et al. Interaction of cyclosporin derivatives with the ATPase activity of human P‐glycoprotein , 1997, British journal of pharmacology.
[22] F. Shibasaki,et al. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 , 1997, Nature.
[23] B. Siesjö,et al. Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia , 1997, Brain Research.
[24] S. Snyder,et al. Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A , 1997, Nature Medicine.
[25] S. Orrenius,et al. Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death , 1996, FEBS letters.
[26] S. Kuroda,et al. Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia , 1996 .
[27] D. Choi,et al. Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis? , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[28] O. Lindvall,et al. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. , 1995, Acta physiologica Scandinavica.
[29] B. Siesjö,et al. N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[30] I. Tamai,et al. In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. , 1994, Biochemical pharmacology.
[31] S. Butcher,et al. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia , 1994, Nature.
[32] T. Tsuruo,et al. Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. , 1994, Biochimica et biophysica acta.
[33] I. Tamai,et al. Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. , 1990, The Journal of biological chemistry.
[34] W. Pardridge,et al. Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins , 1990, Journal of neurochemistry.
[35] W. Pardridge,et al. Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. , 1990, The Journal of pharmacology and experimental therapeutics.
[36] L. Pitts,et al. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. , 1986, Stroke.