A radio-frequency system for in vivo pilot experiments aimed at the studies on biological effects of electromagnetic fields

An exposure system consisting of two long transversal electromagnetic (TEM) cells, operating at a frequency of 900 MHz, is presented and discussed. The set-up allows simultaneous exposure of a significant number of animals (up to 12 mice per cell) in a blind way to a uniform plane wave at a frequency of 900 MHz, for investigating possible biological effects of exposure to electromagnetic fields produced by wireless communication systems. A heating/refrigerating system has also been designed for maintaining comfortable environmental conditions within the TEM cells during experiments. An accurate dosimetric study has been performed both numerically and by means of direct measurements on phantoms and living mice. The results have shown that good homogeneity of exposure and adequate power efficiency, in terms of whole-body specific absorption rate (SAR) per 1 W of input power, are achievable for the biological target.

[1]  P. Heikkinen,et al.  Effects of Mobile Phone Radiation on X-Ray-Induced Tumorigenesis in Mice , 2001, Radiation research.

[2]  C. Chan,et al.  Boundary element method analysis for the bioheat transfer equation. , 1992, Journal of biomechanical engineering.

[3]  M Taki,et al.  Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay. , 1998, Carcinogenesis.

[4]  J J Lagendijk,et al.  The significance of accurate dielectric tissue data for hyperthermia treatment planning. , 2001, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[5]  A Basten,et al.  Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. , 1997, Radiation research.

[6]  P. Heikkinen,et al.  Effects of mobile phone radiation on UV-induced skin tumourigenesis in ornithine decarboxylase transgenic and non-transgenic mice , 2003, International journal of radiation biology.

[7]  N Kuster,et al.  Recommended minimal requirements and development guidelines for exposure setups of bio-experiments addressing the health risk concern of wireless communications. , 2000, Bioelectromagnetics.

[8]  Renato Cicchetti,et al.  An efficient RF exposure system with precise whole-body average SAR determination for in vivo animal studies at 900 MHz , 2000 .

[9]  Space efficient system for small animal, whole body microwave exposure at 1.6 GHz. , 2002, Bioelectromagnetics.

[10]  R. Pinto,et al.  Effects of In Vivo Exposure to GSM-Modulated 900 MHz Radiation on Mouse Peripheral Lymphocytes , 2003, Radiation research.

[11]  M. Repacholi Low-level exposure to radiofrequency electromagnetic fields: health effects and research needs. , 1998, Bioelectromagnetics.

[12]  Myron L. Crawford,et al.  Generation of Standard EM Fields Using TEM Transmission Cells , 1974 .

[13]  Volkert Hansen,et al.  RF exposure of biological systems in radial waveguides , 1999 .

[14]  Compact shielded exposure system for the simultaneous long-term UHF irradiation of forty small mammals. II. Dosimetry. , 1999, Bioelectromagnetics.

[15]  W F Pickard,et al.  A compact shielded exposure system for the simultaneous long-term UHF irradiation of forty small mammals: I. Electromagnetic and environmental design. , 1998, Bioelectromagnetics.

[16]  James C. Lin,et al.  Radio frequency electromagnetic exposure: tutorial review on experimental dosimetry. , 1996, Bioelectromagnetics.

[17]  S. Weinbaum,et al.  A new simplified bioheat equation for the effect of blood flow on local average tissue temperature. , 1985, Journal of biomechanical engineering.

[18]  W. R. Adey,et al.  Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves. , 1999, Radiation research.

[19]  Masao Taki,et al.  The 1.5 GHz Electromagnetic Near‐field Used for Cellular Phones Does Not Promote Rat Liver Carcinogenesis in a Medium‐term Liver Bioassay , 1998, Japanese journal of cancer research : Gann.

[20]  Bowman Hf Heat transfer mechanisms and thermal dosimetry. , 1982 .

[21]  Val Gebski,et al.  Long-Term Exposure of Eμ-Pim1 Transgenic Mice to 898.4 MHz Microwaves does not Increase Lymphoma Incidence , 2002, Radiation research.

[22]  Simulation of the effect of inhomogeneities in TEM transmission cells using the FDTD-method , 1992 .