guide) for interventional CT-guided procedures. Purpose: Evaluation of the accuracy of a new electromagnetic target system for interventional CT-guided procedures with virtual navigation in a previously acquired helical CT. Material and Methods: The new target system CT-Guide 1010 (Ultraguide, Tirat Hacarmel, Israel) for CT-guided interventions was adapted to the video signal of the Somatom Plus 4 and Volume Zoom (Siemens, Erlangen, Germany). A helical CT-dataset including skin-based sensor cubes was transferred to the integrated navigation system inside the scanner room. 50 image-guided interventions and biopsies were performed outside the gantry using virtual navigation to reach the lesion. The accuracy of the procedures was evaluated using documentation of the needle tip with CT-fluoroscopy, results of histology, and follow-up. Results: The deviation between planned and documented needle tip was 2.2±2.1 mm in 50 procedures. Time between the end of planning-CT and needle positioning using the system was 13 minutes. There were no complications due to the use of the system. Conclusion: The CT-Guide allows for virtual real-time navigation with high accuracy. Advantages are the free needle angulation without gantry tilt, use of optimal CT perfusion phase for virtual navigation, and reduction of radiation exposure to the patient and interventionalist.