Proton magnetic resonance spectroscopy with metabolite nulling reveals regional differences of macromolecules in normal human brain

To quantify the macromolecular content in different anatomic brain regions and to evaluate an age dependency of the macromolecular concentrations.

[1]  Jullie W Pan,et al.  Evaluation of multiple sclerosis by 1H spectroscopic imaging at 4.1 T , 1996, Magnetic resonance in medicine.

[2]  D. Saunders,et al.  Discrimination of Metabolite from Lipid and Macromolecule Resonances in Cerebral Infarction in Humans Using Short Echo Proton Spectroscopy , 1997, Journal of magnetic resonance imaging : JMRI.

[3]  Roland Kreis,et al.  Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy , 1993, Magnetic resonance in medicine.

[4]  U. Klose,et al.  Reliable detection of macromolecules in single‐volume 1H NMR spectra of the human brain , 2001, Magnetic resonance in medicine.

[5]  P. Kaldis,et al.  'Hot spots' of creatine kinase localization in brain: cerebellum, hippocampus and choroid plexus. , 1996, Developmental neuroscience.

[6]  Takashi Ogino,et al.  Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain , 1993, Magnetic resonance in medicine.

[7]  U Klose,et al.  Proton MR spectroscopy with metabolite-nulling reveals elevated macromolecules in acute multiple sclerosis. , 2001, Brain : a journal of neurology.

[8]  G Helms,et al.  Analysis of 1.5 Tesla proton MR spectra of human brain using LCModel and an imported basis set. , 1999, Magnetic resonance imaging.

[9]  J. Frahm,et al.  Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS , 1998, Magnetic resonance in medicine.

[10]  C Boesch,et al.  Characterization of the macromolecule baseline in localized 1H‐MR spectra of human brain , 2001, Magnetic resonance in medicine.

[11]  R Gruetter,et al.  Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time (1)H NMR spectra of the rat brain. , 1999, Journal of magnetic resonance.

[12]  B D Ross,et al.  Absolute Quantitation of Water and Metabolites in the Human Brain. II. Metabolite Concentrations , 1993 .

[13]  K. Behar,et al.  Analysis of macromolecule resonances in 1H NMR spectra of human brain , 1994, Magnetic resonance in medicine.

[14]  D J Drost,et al.  Factors affecting the quantification of short echo in‐vivo 1H MR spectra: prior knowledge, peak elimination, and filtering , 1999, NMR in biomedicine.

[15]  P. Barker,et al.  Metabolic heterogeneity at the level of the anterior and posterior commissures , 2000, Magnetic resonance in medicine.

[16]  N. Schuff,et al.  Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. , 2000, Magnetic resonance imaging.

[17]  J. Hennig,et al.  Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy , 1992, NMR in biomedicine.

[18]  K. Behar,et al.  Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain , 1996, Magnetic resonance in medicine.

[19]  S. Provencher Estimation of metabolite concentrations from localized in vivo proton NMR spectra , 1993, Magnetic resonance in medicine.

[20]  Shi-Jiang Li,et al.  Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy , 1998, Magnetic resonance in medicine.

[21]  J. Frahm,et al.  Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. , 1993, Radiology.