Intrathecal Morphine Infusion for Chronic Non‐Malignant Pain: A Multiple Center Retrospective Survey

Intrathecal morphine (ITM) is commonly used for the treatment of cancer pain. There is reluctance for its use in France to treat chronic noncancer pain. In order to appreciate its popularity, efficacy, dose escalation with time, and long‐term tolerance, we carried out a retrospective study in the neurosurgery departments of university teaching hospitals in France involved in intrathecal drug therapy.

[1]  G. Racz,et al.  Predictive Value of Intrathecal Narcotic Trials for Long‐Term Therapy with Implantable Drug Administration Systems in Chronic Non‐Cancer Pain Patients , 2002, Pain practice : the official journal of World Institute of Pain.

[2]  J. Bartleson,et al.  Evidence for and against the use of opioid analgesics for chronic nonmalignant low back pain: a review. , 2002, Pain medicine.

[3]  M. L. Gay.  Spinal Morphine in Nonmalignant Chronic Pain: A Retrospective Study in 39 Patients , 2002, Neuromodulation : journal of the International Neuromodulation Society.

[4]  L. J. Roberts,et al.  Outcome of intrathecal opioids in chronic non‐cancer pain , 2001, European journal of pain.

[5]  M. Kelly,et al.  Continuous intrathecal morphine treatment for chronic pain of nonmalignant etiology: long-term benefits and efficacy. , 2001, Surgical neurology.

[6]  L. J. Roberts,et al.  Hypogonadism in patients treated with intrathecal morphine. , 2000, The Clinical journal of pain.

[7]  J. van Buyten,et al.  Endocrine consequences of long-term intrathecal administration of opioids. , 2000, The Journal of clinical endocrinology and metabolism.

[8]  A. Dickenson,et al.  The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain , 1999, Pain.

[9]  K J Burchiel,et al.  A prospective study of long-term intrathecal morphine in the management of chronic nonmalignant pain. , 1999, Neurosurgery.

[10]  B. Veering,et al.  Intrathecal Drug Spread: Is It Controllable? , 1998, Regional Anesthesia & Pain Medicine.

[11]  R. Portenoy,et al.  Clinical realities and economic considerations: special therapeutic issues in intrathecal therapy--tolerance and addiction. , 1997, Journal of pain and symptom management.

[12]  W. Winkelmüller,et al.  Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology. , 1996, Journal of neurosurgery.

[13]  E. Spatz,et al.  Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity. , 1996, Journal of neurosurgery.

[14]  D. Doleys,et al.  Intrathecal Infusion Systems for Treatment of Chronic Low Back and Leg Pain of Noncancer Origin , 1996, Southern medical journal.

[15]  R. Penn,et al.  Intraspinal morphine for chronic pain: a retrospective, multicenter study. , 1996, Journal of pain and symptom management.

[16]  R. Penn,et al.  Amenorrhea associated with intraspinal morphine. , 1995, Journal of Pain and Symptom Management.

[17]  R. Kanoff.  Intraspinal delivery of opiates by an implantable, programmable pump in patients with chronic, intractable pain of nonmalignant origin , 1994, The Journal of the American Osteopathic Association.

[18]  R. Penn,et al.  Altered sexual function and decreased testosterone in patients receiving intraspinal opioids. , 1994, Journal of pain and symptom management.

[19]  A. Jadad,et al.  Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia , 1992, The Lancet.

[20]  N. Waterman,et al.  Control of cancer pain by epidural infusion of morphine. , 1992, Surgery.

[21]  A. Caraceni,et al.  Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine , 1991, Pain.

[22]  R. Portenoy,et al.  The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions , 1990, Pain.

[23]  Russell K. Portenoy,et al.  Chronic use of opioid analgesics in non-malignant pain: Report of 38 cases , 1986, Pain.

[24]  T. Yaksh,et al.  High Doses of Spinal Morphine Produce a Nonopiate Receptormediated Hyperesthesia: Clinical and Theoretic Implications , 1986, Anesthesiology.

[25]  A. Auld,et al.  Intraspinal Narcotic Analgesia in the Treatment of Chronic Pain , 1985, Spine.

[26]  John E. Thomas,et al.  Pain relief by intrathecally applied morphine in man. , 1979, Anesthesiology.

[27]  F. Magora,et al.  EPIDURAL MORPHINE IN TREATMENT OF PAIN , 1979, The Lancet.

[28]  J. Salomon,et al.  Immunostimulants in primary hepatomas , 1975, The Lancet.