Printed skin-conformal bioelectronics for wireless continuous stress monitoring and management

Stress in daily life has become a significant issue due to health risks. Because many sources of stress are unavoidable, management of stress is critical. Recent wearable devices, detecting physiological signals such as electrodermal activity, have been developed for quantitative and practical stress management assessment. However, they rely on a rigid and bulky system that is uncomfortable to wear during daily activities and has significant motion artifact issues. Here, we introduce a wireless skin-conformal bioelectronic system that evaluates daily stress management. Ultrathin, stretchable circuit system incorporated with a silicone elastomer enables a soft lamination on the skin, providing portable, continuous monitoring of stress. Printed, biocompatible nanomembrane electrodes on a breathable silicone tape provide long-term wearability and skin compatibility, enabling seamless monitoring of galvanic skin response at home with daily activities. Demonstration of stress management practice with human subjects shows the effectiveness of stress alleviation with a promising, non-invasive, and portable wearable system.

[1]  M. Kalia,et al.  Assessing the economic impact of stress--the modern day hidden epidemic. , 2002, Metabolism: clinical and experimental.

[2]  I. Painter,et al.  Protocol: a multi-level intervention program to reduce stress in 9-1-1 telecommunicators , 2018, BMC Public Health.

[3]  F. Smit,et al.  A health economic outcome evaluation of an internet-based mobile-supported stress management intervention for employees. , 2017, Scandinavian journal of work, environment & health.

[4]  Torbjörn Akerstedt,et al.  Psychosocial stress and impaired sleep. , 2006, Scandinavian journal of work, environment & health.

[5]  Heleen Riper,et al.  Web-Based and Mobile Stress Management Intervention for Employees: A Randomized Controlled Trial , 2016, Journal of medical Internet research.

[6]  Shinjae Kwon,et al.  All-printed nanomembrane wireless bioelectronics using a biocompatible solderable graphene for multimodal human-machine interfaces , 2020, Nature Communications.

[7]  T. Probst Conducting effective stress intervention research: strategies for achieving an elusive goal. , 2013, Stress and health : journal of the International Society for the Investigation of Stress.

[8]  Shinjae Kwon,et al.  Wireless, continuous monitoring of daily stress and management practice via soft bioelectronics. , 2020, Biosensors & bioelectronics.

[9]  B. McEwen Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. , 2008, European journal of pharmacology.

[10]  Stefan Winkler,et al.  ASCERTAIN: Emotion and Personality Recognition Using Commercial Sensors , 2018, IEEE Transactions on Affective Computing.

[11]  Joseph G. Allen,et al.  Effects of Biophilic Interventions in Office on Stress Reaction and Cognitive Function: A Randomized Crossover Study in Virtual Reality. , 2019, Indoor air.

[12]  Adrian Basarab,et al.  Towards an automatic early stress recognition system for office environments based on multimodal measurements: A review , 2016, J. Biomed. Informatics.

[13]  John-John Cabibihan,et al.  Physiological Responses to Affective Tele-Touch during Induced Emotional Stimuli , 2017, IEEE Transactions on Affective Computing.

[14]  Shinjae Kwon,et al.  Fully Integrated, Stretchable, Wireless Skin‐Conformal Bioelectronics for Continuous Stress Monitoring in Daily Life , 2020, Advanced science.

[15]  Tamás D. Gedeon,et al.  Objective measures, sensors and computational techniques for stress recognition and classification: A survey , 2012, Comput. Methods Programs Biomed..

[16]  Cem Ersoy,et al.  Stress detection in daily life scenarios using smart phones and wearable sensors: A survey , 2019, J. Biomed. Informatics.

[17]  Woon-Hong Yeo,et al.  Soft Wireless Bioelectronics and Differential Electrodermal Activity for Home Sleep Monitoring , 2021, Sensors.

[18]  Chris Van Hoof,et al.  A Data Driven Empirical Iterative Algorithm for GSR Signal Pre-Processing , 2018, 2018 26th European Signal Processing Conference (EUSIPCO).

[19]  S. Olbrich,et al.  Exposure and response prevention therapy augmented with naltrexone in kleptomania: a controlled case study using galvanic skin response for monitoring , 2019, Behavioural and Cognitive Psychotherapy.

[20]  Jae‐Woong Jeong,et al.  Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment , 2019, Advanced materials.

[21]  Antonio Artés-Rodríguez,et al.  Feature Extraction of Galvanic Skin Responses by Nonnegative Sparse Deconvolution , 2018, IEEE Journal of Biomedical and Health Informatics.

[22]  Franz Gravenhorst,et al.  Towards long term monitoring of electrodermal activity in daily life , 2013, Personal and Ubiquitous Computing.