Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat

[1]  P. Kingham,et al.  Microglial Apoptosis Induced by Chromogranin A Is Mediated by Mitochondrial Depolarisation and the Permeability Transition but Not by Cytochrome c Release , 2000, Journal of neurochemistry.

[2]  A. Asai,et al.  High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis* , 1999, The Journal of Biological Chemistry.

[3]  M. Martone,et al.  Survival- and Death-Promoting Events after Transient Cerebral Ischemia: Phosphorylation of Akt, Release of Cytochrome C, and Activation of Caspase-Like Proteases , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  B. Siesjö,et al.  Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia , 1999, Brain Research.

[5]  E. Kandel,et al.  Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria , 1999, Molecular and Cellular Biology.

[6]  T. Wieloch,et al.  Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  J C Reed,et al.  Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. , 1999, Science.

[8]  Ping-An Li,et al.  Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat , 1998, Brain Research.

[9]  G. Fiskum,et al.  Cytochrome c release from brain mitochondria is independent of the mitochondrial permeability transition , 1998, FEBS letters.

[10]  Jean-Claude Martinou,et al.  Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions , 1998, The Journal of cell biology.

[11]  J. Woodgett,et al.  Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. , 1998, The Biochemical journal.

[12]  T. Wieloch,et al.  Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death , 1998, The Journal of Neuroscience.

[13]  M. Moskowitz,et al.  Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.

[14]  G. Kroemer,et al.  The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins , 1998, The Journal of experimental medicine.

[15]  J. Downward Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.

[16]  N. Hay,et al.  Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line , 1998, Molecular and Cellular Biology.

[17]  S. Kuroda,et al.  The Immunosuppressant Drug FK506 Ameliorates Secondary Mitochondrial Dysfunction Following Transient Focal Cerebral Ischemia in the Rat , 1997, Neurobiology of Disease.

[18]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[19]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[20]  S. Butcher,et al.  Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism , 1997, The Journal of Neuroscience.

[21]  T. Tsuruo,et al.  Interaction of cyclosporin derivatives with the ATPase activity of human P‐glycoprotein , 1997, British journal of pharmacology.

[22]  F. Shibasaki,et al.  Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 , 1997, Nature.

[23]  B. Siesjö,et al.  Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia , 1997, Brain Research.

[24]  S. Snyder,et al.  Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, rapamycin and cyclosporin A , 1997, Nature Medicine.

[25]  S. Orrenius,et al.  Calcineurin and mitochondrial function in glutamate‐induced neuronal cell death , 1996, FEBS letters.

[26]  S. Kuroda,et al.  Postischemic administration of FK506 reduces infarct volume following transient focal brain ischemia , 1996 .

[27]  D. Choi,et al.  Very Delayed Infarction after Mild Focal Cerebral Ischemia: A Role for Apoptosis? , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[28]  O. Lindvall,et al.  Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. , 1995, Acta physiologica Scandinavica.

[29]  B. Siesjö,et al.  N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  I. Tamai,et al.  In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. , 1994, Biochemical pharmacology.

[31]  S. Butcher,et al.  Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia , 1994, Nature.

[32]  T. Tsuruo,et al.  Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. , 1994, Biochimica et biophysica acta.

[33]  I. Tamai,et al.  Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells. , 1990, The Journal of biological chemistry.

[34]  W. Pardridge,et al.  Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins , 1990, Journal of neurochemistry.

[35]  W. Pardridge,et al.  Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. , 1990, The Journal of pharmacology and experimental therapeutics.

[36]  L. Pitts,et al.  Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. , 1986, Stroke.