Immunoglobulin kappa light chain gene rearrangement is impaired in mice deficient for DNA polymerase mu.

[1]  F. Alt,et al.  Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[2]  David Baltimore,et al.  Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells , 1984, Nature.

[3]  Naomi Rosenberg,et al.  The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination , 1988, Cell.

[4]  D. Baltimore,et al.  Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription , 1989, Cell.

[5]  D. Schatz,et al.  RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. , 1990, Science.

[6]  E. Kabat,et al.  Sequences of proteins of immunological interest , 1991 .

[7]  R. Hardy,et al.  The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver , 1993, The Journal of experimental medicine.

[8]  F. Alt,et al.  Impairment of V(D)J recombination in double-strand break repair mutants. , 1993, Science.

[9]  D. Ramsden,et al.  Formation and resolution of double-strand break intermediates in V(D)J rearrangement. , 1995, Genes & development.

[10]  A. Lesk,et al.  The structural repertoire of the human V kappa domain. , 1995, The EMBO journal.

[11]  F. Alt,et al.  Growth retardation and leaky SCID phenotype of Ku70-deficient mice. , 1997, Immunity.

[12]  M. Gellert.  Recent advances in understanding V(D)J recombination. , 1997, Advances in immunology.

[13]  Peer Bork,et al.  A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  B. Ponder,et al.  Involvement of Brca2 in DNA repair. , 1998, Molecular cell.

[15]  F. Alt,et al.  A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. , 1998, Immunity.

[16]  F. Delbos,et al.  Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process. , 1998, Immunity.

[17]  S. Pillai,et al.  The chosen few? Positive selection and the generation of naive B lymphocytes. , 1999, Immunity.

[18]  M. Lieber.  The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes , 1999, Genes to cells : devoted to molecular & cellular mechanisms.

[19]  L. Bentolila,et al.  Extensive junctional diversity in Ig light chain genes from early B cell progenitors of mu MT mice. , 1999, Journal of immunology.

[20]  K. Mahajan,et al.  Association of terminal deoxynucleotidyl transferase with Ku. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[21]  S. Schurmans,et al.  A targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line. , 1999 .

[22]  Roger Woodgate,et al.  Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis , 2000, Nature.

[23]  T. Kirchhoff,et al.  DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. , 2000, The EMBO journal.

[24]  F. Delbos,et al.  Two novel human and mouse DNA polymerases of the polX family. , 2000, Nucleic acids research.

[25]  Yanbin Zhang,et al.  Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase μ , 2001, Molecular and Cellular Biology.

[26]  J. Kearney,et al.  Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase. , 2001, Nucleic acids research.

[27]  M. García-Díaz,et al.  DNA polymerase mu, a candidate hypermutase? , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[28]  A. Fischer,et al.  Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency , 2001, Cell.

[29]  F. Delbos,et al.  Transcription, β–like DNA polymerases and hypermutation , 2001 .

[30]  D. Schatz,et al.  Factors and forces controlling V(D)J recombination. , 2001, Advances in immunology.

[31]  J. Cabaniols,et al.  Most α/β T Cell Receptor Diversity Is Due to Terminal Deoxynucleotidyl Transferase , 2001, The Journal of experimental medicine.

[32]  Yunmei Ma,et al.  Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination , 2002, Cell.

[33]  Yanbin Zhang,et al.  Lesion Bypass Activities of Human DNA Polymerase μ* , 2002, The Journal of Biological Chemistry.

[34]  F. Alt,et al.  The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.

[35]  J. Kearney,et al.  Distinct and opposite diversifying activities of terminal transferase splice variants , 2002, Nature Immunology.

[36]  B. Bertocci,et al.  Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation1 , 2002, The Journal of Immunology.

[37]  L. Blanco,et al.  Human DNA polymerase mu (Pol mu) exhibits an unusual replication slippage ability at AAF lesion. , 2002, Nucleic acids research.

[38]  D. Ramsden,et al.  Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair , 2002, Molecular and Cellular Biology.

[39]  D. Ramsden,et al.  Translesion synthesis past platinum DNA adducts by human DNA polymerase mu. , 2003, Biochemistry.